rsc publishing nov 2010 (9 Ergebnisse)

Buch. Zustand: Neu. Neuware - This comprehensive book reviews some of the many scientific and technical challenges faced by EU Member States, stakeholder organisations and scientists while developing the first River Basin Management Plan (2009-2015) under the Water Framework Directive (WFD). It focuses on aspects of multisectoral and multidisciplinary integration and how emerging issues such as action programmes (linked to the environmental objectives of the WFD) and adaptation to climate change will be considered in the future in the context of river basin management planning. In particular, the book highlights research trends that contribute to policy developments through selected examples of projects funded by the European Commission. This publication is timely in that the science-policy interfacing is now identified as a key challenge worldwide with regard to integrated water resource management, and therefore the book will be of great interest to environmental scientists, water managers and all other stakeholders. Readers will also benefit from a better understanding of the needs, benefits and drawbacks of an established transfer mechanism of scientific outputs to policies.

Buch. Zustand: Neu. Neuware - This book is the most comprehensive recent publication on MWPs, consisting of 13 chapters, primarily involving the fundamentals, the instrumentation, and the methodologies of MWP-OES. The physical and chemical characteristics of the various MWP sources and sample introduction techniques available are all discussed as well as how these characteristics affect the design of the parts of the MWP setup with inclusion of some very recent work with MWP sources. Considerable experimental and fundamental emphasis is placed on the plasma generation as well as the experimental aspects of sample introduction in MWP spectrometry. The book firstly outlines the generation and operation of MWP discharges, and presents briefly the principles of MWP-based techniques currently in use, along with their potential benefits and limitations. It then addresses the art and science of microwave plasma generation and highlights very recent advances in the field, presenting both the fundamental properties and the design details of new microwave plasma sources. Analytical characteristics and novel applications of MWP-OES for a wide variety of sample types are also reviewed. As the book documents the latest achievements in MWP spectrometry, it should stimulate their use on a wider scale in the analytical and research laboratories and will prove useful to manufacturers of analytical instruments. This book is also aimed at academics and postgraduates embarking on work in the field of MWP source spectrometry, ICP/MWP users, analysts and research groups who want to configure their own plasma spectrometry setup, and manufacturers of plasma spectrometers and MWP devices. It will also be a useful source of information for those seeking to interface various sample introduction techniques with plasmas and for all those who would like to know more about the technique.

Buch. Zustand: Neu. Neuware - Naturally occurring compounds, or natural products, have been and continue to be an important source of commercially successful products and leads in the pharmaceutical, agrochemical and nutritional sectors. The conference Functional Molecules from Natural Sources, which was held at Magdalen College, Oxford in July 2009, set out to highlight current trends, challenges and successes in the exploitation of natural products from microbial, plant and marine sources. This book is based on the proceedings of the conference and comprises modern and emerging perspectives on natural product utilization and improved strategies for their exploitation. Several case studies on important natural product leads, or functional molecules, are presented with the strategy for their development. These detail new medical applications in the use of familiar natural molecules and advances in the understanding and manipulation of natural product biosynthesis at the genetic level. Highlights include an authoritative review of the entire field of natural anticancer agents emphasising those currently in clinical development, an account of the optimisation of the pleuromutilin antibiotic template for human use and a comprehensive description of the research programme that resulted in the discovery of platensimycin. Articles on biosynthesis include studies of the antibiotics of Streptomyces coelicolor A3(2), the anthrax siderophore petrobactin and the modification of oxidation and glycosylation events in the biosynthesis of mithramycins. Written by leading industrial and academic practitioners from each sector, the book offers authoritative updates on new approaches to the use of naturally occurring compounds within the pharmaceutical, nutraceutical and agrochemical industries.

