springer us jan 2003 (8 Ergebnisse)

Buch. Zustand: Neu. Neuware - It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Buch. Zustand: Neu. Neuware - Ecology and economics have Greek roots in oikos for 'household', logos for 'study', and nomics for 'management'. Thus, ecology and economics should have complemented one another for a proper growth and development without destruction, but, unfortunately, rapid industrialization, lure for fast financial gains, and commercialization activities have led to a widespread surge in pollution load, environmental degradation, habitat destruction, rapid loss ofbiodiversity, sudden rise in rate ofextinction ofmany wildlife and wild relatives of domesticated animals and cultivated cereals and other plants, global climate changes creating global rise in temperature, and CO levels and increased ultraviolet B at ground 2 level. Although these threats to human health have led us to look to ecology for their solutions and guidance for sustainable development without destruction, the industrial and technology houses are looking for alternative methods of development and resource use methods. The two global conferences of the United Nations in 1972 and 1992, and international programs of Man and the Biosphere (MAB), International Biological Program (IBP), International Geosphere, Biosphere program (lGBP), and World Conser vation Union (IUCN), of different commissions, United Nations Environmental Program (UNEP) efforts, Ramsar Conventions (for wetlands), and World Wide fund for Nature (WWF) (for nature in general and wildlife in particular) have focused attention of ecologists, naturalists, governments and Non-governmental organizations (NGOs) toward better conservation.

Buch. Zustand: Neu. Neuware - The human immunodeficiency viruses (HIVs), in particular HIV-1, are the causative agent responsible for the current worldwide epidemic of acquired immunodeficiency syndrome (AIDS). A major effort has thus been underway over the past two decades to understand and control this pathogen. During this time, an enormous knowledge base has accumulated regarding the role of viral factors in the HIV-1 life cycle, and the interaction of HIV-1 with the host cell is becoming increasingly understood. Certain features of HIV, for example its ability to infect non-dividing cells, are being exploited in the development of novel gene therapy vehicles. This volume provides an overview of the current information regarding the HIV replication cycle and will serve as an introduction to subsequent chapters that address specific aspects of lentiviral-based gene therapy.

Buch. Zustand: Neu. Neuware - Foldable Flex and Thinned Silicon Multichip Packaging Technology presents newly emerging methods used to make stacked chip packages in the so-called 2-1/2 D technology (3-D in physical format, but interconnected only through the circuits on folded flex). It is also being used in single chip packages where the thinness of the chips and the flex substrate made packages significantly thinner than through any other means.

Buch. Zustand: Neu. Neuware - Stuart Wolf This book originated as a series of lectures that were given as part of a Summer School on Spintronics in the end of August, 1998 at Lake Tahoe, Nevada. It has taken some time to get these lectures in a form suitable for this book and so the process has been an iterative one to provide current information on the topics that are covered. There are some topics that have developed in the intervening years and we have tried to at least alert the readers to them in the Introduction where a rather complete set of references is provided to the current state of the art. The field of magnetism, once thought to be dead or dying, has seen a remarkable rebirth in the last decade and promises to get even more important as we enter the new millennium. This rebirth is due to some very new insight into how the spin degree of freedom of both electrons and nucleons can play a role in a new type of electronics that utilizes the spin in addition to or in place of the charge. For this new field to mature and prosper, it is important that students and postdoctoral fellows have access to the appropriate literature that can give them a sound basis in the funda mentals of this new field and I hope that this book is a very good start in this direction.

Buch. Zustand: Neu. Neuware - Coded Modulation Systems is an introduction to the subject of coded modulation in digital communication. It is designed for classroom use and for anyone wanting to learn the ideas behind this modern kind of coding. Coded modulation is signal encoding that takes into account the nature of the channel over which it is used. Traditional error correcting codes work with bits and add redundant bits in order to correct transmission errors. In coded modulation, continuous time signals and their phases and amplitudes play the major role. The coding can be seen as a patterning of these quantities. The object is still to correct errors, but more fundamentally, it is to conserve signal energy and bandwidth at a given error performance. The book divides coded modulation into three major parts. Trellis coded modulation (TCM) schemes encode the points of QAM constellations; lattice coding and set-partition techniques play major roles here. Continuous-phase modulation (CPM) codes encode the signal phase, and create constant envelope RF signals. The partial-response signaling (PRS) field includes intersymbol interference problems, signals generated by real convolution, and signals created by lowpass filtering. In addition to these topics, the book covers coding techniques of several kinds for fading channels, spread spectrum and repeat-request systems. The history of the subject is fully traced back to the formative work of Shannon in 1949. Full explanation of the basics and complete homework problems make the book ideal for self-study or classroom use.

Buch. Zustand: Neu. Neuware - Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor mation is beginning to provide tangible targets towards manipulating cardiac func tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben eficial response under many conditions, it can be highly deleterious and inappropri ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben eficial.

Buch. Zustand: Neu. Neuware - Over the past thirty-five years, a substantial amount of theoretical and empirical scholarly research has been developed across the discipline domains of Transportation. This research has been synthesized into a systematic handbook that examines the scientific concepts, methods, and principles of this growing and evolving field. The Handbook of Transportation Science outlines the field of transportation as a scientific discipline that transcends transportation technology and methods. Whether by car, truck, airplane - or by a mode of transportation that has not yet been conceived - transportation obeys fundamental properties. The science of transportation defines these properties, and demonstrates how our knowledge of one mode of transportation can be used to explain the behavior of another. Transportation scientists are motivated by the desire to explain spatial interactions that result in movement of people or objects from place to place. Its methodologies draw from physics, operations research, probability and control theory.