springer us springer new york okt 2007 (29 Ergebnisse)

Buch. Zustand: Neu. Neuware -In developing the tools necessary for the study of complex manifolds, this comprehensive, well-organized treatment presents in its opening chapters a detailed survey of recent progress in four areas: geometry (manifolds with vector bundles), algebraic topology, differential geometry, and partial differential equations. Subsequent chapters then develop such topics as Hermitian exterior algebra and the Hodge \*-operator, harmonic theory on compact manifolds, differential operators on a Kahler manifold, the Hodge decomposition theorem on compact Kahler manifolds, the Hodge-Riemann bilinear relations on Kahler manifolds, Griffiths's period mapping, quadratic transformations, and Kodaira's vanishing and embedding theorems.The third edition of this standard reference contains a new appendix by Oscar Garcia-Prada which gives an overview of the developments in the field during the decades since the book appeared.From a review of the 2nd Edition:¿.the new edition ofProfessor Wells' book is timely and welcome.an excellent introduction for any mathematician who suspects that complex manifold techniques may be relevant to his work.¿Nigel Hitchin, Bulletin of the London Mathematical Society¿Its purpose is to present the basics of analysis and geometry on compact complex manifolds, and is already one of the standard sources for this material.¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Buch. Zustand: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Buch. Zustand: Neu. Neuware -Set-valued analysis is an essential tool for the mathematical formulation of many real-life situations, e.g., equilibrium theory in mathematical economics. This work offers the first comprehensive treatment in book form of the fairly new subdiscipline of enlargements of maximal monotone operators, including several important new results in the field. In the last decades, with the development of nonsmooth optimization, effective algorithms have been developed to solve these kinds of problems, such as nonsmooth variational inequalities. Several of these methods, such as bundle methods for variational problems, are fully developed and analyzed in this book.The first chapters provide a self-contained review of the basic notions and fundamental results in set-valued analysis, including set convergence and continuity of set-valued mappings together with many important results in infinite-dimensional convex analysis, leading to the classical fixed point results due to Ekeland, Caristi and Kakutani. Next, an in-depth introduction to monotone operators is developed, emphasizing results related to maximality of subdifferentials and of sums of monotone operators. Building on this foundational material, the second part of the monograph contains new results (all of them established during the last decade) on the concept of enlargements of monotone operators, with applications to variational inequalities, bundle-type methods, augmented Lagrangian methods, and proximal point algorithms.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 312 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book provides a timely revision of the definitive source for quick reference and up-to-date information on the primary health care of women. Containing contributions by leaders in obstetrics-gynecology, primary care and relevant subspecialties, the book presents the latest information from respected authorities. New case studies have been added at the end of each chapter to provide useful information for the busy clinician. New chapters include: Elderly Patients; Cardiovascular Hypertension; The Role of Applied and Genomic Molecular Biology; and Nutrition, Obesity, and Eating Disorders. This book is a must-have reference for the busy clinicianSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 568 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Sequential Dynamical Systems (SDS) are a class of discrete dynamical systems which significantly generalize many aspects of systems such as cellular automata, and provide a framework for studying dynamical processes over graphs.This text is the first to provide a comprehensive introduction to SDS. Driven by numerous examples and thought-provoking problems, the presentation offers good foundational material on finite discrete dynamical systems which leads systematically to an introduction of SDS. Techniques from combinatorics, algebra and graph theory are used to study a broad range of topics, including reversibility, the structure of fixed points and periodic orbits, equivalence, morphisms and reduction. Unlike other books that concentrate on determining the structure of various networks, this book investigates the dynamics over these networks by focusing on how the underlying graph structure influences the properties of the associated dynamical system.This book is aimed at graduate students and researchers in discrete mathematics, dynamical systems theory, theoretical computer science, and systems engineering who are interested in analysis and modeling of network dynamics as well as their computer simulations. Prerequisites include knowledge of calculus and basic discrete mathematics. Some computer experience and familiarity with elementary differential equations and dynamical systems are helpful but not necessary.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 264 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Paolo Ulivi and David Harland provide in Robotic Exploration of the Solar System a detailed history of unmanned missions of exploration of our Solar System. As in their previous book Lunar Exploration, the subject will be treated wherever possible from an engineering and scientific standpoint. Technical descriptions of the spacecraft, of their mission designs and of instrumentations will be provided. Scientific results will be discussed in considerable depth, together with details of mission management. The book will be comprehensive, covering missions and results from the 1950s until the present day, and some of the latest missions and their results will appear in a popular science book for the first time. The authors will also cover many unflown missions, providing an indication of the ideas that proved to be unfulfilled at the time but which may still be proven and useful in the future. The project will deliver three volumes totaling over 1000 pages, providing comprehensive coverage of the topic.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 596 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The Moon: Resources, Future Development and Settlement describes feasible human settlement of the Moon in the coming century. Small scale, tele-operated and autonomous robotic in-situ resource utilization (ISRU) projects are first, followed by electric power, communication, and transportation networks manufactured from lunar resources. These infrastructure networks are field tested an commissioned in the polar regions of the Moon, and permanent human settlements are then established. Through several phases of development, the utility networks grow, and the number of permanently inhabited bases increases to inculde all areas of interest on the Moon. The book stresses that the envisioned 'Planet Moon Project' will link the technological and cultural expertise of humanity to the virtually limitless resources of space. From that beginning, the people of the Earth reap substatntial benefits from space, and the human species will evolve into a spacefaring civilization.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 624 pp. Englisch.

