Terence e hébert (15 Ergebnisse)
Sprache: Englisch
Verlag: Humana, 2016
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
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Zustand: New. In.
Sprache: Englisch
Verlag: Humana, 2014
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Hardcover
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Sprache: Englisch
Verlag: Springer US, 2016
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Softcover
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Taschenbuch. Zustand: Neu. Nuclear G-Protein Coupled Receptors | Methods and Protocols | Terence E. Hébert (u. a.) | Taschenbuch | xv | Englisch | 2016 | Springer US | EAN 9781493955466 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann…[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer New York, Springer US, 2016
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Softcover
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems. To date, the best-characterized intracr…ine signaling system is that of angiotensin II (Ang II), covered in depth in various chapters. Methodology to study the subcellular localization and function of GPCRs and other signaling systems is provided, as well as numerous chapters focusing on methods designed to understand signaling mediated by nuclear and other internal GPCRs. Methods are also described to study the formation of second messengers such as cAMP and to study the trafficking of receptors from the cell surface. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Nuclear G-Protein Coupled Receptors: Methods and Protocols seeks to serve both professionals and novices with state-of-the-art approaches to characterize what is becoming a common theme in cellular signaling.
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Taschenbuch. Zustand: Neu. GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity | Denis J. Dupré (u. a.) | Taschenbuch | Subcellular Biochemistry | viii | Englisch | 2014 | Springer | EAN 9789401780995 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[…dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer New York, 2014
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Hardcover
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Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems. To date, the best-characterized intracr…ine signaling system is that of angiotensin II (Ang II), covered in depth in various chapters. Methodology to study the subcellular localization and function of GPCRs and other signaling systems is provided, as well as numerous chapters focusing on methods designed to understand signaling mediated by nuclear and other internal GPCRs. Methods are also described to study the formation of second messengers such as cAMP and to study the trafficking of receptors from the cell surface. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Nuclear G-Protein Coupled Receptors: Methods and Protocols seeks to serve both professionals and novices with state-of-the-art approaches to characterize what is becoming a common theme in cellular signaling.
- Hardcover
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCR…s are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally Therefore, the topics to be covered in this book are: 1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis; 2) Assembly of signalling complexes, or subunits of the complex and their organization; 3) GPCR oligomerization; 4) GPCR trafficking; 5) Problems of trafficking: pharmacological chaperones to the rescue. Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again Pharmacological chaperones may just be part of the answer to this question.
Sprache: Englisch
Verlag: Springer New York, Springer New York, 2014
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Hardcover
Anbieter: AHA-BUCH GmbH, Einbeck, DeutschlandAHA-BUCH GmbH
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems. To date, the best-characterized intracrine sig…naling system is that of angiotensin II (Ang II), covered in depth in various chapters. Methodology to study the subcellular localization and function of GPCRs and other signaling systems is provided, as well as numerous chapters focusing on methods designed to understand signaling mediated by nuclear and other internal GPCRs. Methods are also described to study the formation of second messengers such as cAMP and to study the trafficking of receptors from the cell surface. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Nuclear G-Protein Coupled Receptors: Methods and Protocols seeks to serve both professionals and novices with state-of-the-art approaches to characterize what is becoming a common theme in cellular signaling.
- Softcover
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity In order to answer this question, we need to under…stand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again Pharmacological chaperones may just be part of the answer to this question.
Gpcr Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity
Dupré, Denis J. (Editor)/ Hébert, Terence E. (Editor)/ Jockers, Ralf (Editor)
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Paperback. Zustand: Brand New. 2012 edition. 308 pages. 9.30x6.20x0.70 inches. In Stock.
Sprache: Englisch
Verlag: Humana Pr Inc, 2014
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Hardcover
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GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity: Vol 63
Dupre, Denis J. (Editor)/ Hebert, Terence E. (Editor)/ Jockers, Ralf (Editor)
- Hardcover
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Hardcover. Zustand: Brand New. 2012 edition. 307 pages. 9.45x6.30x0.71 inches. In Stock.
Sprache: Englisch
Verlag: Humana Press Inc., 2014
Serie: Methods in Molecular Biology, Buch 62 von 382. Buch 62 von 382 - Methods in Molecular Biology
- Hardcover
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Zustand: New. Editor(s): Allen, Bruce Gordon; Hebert, Terence E. Series: Methods in Molecular Biology. Num Pages: 230 pages, 28 black & white illustrations, 15 colour illustrations, 9 black & white tables, biograph. BIC Classification: PSBC. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 14. Weight in Grams: 652…. . 2014. Hardback. . . . . Books ship from the US and Ireland.
