springer new york springer us jul 2009 (10 Ergebnisse)

Buch. Zustand: Neu. Neuware -Do not learn the tricks of the trade, learn the trade I started teachinggraduate coursesin chemical sensors in early 1980s, rst as a o- quarter (30 h) class then as a semester course and also as several intensive, 4¿5-day courses. Later I organized my lecture notes into the rst edition of this book, which was published by Plenum in 1989 under the title Principles of Chemical Sensors. I started working on the second edition in 2006. The new edition of Principles of Chemical Sensors is a teaching book, not a textbook. Let me explain the difference. Textbooks usually cover some more or less narrow subject in maximum depth. Such an approach is not possible here. The subject of chemical sensors is much too broad, spanning many aspects of physical and analytical chemistry, biochemistry, materials science, solid-state physics, optics, device fabrication, electrical engine- ing, statistical analysis, and so on. The challengefor me has been to present uniform logical coverage of such a large area. In spite of its relatively shallow depth, it is intended as a graduate course. At its present state the amount of material is more thancan be coveredin a one-semestercourse (45h). Two one-quartercourseswould be more appropriate. Because of the breadth of the material, the sensor course has a somewhat unexpected but, it is hoped, bene cial effect.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.

Buch. Zustand: Neu. Neuware -Starting in 1995 numerical modeling of the Earth¿s dynamo has ourished with remarkable success. Direct numerical simulation of convection-driven MHD- ow in a rotating spherical shell show magnetic elds that resemble the geomagnetic eld in many respects: they are dominated by the axial dipole of approximately the right strength, they show spatial power spectra similar to that of Earth, and the magnetic eld morphology and the temporal var- tion of the eld resembles that of the geomagnetic eld (Christensen and Wicht 2007). Some models show stochastic dipole reversals whose details agree with what has been inferred from paleomagnetic data (Glatzmaier and Roberts 1995; Kutzner and Christensen 2002; Wicht 2005). While these models represent direct numerical simulations of the fundamental MHD equations without parameterized induction effects, they do not match actual pla- tary conditions in a number of respects. Speci cally, they rotate too slowly, are much less turbulent, and use a viscosity and thermal diffusivity that is far too large in comparison to magnetic diffusivity. Because of these discrepancies, the success of geodynamo models may seem surprising. In order to better understand the extent to which the models are applicable to planetary dynamos, scaling laws that relate basic properties of the dynamo to the fundamental control parameters play an important role. In recent years rst attempts have been made to derive such scaling laws from a set of numerical simulations that span the accessible parameter space (Christensen and Tilgner 2004; Christensen and Aubert 2006).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.

Buch. Zustand: Neu. Neuware -Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma.The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 244 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book consists of a number of papers regarding the thermodynamics and structure of multicomponent systems that we have published during the last decade. Even though they involve different topics and different systems, they have something in common which can be considered as the ¿signature¿ of the present book. First, these papers are concerned with ¿difficult¿ or very nonideal systems, i. e. systems with very strong interactions (e. g. , hyd- gen bonding) between components or systems with large differences in the partial molar v- umes of the components (e. g. , the aqueous solutions of proteins), or systems that are far from ¿normal¿ conditions (e. g. , critical or near-critical mixtures). Second, the conventional th- modynamic methods are not sufficient for the accurate treatment of these mixtures. Last but not least, these systems are of interest for the pharmaceutical, biomedical, and related ind- tries. In order to meet the thermodynamic challenges involved in these complex mixtures, we employed a variety of traditional methods but also new methods, such as the fluctuation t- ory of Kirkwood and Buff and ab initio quantum mechanical techniques. The Kirkwood-Buff (KB) theory is a rigorous formalism which is free of any of the - proximations usually used in the thermodynamic treatment of multicomponent systems. This theory appears to be very fruitful when applied to the above mentioned ¿difficult¿ systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.

Buch. Zustand: Neu. Neuware -Horseshoe crabs, those mysterious ancient mariners, lured me into the sea as a child along the beaches of New Jersey. Drawn to their shiny domed shells and spiked tails, I could not resist picking them up, turning them over and watching the wondrous mechanical movement of their glistening legs, articulating with one another as smoothly as the inner working of a clock. What was it like to be a horseshoe crab, I wondered What did they eat Did they always move around together Why were some so large and others much smaller How old were they, anyway What must it feel like to live underwater What else was out there, down there, in the cool, green depths that gave rise to such intriguing creatures The only way to find out, I reasoned, would be to go into the ocean and see for myself, and so I did, and more than 60 years later, I still do.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 692 pp. Englisch.

Buch. Zustand: Neu. Neuware -Currently,there is no single source that permitscomparisonof the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our parti- lar system,missing outon theopportunityto de neunifyingthemesin viralgenome replication or bene t from the advances in other systems. For example, extraor- nary biologicaland experimentalparadigmsthat have been established overthe past 5 years for the DNA replication systems of bacteriophage T4 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the eld, as well as encourage students into this area of research. The monograph has been divided into eight parts. Chapters appearing in Parts I¿VI are intended to compare and contrast the replication and/or transcription processes and corresponding ¿players¿ of the indicated family of viruses. We are interested in the sequence of events that lead to production of mRNA and progeny genomes as well as the cis-acting elements and trans-acting factors and enzymes (viral and cellular) that are required for these processes. Chapters appearing in Part VII are - tended to providea more biochemical and biophysicalperspective of the replication and/ortranscriptionprocess. Chaptersappearingin Part VIII are intendedto provide a practical perspective on viral replication and its inhibition.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 656 pp. Englisch.

Buch. Zustand: Neu. Neuware -Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 520 pp. Englisch.

Buch. Zustand: Neu. Neuware -Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 508 pp. Englisch.

Buch. Zustand: Neu. Neuware -Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products.Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 612 pp. Englisch.

Buch. Zustand: Neu. Neuware -The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the genesis and the maintenance of synaptic connections. Genes encoding adhesive molecules make up a significant portion of the human genome, and neural CAMs even have been postulated to be a major factor in the evolution of the human brain. These are just some of the many reasons why we thought a book on neural CAMs and their role in establishing and maintaining neuronal synapses would be highly appropriate for summarizing our current state of knowledge. Without question, over the near future, additional adhesive proteins will join the ranks of synaptic CAMs and our knowledge, and how these molecules enable neurons and their targets to communicate effectively will grow.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 468 pp. Englisch.