Buch. Zustand: Neu. Neuware -Complex Analysis with Applications in Science and Engineering weaves together theory and extensive applications in mathematics, physics and engineering. In this edition there are many new problems, revised sections, and an entirely new chapter on analytic continuation. This work will serve as a textbook for undergraduate and graduate students in the areas noted above.Key Features of this Second Edition:Excellent coverage of topics such as series, residues and the evaluation of integrals, multivalued functions, conformal mapping, dispersion relations and analytic continuationSystematic and clear presentation with many diagrams to clarify discussion of the materialNumerous worked examples and a large number of assigned problemsSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Buch. Zustand: Neu. Neuware -In today¿s global economy, supply chains are an essential ingredient to corporate survival and growth. Operations strategy in supply chains must assume an ever-expanding and strategic role of risks that modern enterprises face when they operate in an interdependent supply chain environment. These operational and strategic facets entail a brand new set of operational problems and risks that have not always been understood or managed very well. It falls to supply chain managers to identify and to educate corporate managers on what these critical operational problems and risks involve. Supply Chain Games: Operations Management and Risk Valuation provides business students and practitioners with the means to understand, to model and to analyze these outstanding issues and problems that are the essential elements in managing supply chains today.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 528 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume is a selection of best papers presented at the CoreGRID - tegration Workshop 2006 (CGIW¿2006), which took place on 19¿20 October 2006 in Krakow, Poland. The workshop was organised by the Network of Excellence CoreGRID funded by the European Commission under the sixth Framework Programme IST-2003-2.3.2.8 starting September 1st, 2004 for a duration of four years. CoreGRID aims at strengthening and advancing scienti c and technological excellence of Europe in the area of Grid and Peer-to-Peer technologies. To achieve this objective, the network brings together a critical mass of we- established researchers from forty institutions who have constructed an - bitious joint programme of activities. The goal of the workshop is to promote the integration of the CoreGRID network and of the European research community in the area of Grid and P2P technologies, in order to overcome the current fragmentation and duplication of efforts in this area. The list of topics of Grid research covered at the workshop included but was not limited to: knowledge and data management; programming models; system architecture; Grid information, resource and work ow monitoring services; resource management and scheduling; systems, tools and environments; trust and security issues on the Grid. Priority at the workshop was given to work conducted in collaboration between partners from different research institutions and to promising research prop- als that can foster such collaboration in the future.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Buch. Zustand: Neu. Neuware -International concern in scienti c, industrial, and governmental commu- ties over traces of xenobiotics in foods and in both abiotic and biotic en- ronments has justi ed the present triumvirate of specialized publications in this eld: comprehensive reviews, rapidly published research papers and progress reports, and archival documentations. These three international publications are integrated and scheduled to provide the coherency ess- tial for nonduplicative and current progress in a eld as dynamic and complex as environmental contamination and toxicology. This series is reserved exclusively for the diversi ed literature on ¿toxic¿ chemicals in our food, our feeds, our homes, recreational and working surroundings, our domestic animals, our wildlife and ourselves. Tremendous efforts worldwide have been mobilized to evaluate the nature, presence, magnitude, fate, and toxicology of the chemicals loosed upon the earth. Among the sequelae of this broad new emphasis is an undeniable need for an articulated set of authoritative publications, where one can nd the latest important world literature produced by these emerging areas of science together with do- mentation of pertinent ancillary legislation. Research directors and legislative or administrative advisers do not have the time to scan the escalating number of technical publications that may contain articles important to current responsibility. Rather, these indiv- uals need the background provided by detailed reviews and the assurance that the latest information is made available to them, all with minimal literature searching.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -In Energiya-Buran: the Soviet Space Shuttle, the authors describe the long development path of the Soviet space shuttle system, consisting of the Energiya rocket and the Buran orbiter. The program eventually saw just one unmanned flight in November 1988 before the end of the Cold War and the collapse of the Soviet Union sealed its fate.After a Foreword provided by lead Buran test pilot Igor Volk, the authors look at the experience gradually accumulated in high-speed aeronautics with the development of various Soviet rocket planes and intercontinental cruise missiles between the 1930s to 1950s and the study of several small spaceplanes in the 1960s. Next the authors explain how the perceived military threat of the US Space Shuttle led to the decision in February 1976 to build a Soviet equivalent, and explore the evolution of the design until it was frozen in 1979. Following this is a detailed technical description of both Energiya and Buran and a look at nominal flight scenarios and emergency situations, highlighting similarities and differences with the US Space Shuttle.The authors then expand on the managerial aspects of the Energiya-Buran program, sum up the main design bureaus and production facilities involved in the project and describe the infrastructure needed to transport the hardware and prepare it for launch at the Baikonur cosmodrome. They go on to detail the selection and training of teams of civilian and military test pilots for Buran, crew assignments for the first manned missions and preparatory flights aboard Soyuz spacecraft.Next the focus turns to the extensive test program that preceded the first flight of Buran, notably the often trouble-plagued test firings of rocket engines, the first flight of Energiya with the enigmatic Polyus payload, test flights of subscale models and atmospheric approach and landing tests. After an analysis of Western speculation on the Soviet space shuttle effort in the pre-glasnost era, a detailed account is given of final preparations for the maiden flight of Buran and the mission itself.In the final chapters the authors look at the gradual demise of the project in the early 1990s, the fate of the Soviet orbiters and their cosmodrome infrastructure, cancelled missions, and the many planned derivatives of the Energiya rocket. Attention is also paid to technological spin-offs such as the Zenit and Sea Launch projects and the RD-180 and RD-191 rocket engines. Finally, an overview is given of alternative spaceplane proposals during and after the Buran era, including the MAKS air-launched spaceplane, the Kliper spacecraft and various single-stage-to-orbit systems.The book closes off with key specifications of the Energiya-Buran system, short biographies of the Buran pilots, an extensive list of Russian acronyms, a short bibliographical essay and a detailed index. Based largely on Russian sources, it is richly illustrated with some 250 pictures and diagrams.Although Energiya-Buran was primarily a program of unfulfilled promises and shattered dreams, it represented a major technological breakthrough for the Soviet Union and its story deserves to be told.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 552 pp. Englisch.

