tullio giraldi (29 Ergebnisse)

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,650grams, ISBN:0306436671.

Zustand: New. In.

Zustand: new.

Zustand: NEW.

Zustand: New. In.

Zustand: New. In English.

Taschenbuch. Zustand: Neu. Triazenes | Chemical, Biological, and Clinical Aspects | Tullio Giraldi (u. a.) | Taschenbuch | viii | Englisch | 2012 | Springer | EAN 9781461367109 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - More than 25 years have elapsed since the development of the seminal idea which led to the synthesis of dimethyl triazenes as antitumor agents. The original suggestion of Shealy et ale was to use 4-imidazone-carboxarnide as the carrier of a nitro gen-containing cytotoxic function. 5-diazoimidazole-4-carbox amide (diazo-IC) was synthesized and tested in mice as a potential inhibitor of de novo purine biosynthesis. Its lack of antitumor action was attributed to its polarity and to the resulting poor uptake of this hydrophilic chemical. Diazo-IC was then coupled with dimethylamine, yielding 5, (3,3-dimethyl l-triazeno)imidazole-4-carboxamide) (DTIC) with the intention of obtaining a less polar and more lipophil~c prod rug which might release diazo-IC intracellularly. Preliminary tests showed that DTIC had good antiumor activity in experimental systems. Further tests demonstrated a broad spectrum of action against rodent tumors, and clinical trials indicated activity against human malignancies. Subsequent clinical use of DTIC has demonstrated its usefulness against malignant melanoma, for which it is currently the drug of choice, and its effective ness in combination chemotherapy in the treatment of other human cancers. Because of its antitumor activity the mechan ism of action of DTIC has been investigated in some detail. The original rationale for its development, that is, the hydrolysis in vivo to diazo-IC, has been shown not to be in volved in th-e-mechansims of action. DTIC requires metabolic acti vation before it exerts its biological effects.

Zustand: New. In.

Hardcover. Zustand: Brand New. 202 pages. 8.50x6.00x0.75 inches. In Stock.

Hardcover. Zustand: Brand New. 236 pages. 9.61x6.69x0.56 inches. In Stock.

Zustand: New. 2017. Hardcover. . . . . . Books ship from the US and Ireland.

Gebunden. Zustand: New. KlappentextA class of antitumor agents is discussed in 16 papers, which include explorations of the synthesis, chemical properties, biotransformation, and pharmacokinetics in animals and humans, and studies of analogous agents and substa.

Taschenbuch. Zustand: Neu. Unhappiness, Sadness and 'Depression' | Antidepressants and the Mental Disorder Epidemic | Tullio Giraldi | Taschenbuch | xiv | Englisch | 2018 | Springer | EAN 9783319862187 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book examines existing treatments, legislation and research methodology of depression and exposes their limitations, championing psycho-social support as an alternative. Depression, affecting 350 million people according to the World Health Organisation, is almost invariably diagnosed by the criteria of the American Psychiatric Association - a definition which encompasses those with normal emotional responses to stressful life events. Tullio Giraldi discusses recent developments in popular and academic dialogue related to the use of antidepressants and recent increases in depression diagnosis and laments the rise in prescribing antidepressants despite their links to suicide and unfulfilled promises of efficacy and safety. He argues that psychotherapy is a cost effective treatment devoid of drugs' adverse effects. This work presents psycho-social support as an alternative to antidepressants, particularly for less severe cases, and as a more effective strategy for coping with the emotional challenges of today's global reality. Patients, students of medicine and psychology, and professionals of mental health will find this work valuable.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book examines existing treatments, legislation and research methodology of depression and exposes their limitations, championing psycho-social support as an alternative. Depression, affecting 350 million people according to the World Health Organisation, is almost invariably diagnosed by the criteria of the American Psychiatric Association - a definition which encompasses those with normal emotional responses to stressful life events. Tullio Giraldi discusses recent developments in popular and academic dialogue related to the use of antidepressants and recent increases in depression diagnosis and laments the rise in prescribing antidepressants despite their links to suicide and unfulfilled promises of efficacy and safety. He argues that psychotherapy is a cost effective treatment devoid of drugs' adverse effects. This work presents psycho-social support as an alternative to antidepressants, particularly for less severe cases, and as a more effective strategy for coping with the emotional challenges of today's global reality. Patients, students of medicine and psychology, and professionals of mental health will find this work valuable.

Paperback. Zustand: Brand New. reprint edition. 216 pages. 8.27x5.83x0.49 inches. In Stock.

Hardcover. Zustand: Brand New. 238 pages. 8.75x6.25x0.75 inches. In Stock.

