Springer us jul 1993 (6 Ergebnisse)

Buch. Zustand: Neu. Neuware - In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA. …

Buch. Zustand: Neu. Neuware - Multiprocessing: Trade-Offs in Computation and Communication presents an in-depth analysis of several commonly observed regular and irregular computations for multiprocessor systems. This book includes techniques which enable researchers and application developers to quantitatively determine the effects of algorithm data dependencies on execution time, on communication requirements, on processor utilization and on the speedups possible. Starting with simple, two-dimensional, diamond-shaped directed acyclic graphs, the analysis is extended to more complex and higher dimensional directed acyclic graphs. The analysis allows for the quantification of the computation and communication costs and their interdependencies. The practical significance of these results on the performance of various data distribution schemes is clearly explained. Using these results, the performance of the parallel computations are formulated in an architecture independent fashion. These formulations allow for the parameterization of the architecture specitific entities such as the computation and communication rates. This type of parameterized performance analysis can be used at compile time or at run-time so as to achieve the most optimal distribution of the computations. The material in Multiprocessing: Trade-Offs in Computation and Communication connects theory with practice, so that the inherent performance limitations in many computations can be understood, and practical methods can be devised that would assist in the development of software for scalable high performance systems.…

Buch. Zustand: Neu. Neuware - The Royal Society has initiated a series of meetings to discuss the effect advances in technology will have on our way of life in the next century. The two previous meetings have been concerned with housing and waste treat ment. The subject of the third meeting, communications, is no less critical to life, but it offers particular problems and uncertainties, especially in the forecasting of future trends. Indeed, some have doubted if there can be profitable debate on long-term development in such a fast-moving field. The importance of the topic justifies an attempt, and the reader will judge whether the authors have met the challenge. Communications today bears little resemblance to that of the 1970s. Then we knew about satellites and optical fibres, and we had seen lasers and silicon chips, but most of us could never imagine the potential of the new technologies within our grasp. We had also not assessed the thirst of the popUlation for more and better ways of talking and writing to each other. It was the combination of market need and technical capability that created the com munications revolution. …

Buch. Zustand: Neu. Neuware - Effective Polynomial Computation is an introduction to the algorithms of computer algebra. It discusses the basic algorithms for manipulating polynomials including factoring polynomials. These algorithms are discussed from both a theoretical and practical perspective. Those cases where theoretically optimal algorithms are inappropriate are discussed and the practical alternatives are explained. Effective Polynomial Computation provides much of the mathematical motivation of the algorithms discussed to help the reader appreciate the mathematical mechanisms underlying the algorithms, and so that the algorithms will not appear to be constructed out of whole cloth. Preparatory to the discussion of algorithms for polynomials, the first third of this book discusses related issues in elementary number theory. These results are either used in later algorithms (e.g. the discussion of lattices and Diophantine approximation), or analogs of the number theoretic algorithms are used for polynomial problems (e.g. Euclidean algorithm and p-adic numbers). Among the unique features of Effective Polynomial Computation is the detailed material on greatest common divisor and factoring algorithms for sparse multivariate polynomials. In addition, both deterministic and probabilistic algorithms for irreducibility testing of polynomials are discussed. …

Buch. Zustand: Neu. Neuware - - . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . -. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.…

Buch. Zustand: Neu. Neuware - The previous volume of this series on soft tissue sarcomas highlighted the importance of the multidisciplinary approach to treatment, the focus of which is continued in the present edition. Proper diagnosis and staging remain the cornerstone of the treatment strategy. Sophisticated histopathology techniques and growing consensus on grading systems have further increased the importance of the histopathologist in providing estimates of the prognosis of the patient as well as providing data for the planning of treatment strategy. The use of cytogenetics is relatively new in this field. This might enable the distinction of subgroups in specific histological tumor types. Furthermore, molecular biological studies not only help to reveal inherited predispositions and details in oncogenesis in tumor development, but they may also provide additional predictive factors for tumor behavior. Further data on treatment strategy will be provided by diagnostic imaging, a field in which the role of magnetic resonance imaging is rapidly developing. As far as actual treatment is concerned, surgery still provides the major chance for cure. In view of the endeavor to be as sparing as possible, the addition of radiotherapy to surgery is of utmost importance. Usually radiotherapy is given after surgery, but the optimal sequence of the two modalities still needs to be defined. The combined use of surgery with radiotherapy and/or chemotherapy does have an impact on wound healing. …