Buch. Zustand: Neu. Neuware -Microstructured Polymer Optical Fibres describes the optical properties of microstructured fibres, how they are made and modelled, and outlines some potential applications. These applications include areas where polymer fibres are already used, such as high-data rate transmission for Fibre-to-the Home or within cars, as well as completely new areas such as the photonic bandgap transmission of 'difficult' wavelengths.Emphasising a conceptual understanding of the underlying physics, Microstructured Polymer Optical Fibres is clearly written, and includes numerous illustrations. It provides an excellent overview of the latest developments in the field, making them accessible to industry, technical and research audiences.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Buch. Zustand: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 556 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Digg^f^g it up Down Under is the first book in a new series of Global Cultural Heritage Manuals being published by Springer. The aim of this series is to provide the essential information needed to conduct archaeological fieldwork in various parts of the world. This series of hands-on field manuals have been written for both undergraduate and graduate students, and for emerging professionals. Each book constitutes a step-by-step guide to undertaking and successfully completing cultural heritage fieldwork in a particular country or region. The Global Cultural Heritage Manuals Series fills the need for a cohesive series of regional field manuals for archaeologists. While there are a number of useful books that provide an introduction to archaeological techniques, these books tend to focus primarily on conditions in North America or Britain, and this makes them of limited value to archaeologists working in other parts of the world. The Global Cultural Heritage Manuals Series fills this gap, not only through providing information specifically crafted to the ethical, legislative and environ mental conditions of each region or country, but also by providing the detailed advice on the complex process of undertaking archaeological fieldwork in dif ferent parts of the world. The books in this series are structured so they guide practitioners through the entire archaeological process, from research design and obtaining funding, visas and permissions, to site recording, analysis, report writing and other forms of publication.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 352 pp. Englisch.