Taschenbuch. Zustand: Neu. Psychotherapy, Mindfulness and Buddhist Meditation | Tullio Giraldi | Taschenbuch | xv | Englisch | 2020 | Springer | EAN 9783030290054 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book critically examines the development of mindfulness, tracing its development from Buddhist meditation to its variety of popular applications today, including the treatment of mental disorders, wellbeing and improvement of performance. The book begins with a chapter on the meaning of mindfulness, then moves on to chart the spread of Buddhism into the western world and examine the development of Mindfulness Based Cognitive Therapy (MBCT). The second half of the book considers some of the growing concerns related to mindfulness such as the loss of the moral and communitarian values of Buddhism, and the psychologicization and medicalization of existential problems into a capitalist society.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book critically examines the development of mindfulness, tracing its development from Buddhist meditation to its variety of popular applications today, including the treatment of mental disorders, wellbeing and improvement of performance. The book begins with a chapter on the meaning of mindfulness, then moves on to chart the spread of Buddhism into the western world and examine the development of Mindfulness Based Cognitive Therapy (MBCT). The second half of the book considers some of the growing concerns related to mindfulness such as the loss of the moral and communitarian values of Buddhism, and the psychologicization and medicalization of existential problems into a capitalist society.

Zustand: New.

Zustand: New.

Taschenbuch. Zustand: Neu. Zen Buddhism and the Reality of Suffering | Tullio Giraldi | Taschenbuch | xiii | Englisch | 2025 | Springer | EAN 9783031692468 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Buch. Zustand: Neu. Neuware - Triazenes: Synthesis and Chemical Properties.- Mechanisms of the Biological Actions of Triazenes.- Triazenes and Triazene N-Oxides: Antitumour Action in Animal Tumour Systems.- Antimestastatic Action of Triazene Derivatives.- Effects of Triazenes on Immune Responses.- Xenogenization of Experimental Tumors by Triazene Derivatives.- The Metabolism of Antineoplastic Triazenes.- Notes on the Metabolism, Pharmacokinetics and Mode of Action of N-Methyl and N-Ethyl-Triazenes in Relation to Their Pharmacological Activity.- Clinical Use of Triazenes.- Clinical Studies with the p-Carboxyl-Dimethyl-Phenyl-Triazene CB10-277.- Triazenes: Therapeutic Considerations and Perspectives.- Antitumor Imidazotetrazines: Prodrugs Targeted to the Major Groove of DNA.- O6-Alkylguanine-DNA-Alkyltransferase Gene Expression and the Cytotoxicity of Triazenes.- N-Methylmelamines, a Unique Class of Anti-Tumour Agents .- Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives.- 'O6-Alkylguanine-DNA-Alkyltransferase: Significance, Methods of Measurement and Some Human Tumor and Normal Tissue Levels' (Contributions of the Workshop).- Summary of Poster-Sessions.- Contributors.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book offers an accessible guide to the role that Zen has played and, alongside Buddhism, might play in both Eastern and Western attempts to alleviate mental suffering. Since its beginnings 2500 years ago, the central belief of Buddhism has been that what we perceive as 'reality' is a mental representation; a religious belief which has since been substantiated by the evidence of neuroscience.The work and progress of clinical medicine, psychiatry and psychology have attempted to alleviate the sufferings of life, but the current approaches to mental health in psychiatry, the neurosciences and cognitivism don't fully address the complexity and mutual inter-relationship of the variety of factors involved in mental suffering, and its non-linear and chaotic aspects. Zen Buddhism, on the other hand, encourages access to reality, and so this book will explore, scientifically, the ways in which it's guiding principles can be deployed to support and enhance Western, clinical solutions to mental strife.

Hardcover. Zustand: Brand New. 196 pages. 8.26x5.82x8.50 inches. In Stock.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Questo libro postula che gli approcci occidentali della psichiatria e del cognitivismo non affrontano la varietà di fattori coinvolti nella sofferenza mentale esistenziale, mostra come le pratiche e i principi Buddhisti potrebbero contribuire al superamento dei limiti meccanicistici della psichiatria e delle terapie cognitivo comportamentali, ed esplora come il Buddhismo abbia svolto un ruolo nei tentativi sia Orientali che Occidentali di alleviare la sofferenza mentale. Offre una guida accessibile al ruolo che lo Zen ha svolto e, insieme al Buddhismo, potrebbe svolgere per alleviare la sofferenza mentale di natura esistenziale. Fin dai suoi inizi, 2500 anni fa, la convinzione centrale del Buddhismo è stata che ciò che percepiamo come 'realtà' ne è una rappresentazione mentale, e questa visione è stata sostanziata dall'evidenza delle moderne neuroscienze. Il lavoro e il progresso della medicina, della psichiatria e della psicologia hanno tentato di alleviare le sofferenze della vita, ma allo stesso tempo gli attuali approcci alla salute mentale in psichiatria, nelle neuroscienze e nel cognitivismo non affrontano pienamente la complessità e l'interrelazione reciproca della varietà di fattori coinvolti nella sofferenza mentale. Il Buddhismo Zen, d'altra parte, incoraggia un accesso diretto alla realtà interna ed esterna non mediato dalle esperienze del sé, e quindi questo libro si sforzerà di esplorerà, rigorosamente, i modi in cui i suoi principi guida possono essere utilizzati per sostenere e migliorare le soluzioni cliniche occidentali alla sofferenza mentale.