Shaffer philip a (5 Ergebnisse)

J. Biol. Chem., 48/2. - October 1921, 8°, pp.423-428, Abbildungen, Tab., orig. Broschur.

J. Biol. Chem., 18/3. - August 1914, 8°, pp.525-540, orig. Broschur.

J. Biol. Chem., 47/2. - July 1921, 8°, pp.433-473, orig. Broschur. Philip A. Shaffer (1881-1960) "first worked with Otto Folin and his first scientific publication, in 1901, concerned the quantitative determination of uric acid in urine. Later papers were published which dealt both with broad concepts of metabolism over a wide field, and with specific chemical methods of study. One of his early important contributions was his study of metabolism in typhoid fever, which lead to the development of the Coleman-Shaffer high caloric diet in the treatment of that disease. Interest then shifted to relationships of carbohydrate and fat metabolism, with special emphasis on the significance of ketosis. In these studies he collaborated with many of his students and junior staff members . Of special interest, Shaffer developed a rapid method of measuring the sugar in small amounts of blood. Banting and Best used his finding in their discovery and assay of insulin. A case arose not long thereafter where insulin was needed to save the lives of two infants in the St. Louis Children's Hospital. Shaffer followed Banting and Best's method. That experience quickly led to understanding that strong acid is needed in the original extraction from the pancreas, and that insulin is a protein and it could be highly concentrated by isoelectric precipitation. At that time, such facts were unknown, either to the Toronto investigators or to the Eli Lilly scientists, who were encountering difficulty in getting consistently potent insulin preparations by the original method. Shaffer's contributions hastened the commercial production of insulin. In his later years, Shaffer became interested in oxidation-reduction reactions, and in this area his contributions were also of significance." Alexis F. Hartmann, Sr., Carl F. Cori, and Joseph Erlanger.…

J. Biol. Chem., 73/ 1. Baltimore, The Waverly Press. Inc., May, 1927, 8°, pp.335-361, orig. Broschur. and "A Condenser unit for use in the dermination of lactic acid" by H.A.Davenport & Margherita Cotonio.

J. Biol. Chem., 54/2. - July 1921, 8°, pp.399-441, 10 Tab., orig. Broschur.