Buch. Zustand: Neu. Neuware -The Akaike information criterion (AIC) derived as an estimator of the Kullback-Leibler information discrepancy provides a useful tool for evaluating statistical models, and numerous successful applications of the AIC have been reported in various fields of natural sciences, social sciences and engineering.One of the main objectives of this book is to provide comprehensive explanations of the concepts and derivations of the AIC and related criteria, including Schwarz¿s Bayesian information criterion (BIC), together with a wide range of practical examples of model selection and evaluation criteria. A secondary objective is to provide a theoretical basis for the analysis and extension of information criteria via a statistical functional approach. A generalized information criterion (GIC) and a bootstrap information criterion are presented, which provide unified tools for modeling and model evaluation for a diverse range of models, including various types of nonlinear models and model estimation procedures such as robust estimation, the maximum penalized likelihood method and a Bayesian approach.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Buch. Zustand: Neu. Neuware -Nanotechnology provides us with tools to create functional materials, devices, and systems by controlling materials at the atomic and molecular scales by making use of novel properties and phenomena. Considering that most chemical and biological sensors, as well as many physical sensors, depend on interactions occurring within the nanoscale range, the impact that nanotechnology will have on the sensor world is significant. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. Nanostructured materials will be increasingly used for the development of next-generation of chemical, physical and biosensors, attracting interests in the scientific and industrial communications. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Buch. Zustand: Neu. Neuware -Capillary Forces in Microassembly discusses the use of capillary forces as a gripping principle in microscale assembly. Clearly written and well-organized, this text brings together physical concepts at the microscale with practical applications in micromanipulation. Throughout this work, the reader will find a review of the existing gripping principles, elements to model capillary forces as well as descriptions of the simulation and experimental test bench developed to study the design parameters. Using well-known concepts from surface science (such as surface tension, capillary effects, wettability, and contact angles) as inputs to mechanical models, the amount of effort required to handle micro-components is predicted. These developments are then applied in a case study concerning the pick and place of balls in a watch ball bearing.Researchers and engineers involved in micromanipulation and precision assembly will find this a highly useful reference for microassembly system design and analysis.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 288 pp. Englisch.

Buch. Zustand: Neu. Neuware -While it is tempting to label computational materials modeling as an emerging field of research, the truth is that both in nature and foundation, it is just as much an established field as the concepts and techniques that define it. It is the recent enormous growth in computing power and communications that has brought the activity to the forefi-ont, turning it into a possible com ponent of any modem materials research program. Together with its increased role and visibility, there is also a dynamic change in the way computational modeling is perceived in such a vast field as materials science with its wide range of length and time scales. As the pace of materials research accelerates and the need for often inaccessible information continues to grow, the de mands and expectations on existing modeling techniques have progressed that much faster. Primarily because there is no one technique that can provide all the answers at every length and time scale in materials science, excessive expectations of computational materials modeling should be avoided if pos sible. While it is apparent that computational modeling is the most efficient method for dealing with complex systems, it should not be seen as an alter native to traditional experimentation. Instead there is another option, which is perhaps the one that is most likely to become the defining characteristic of computational materials modeling.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 508 pp. Englisch.