Buch. Zustand: Neu. Neuware - Published under the auspices of both IUPAC and its affiliated body, the International Association of Chemical Thermodynamics (IACT), this book will serve as a guide to scientists or technicians who use equations of state for fluids. Concentrating on the application of theory, the practical use of each type of equation is discussed and the strengths and weaknesses of each are addressed. It includes material on the equations of state for chemically reacting and non-equilibrium fluids which have undergone significant developments and brings up to date the equations of state for fluids and fluid mixtures. Applied Thermodynamics of Fluids addresses the needs of practitioners within academia, government and industry by assembling an international team of distinguished experts to provide each chapter. The topics presented in the book are important to the energy business, particularly the hydrocarbon economy and the development of new power sources and are also significant for the application of liquid crystals and ionic liquids to commercial products. This reference will be useful for post graduate researchers in the fields of chemical engineering, mechanical engineering, chemistry and physics.

Buch. Zustand: Neu. Neuware - Protein phosphorylation analysis is a central theme in current analytical biochemistry, cell biology and systems biology. Due to its versatility, specificity and sensitivity, mass spectrometry has developed into a key technology in this field. A set of minor and major instrumental innovations mean that mass spectrometers now exhibit a level of performance, a stability of operation, a relative ease of use, and productivity, which would once have been hard to imagine. This book guides the reader through this prolific field by presenting a collection of personal views and selected examples which cover all the important principles with a focus on electrospray ionization mass spectrometry. It covers: phosphorylation analysis at the peptide, protein and proteome level; manual and automated data evaluation; phosphopeptide enrichment; quantitative aspects; element mass spectrometry; individual analytical strategies, and hints to useful internet resources. This book provides students, graduate students, post-Docs and senior scientists from related areas with a better understanding on molecular protein phosphorylation analysis. Its highest aim is to strengthen the reader's ability to develop a personal, well-founded opinion on original manuscripts published in this field.

Buch. Zustand: Neu. Neuware - Over the last fifteen years, N-heterocyclic carbenes (NHCs) have mostly been used as ancillary ligands for the preparation of transition metal-based catalysts. Compared to phosphorus-containing ligands, NHCs tend to bind more strongly to metal centres, avoiding the necessity for the use of excess ligand in catalytic reactions. The corresponding complexes are often less sensitive to air and moisture, and have proven remarkably resistant to oxidation. Recent developments in catalysis applications have been facilitated by the availability of carbenes stable enough to be bottled, particularly for their use as organocatalysts. This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium-catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Moreover, the biological activity of NHC-containing complexes, as well as an overview of their theoretical aspects are included. Such metal species are further examined, not only in terms of their catalytic applications, but also of their stereoelectronic parameters and reactivity/stability. Finally, special attention is given to the hot topic of organocatalysis. The book will be of interest to postgraduates, academic researchers and those working in industry.

Buch. Zustand: Neu. Neuware - Solar photovoltaics is one of the most promising renewable energy technologies, producing electricity on site directly from solar radiation without harming the environment or depletion of materials. The Building Integrated Photovoltaic Thermal (BIPVT) system is a technology which merges PV and thermal systems simultaneously providing both electric and thermal energy. Through this combination more energy is generated per unit surface area in comparison to the standalone photovoltaics system. Benefits of the BIPVT system include: significantly increased electrical performance, faster payback than traditional systems, negligible impact on the environment, the product is easier and less expensive to install and low maintenance is required. This book describes recent developments in PV technologies, the solar radiation available on the earth, various BIPVT systems and their applications, energy and exergy analysis, carbondioxide migration and credit earned, life cycle cost analysis and life cycle conversion efficiency. Presently there is no one single book that covers all basic and advanced concepts related to the implementation of solar energy for the passive heating and cooling of buildings. In addition to basic and advanced concepts, the book includes modelling and analysis and ongoing research in the area of BIPVT. Building Integrated Photovoltaic Thermal Systems will be essential reading for students, scientists and engineers involved in energy studies, architecture and building design.

Buch. Zustand: Neu. Neuware - Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

Buch. Zustand: Neu. Neuware - Chemical biology is an emerging field at the interface between chemistry and biology that utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing drug discovery productivity challenges. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of improved target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules applicable to many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is beginning to emerge as a key discipline within 21st century drug discovery and the purpose of this book is to highlight a number of the most important developments.