Taro noguchi (15 Ergebnisse)

Paperback. Zustand: Used-Very Good. Pap. Slight shelf-wear. Plastic on cover is starting to peel at top back edge. Else clean copy.

Paperback. Zustand: Good. Ex-library copy with usual markings. Shows minor wear.

Paperback. Zustand: Very Good. 139 pp., Very slight evidence of reading wear. 8878380377 4to.

Zustand: Buone. inglese Condizioni dell'esterno: Buone Condizioni dell'interno: Buone.

Zustand: New.

Zustand: New. In English.

Zustand: New.

Zustand: New. In English.

Zustand: As New. Unread book in perfect condition.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an -tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.…

Paperback. Zustand: Brand New. reprint edition. 96 pages. 9.25x6.10x0.28 inches. In Stock.

Hardcover. Zustand: Brand New. 96 pages. 9.25x6.10x0.55 inches. In Stock.

Gebundene Ausgabe. Zustand: Neu. Nominated as an outstanding Ph.D. thesis by Kyoto University Describes a pioneering chemistry-based screening process for drug discovery Provides valuable insights for the field of organic chemistry, especially regarding the total synthesis of natural products and proteins Sprache: Englisch Gewicht in Gramm: 266.…

folio. pp. 139. numerous colour illus. wrs.

Gebundene Ausgabe. Zustand: Neu. 94 Seiten; V1731 Sprache: Deutsch Gewicht in Gramm: 454.