Buch. Zustand: Neu. Neuware -Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.This book will bring current information on the presentation and management of patients with brain metastases, providing available data, giving guidelines that can be applied in day to day practice, updated information for neuro-surgeons, radiation oncologists, medical oncologists, and neuro-oncologists, as well as an overview for physicians in training.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Buch. Zustand: Neu. Neuware -Bringing together top-level contributions on all aspects of the subject, this book provides an overview of the recent advances in the genetics of respiratory control in health and disease. It also shows how combined studies in humans and mouse models have helped to improve our understanding of the mechanisms that underlie genetically determined respiratory control disorders with the goal of developing new therapeutic interventions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 360 pp. Englisch.

Buch. Zustand: Neu. Neuware -Bulk metallic glasses are a new emerging field of materials with many desirable and unique properties, such as high strength, good hardness, good wear resistance, and high corrosion resistance that can be produced in near net shape components. These amorphous materials have many diverse applications from structural applications to biomedical implants.A complete overview of bulk metallic glasses is presented: the principles of alloy design, glass formation, processing, atomistic modeling, computer simulations, mechanical properties and microstructures.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Buch. Zustand: Neu. Neuware -Projecting correctional facility-based health care into the community arena, Public Health Behind Bars: From Prisons to Communities examines the burden of illness in the growing prison population, and analyzes the considerable impact on public health as prisoners are released. More than forty practitioners, researchers, and scholars in correctional health, mental health, law, and public policy make a timely case for correctional health care that is humane for those incarcerated and beneficial to the communities they reenter. These authors offer affirmative recommendations toward that evolutionary step.Chapter authors identify the most compelling health problems behind bars (including communicable disease, mental illness, addiction, and suicide), pinpoint systemic barriers to care, and explain how correctional medicine can shift from emergency or crisis care to primary care and prevention. In addition, strategies are outlined that link community health resources to correctional facilities so that prisoners can transition to the community without unnecessarily taxing public resources or falling through the cracks. Between the authors¿ research findings and practical suggestions, readers will find realistic answers to these and similar questions:Can transmission of HIV, tuberculosis, and other communicable diseases be reduced and prevented among prisoners How can correctional facilities treat addiction more effectively What can be done to improve diagnosis and treatment of psychiatric disorders Can correctional care benefit from quality management and performance measurement How can care be coordinated between correctional and community health care providers What are the health risks to communities if action is not taken Public Health BehindBars: From Prisons to Communities is a challenge of immediate interest to readers in correctional health and medicine, public and community health, health care administration and policy, and civil rights.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 596 pp. Englisch.

Buch. Zustand: Neu. Neuware -Like other fields of science, wildlife conservation is a changing field. Threats facing wild populations of apes and other species, say 20 years ago, are likely not the same ones most pressing today, and even where threats have remained unchanged, more effective means of addressing them may be available now. Conservation scientists have learned from many years of experience, and both theoretical and technological advances today provide conservation tools not available in the past. This volume identifies the primary problems faced in conserving wild populations of gorillas throughout Africa, pinpointing new approaches to solving these problems and outlining the increased role that zoos can play in gorilla conservation. It includes expertise of field scientists in a variety of disciplines to discuss current conservation threats, novel approaches to conservation, and potential solutions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 384 pp. Englisch.

Buch. Zustand: Neu. Neuware -Scientific progress has been rapid in lysosomal biology during the last six decades. Its application to human disease is nothing less than spectacular. In no other group of disorders has knowledge and clinical utility progressed so speedily. Recall that the organelle was described in just 1955. Since then, the biochemical alterations and storage materials were described, the enzyme deficiencies discovered, the gene coding of these glycoproteins cloned and thousands of mutations defined. These advances have resulted in highly improved diagnosis for more than 50 diseases. For five diseases, including the most common lysosomal storage disorder, molecular therapy is a reality, extremely effective and very safe. This higher plateau of medical approaches to human disease is something to which all translational scientists aspire and only a few actually witness. The relief of pain and suffering is a tribute to the ideas and work of many dedicated investigators. Much of that work is presented in this text. Despite our ability to treat some of these diseases through enzyme replacement therapy (ERT) and, accurately define different diseases that look alike, there is much to be learned about lysosomal disease. With each step up the barrier to knowledge, a new point of view is attained, a fresh perspective. Much is seen more clearly and many ¿allegories of the cave¿ are dispelled forever. Yet, our new view demands a new vision drawing us to find better definitions of what we see. This is how it has been with lysosomal diseases.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 584 pp. Englisch.

