Roberto ceriani (14 Ergebnisse)
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Taschenbuch. Zustand: Neu. Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment | Roberto L. Ceriani | Taschenbuch | xi | Englisch | 2012 | Springer | EAN 9781461360384 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[d…ot]com | Anbieter: preigu.
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Today, advances in the area of immunology and breast cancer are made at an increasing rate, yielding an amount of information that can become unwieldy. The opportunity for scientists in this area of research to gather together to exchange results and… working hypotheses represents, in my belief, a very attractive proposition. With this in mind, these workshops have been convened with two year intervals for the last ten years. In each of them, selected topics have been highlighted. The present workshop underscores the large advancements made in the molecular biology of both breast cancer associated antigens and their corresponding antibodies. Understanding the genetic information for the expression of these antigens has been recently advanced leading to preparation of molecularly engineered reagents for use in vaccination, serum assays, and immunizations for novel antibody production. In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing. Clinical studies using anti-breast murine antibody continue to be carried out and are presented at this meeting establishing a base line for safety and efficaciousness in imaging and immunotherapy that it is hoped will be superseded by the humanized forms. Basic immunology and immunochemistry studies in breast cancer are also included in this workshop that demonstrate the fast pace at which this research is advancing in many laboratories worldwide.
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The convening of the 3rd International Workshop on Monoclonal Antibodies and Breast Cancer had the character of a self-search exercise. After almost a decade of research in the basic and applied aspects of the use of serological means to diagnose and… possibly treat breast cancer several milestones have been reached. Among them a clear understanding of immunopathological use and limitations of monoclonal antibodies against breast epithelium, the complete development and clinical use of immunoassays for circulating breast epithelial antigens, the striking advances in the diagnostic use of monoclonal antibodies to estrogen and progesterone receptor proteins and the first communications on proposed immunotherapeutic use of different conjugates of anti-breast antibodies. New areas of investigation have developed in our field, some which are reaching a full blossom while others are still facing obstacles and at times a re-definition of their goals and objectives. These meetings have acted in a way as a clearing house and have permitted their attendees to derive predictions that have helped shape future research and fine-tune objectives. But above all, the re-evaluation of past research at these Workshops and the renewed excitement brought to them by new information has helped generate a momentum and enthusiasm that assures for the future large scientific gains.
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Gebunden. Zustand: New. KlappentextThe 1992 session of the biennial workshop concerned with the immunology of breast cancer focused on the recent advances in understanding the molecular biology both of antigens associated with breast cancer and of their corresp.
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Session I.- Breast Mucin and Associated Antigens in Diagnosis and Therapy.- Peptide Epitopes in Breast Cancer Mucins.- Does a Novel Form of the Breast Cancer Marker Protein, MUC1, Act as a Receptor Molecule that Modulates Signal Transduction .- Cancer Metas…tasis Determined by Carbohydrate-Mediated Cell Adhesion.- Experimental Immunotherapy of Breast Cancer Using Alpha Interferon Conjugated to Monoclonal Antibody Mc5.- Circulating and Tissue Markers in the Longitudinal Management of Breast Cancer Patients.- Session II.- Engineering of Antibodies for Breast Cancer Therapy: Construction of Chimeric and Humanized Versions of the Murine Monoclonal Antibody BrE-3.- Humanization of an Anti-Mucin Antibody for Breast and Ovarian Cancer Therapy.- Towards an Immunotherapy for p185HER2 Overexpressing Tumors.- Session III.- Branching N-Linked Oligosaccharides in Breast Cancer.- Specificity of the IgG Response in Mice and Human Breast Cancer Patients Following Immunization Against Synthetic Sialyl-Tn, an Epitope with Possible Functional Significance in Metastasis.- Vaccination Against Breast Cancer - Studies in an Animal Model.- Anti-Idiotype Antibodies as Potential Therapeutic Agents for Human Breast Cancer.- The Simultaneous Expression of c-erbB-2 Oncoprotein and Laminin Receptor on Primary Breast Tumors has a Predicting Potential Analogous to that of the Lymph Node Status.- Multivariate Prognostic Model for Infiltrating Ductal Carcinoma of the Breast in the Axillary Node-Free Patient.- The Use of Monoclonal Antibody Immunoconjugates in Cancer Therapy.- Radioimmunolocalization of Breast Cancer Using BrE-3 Monoclonal Antibody.- Suppression of Human Anti-Mouse Antibody Response to Murine Monoclonal Antibody L6 by Deoxyspergualin: A Phase I Study.- Overview of Radioimmunotherapy in Advanced Breast Cancer Using 1-131 Chimeric L6.- Contributors.
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Session I.- Molecular Analysis of H23 Epithelial Tumor Antigen - Differentially Spliced Full Length cDNAs and Gene.- Characterization and Evolution of an Expressed Hypervariable Gene for Tumor-Associated Mucin, MUC-1.- Structure, Processing, Differential Gl…ycosylation and Biology of Episialin.- Molecular Cloning and Expression of Breast Mucin-Associated Antigens.- Monoclonal Antibodies Reactive with Breast Cancer, Mammary Mucins and Synthetic Peptides.- Molecular Analysis of Epitopic Heterogeneity of the Breast Mucin.- Session II.- Expression and Prognostic Significance of the Her-2/NEU Oncogene During the Evolutionary Progression of Human Breast Cancer.- Structure and Function of MFG-E8: A Novel Apical Membrane Protein of Mouse Mammary Ephelial Cells.- Targeted Lysis of Human Breast Cancer Cells by Human Effector Cells Armed with Bispecific Antibody 2B1 (ANTI-c-erbB-2/ANTI-Fcy Receptor III).- Mechanisms Controlling Steroid Receptor Binding to Specific DNA Sequences.- Session III.- Origin and Nature of the Milk Lipid Globule Membrane.- N-Linked Oligosaccharide Synthesis and Cellular Sociology.- Development of Enzyme Immunoassays for Breast Carcinoma-Associated Mucin Antigens.- Clinical Studies and New Developments with Hybri-BREScan (CA-549), A Monoclonal Assay for Breast Cancer-Associated Antigen.- Evaluation of Several Tumor Markers (MCA, CA 15.3, BCM and CA 549) in Tissue and Serum of Patients with Breast Cancer.- IMx BCM: A Novel Monoclonal Based System for the Detection of Breast Cancer Associated Mucin.- A Novel Serum Assay Using Recombinant Breast Epithelial Mucin Antigen.- Session IV.- RadioimmunoguidedTM Surgery in Breast Cancer.- Immuno-Pharmacologic Purging of Breast Cancer from Bone Marrow.- Imaging, Pharmacokinetics, Dosimetry and Antitumor Effects of Radiolabeled Anti-Breast Cancer Antibodies in Mouse and Man.- Radioimmunotherapy with I-131 Chimeric L-6 in Advanced Breast Cancer.- Contributors.
Sprache: Englisch
Verlag: Kluwer Academic Publishers, 1985
Serie: Developments in Oncology, Buch 46 von 78. Buch 46 von 78 - Developments in Oncology
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Zustand: New. Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer, held in San Francisco, California, November 8-9, 1984 Editor(s): Ceriani, Roberto L. Series: Developments in Oncology. Num Pages: 314 pages, 1, black & white illustrations. BIC Classification: MJCL. Category: (P) Professional & Vo…cational; (UP) Postgraduate, Research & Scholarly. Dimension: 234 x 156 x 20. Weight in Grams: 653. . 1985. Hardback. . . . . Books ship from the US and Ireland.