Buch. Zustand: Neu. Neuware -A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative Role Of Ids In Osteoclastogenesis.- Functional Genetic and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic Regulation Of Bone Development.- Pth Regulates The Hematopoietic Stem Cell Niche In Bone.- Regulation Of Hematopoietic Stem Cells In The Osteoblastic Niche.- The Chemokine Cxcl12 And Regulation Of Hsc And Lymphocyte Development In The Bone Marrow Niche.- Osteoclast Precursor Cells.- Interaction with estrogen receptors as treatment of arthritis and osteoporosis.- Novel Signaling Pathways And Therapeutic Targets In Osteoclasts.- The Enigmatic Function of TREM-2 in Osteoclastogenesis.- Role of cell-matrix interactions in osteoclast differentiation.- Positive and negative roles of IL-6, STAT3 and SOCS3 in inflammatory arthritis.- Control of Osteoclast activity and bone loss by IKK subunits: new targets for therapy.- Targeting Osteoporosis And Rheumatoid Arthritis By Active Vaccination Against Rankl.- RANKL Inhibition: From Mice to Men (and Women).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 176 pp. Englisch.

Buch. Zustand: Neu. Neuware -Performance optimization is vital in the design and operation of modern engineering systems, including communications, manufacturing, robotics, and logistics. Most engineering systems are too complicated to model, or the system parameters cannot be easily identified, so learning techniques have to be applied.This is a multi-disciplinary area which has been attracting wide attention across many disciplines. Areas such as perturbation analysis (PA) in discrete event dynamic systems (DEDSs), Markov decision processes (MDPs) in operations research, reinforcement learning (RL) or neuro-dynamic programming (NDP) in computer science, identification and adaptive control (I&AC) in control systems, share the common goal: to make the 'best decision' to optimize system performance.This book provides a unified framework based on a sensitivity point of view. It also introduces new approaches and proposes new research topics within this sensitivity-based framework.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 588 pp. Englisch.

Buch. Zustand: Neu. Neuware -Information Systems Development (ISD) progresses rapidly, continually creating new challenges for the professionals involved. New concepts, approaches and techniques of systems development emerge constantly in this field. Progress in ISD comes from research as well as from practice. The aim of the Conference is to provide an international forum for the exchange of ideas and experiences between academia and industry, and to stimulate exploration of new solutions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 568 pp. Englisch.

Buch. Zustand: Neu. Neuware -Since the publication of the first edition of Cardiac Pacing for the Clinician, the use of implantable cardiac devices has expanded rapidly. Certain classes of devices such as implantable loop recorders and cardiac resynchronization pacing systems were not commonly used when the first edition was published, and recent studies have shown that implantable cardioverter defibrillators are beneficial in large, previously unrecognized patient populations at risk for sudden death. In order to meet this demand, cardiologists without special training in electrophysiology or pacing are implanting an increasing number of cardiac devices. It is in this rapidly evolving setting that Cardiac Pacing for the Clinician, Second Edition is being undertaken.The main focus of this volume will be to provide a practical discussion of the ¿nuts and bolts¿ of implantable cardiac devices. The target audience will be cardiologists in practice and in training as well as nurses, technologists and industry. In addition, it will benefit physicians preparing for certification.Additions to the new edition will include: Chapters discussing new cardiac devices; Implantation of Left Ventricular Leads for Cardiac Resynchronization Pacing Systems; Identification of Candidates for Cardiac Resynchronization Therapy; Follow-Up Issues in Cardiac Resynchronization Therapy; Implantable Loop Recorders.Updates to the existing chapters will include: New Trial Information & Follow-Up of the Newest Generation of Defibrillators; Use of Defibrillators in Patients at Increased Risk for Sudden Cardiac Death due to Long QT Syndrome, Brugada Syndrome and Congenital Heart Disease; Updates to Lead Extraction ¿ New Techniques and Tools; Cardiac Pacing chapter will shift focus to Cardiac Devices.This new edition of Cardiac Pacing for the Clinician, Second Edition will become a valuable resource to the general cardiologist and cardiology fellow by providing practicalinformation for managing patients with complex cardiac devices.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 764 pp. Englisch.