Robert g thorne (10 Ergebnisse)

Paperback. Zustand: Very Good. No Jacket. May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less.

Paperback. Zustand: Brand New. 277 pages. 8.75x6.00x0.50 inches. In Stock.

Zustand: New. In English.

Zustand: New. In English.

Taschenbuch. Zustand: Neu. Drug Delivery to the Brain | Physiological Concepts, Methodologies and Approaches | Elizabeth C. M. De Lange (u. a.) | Taschenbuch | AAPS Advances in the Pharmaceutical Sciences Series | xxi | Englisch | 2023 | Springer | EAN 9783030887759 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 828 | Sprache: Englisch | Produktart: Bücher | The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood¿brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood-brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few.Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding ofthe many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiologicalconsiderations writtenspecifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.…

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood-brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few.Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding ofthe many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiologicalconsiderations writtenspecifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.…

Paperback. Zustand: Brand New. 2nd edition. 827 pages. 9.25x6.10x1.65 inches. In Stock.

Hardcover. Mixed Editions. The present collection includes: Six works inscribed by Ogden Nash to his wife, Frances; Three works by Nash bearing edits in Nash's hand; and 48 books inscribed by various authors to Nash (most notably, 12 books inscribed by S. J. Perelman). It also includes 132 uninscribed books not authored by Nash, 45 of which bear his ownership inscription (and 10 of which bear the ownership inscription of Frances Nash). Books written by Nash: 59 total (two of which are co-authored by another individual) Volumes edited in Nash's hand 2 volumes in publisher's bindings 1 volume in "Author's Copy" half leather binding, with dozens of pages removed (presumably to assemble a new collected edition of poems) Books inscribed to Frances Leonard Nash 5 works by Ogden Nash 4 works in original bindings 1 work in "Author's Copy" half leather binding 1 work by Anthony Trollope (The Chronicles of Barsetshire: 1. The Warden) 1 volume signed by numerous members of Little, Brown and Co. publishing staff 27 Author's copies bound in half leather, not already accounted for in list above 1 volume bound in full red leather 21 volumes, unmarked, in standard publisher's bindings Books not authored by Nash: 180 in total Volumes inscribed to Nash: 48 volumes Notably, this collection includes 12 works inscribed by S.J. Perelman Uninscribed volumes: 132 volumes 45 of these bear Ogden Nash's ownership inscription 10 of these bear Frances Leonard Nash's ownership inscription, generally from before her marriage Notably, this collection includes a first edition, first issue of The Great Gatsby with all points present, but lacking the dust jacket. To view the full inventory, please click HERE. All items are in good or better condition, unless otherwise stated. [Oversized book(s). Additional postage necessary for expedited/international orders. Economy International shipping unavailable due to size/weight restrictions. For international/expedited customers, please inquire for rates]. Shelved Amazon End-Cap. The present collection offers a window into the literary world of American poet and humorist Ogden Nash (1902-1971). It is comprised of 239 volumes published between 1886 and 1971, among which are numerous presentation and association copies. All books in the present collection come from the shared personal library of Ogden and Frances Nash. The collection spans poetry, humor, light verse, and literary criticism, and includes a significant number of first and limited editions, often in original bindings or dust jackets. Of particular note are six books inscribed by Nash to his wife, Frances (including five authored by Nash, one of which is in an "Author's Copy" half-leather binding). Included in the collection are 59 works by Nash, three of which feature edits to the text in Nash's hand. Twenty-seven of these Nash publications are Author's copies bound in half-leather. There are an additional 48 volumes bearing inscriptions to Nash from other authors and poets, most notably twelve volumes inscribed by S.J. Perelman. Among the 132 uninscribed volumes included here, 45 bear Ogden Nash's ownership inscription (10 bear the ownership inscription of Frances Nash). The number and range of authorial inscriptions represented in the present collections reflect Nash's wide-ranging literary friendships and professional associations. Notable among these are twelve warmly inscribed titles by humorist S.J. Perelman, whose acerbic wit is on display in a series of affectionate, playful, and sometimes satirical inscriptions to both Nash and his wife, Frances. These volumes also reflect Perelman and Nash's shared experiences in Hollywood and the literary scene of mid-century America. Other highlights include inscriptions from John Betjeman, Christopher Morley, E.C. Bentley, A.P. Herbert, David McCord, William Plumer Fowler, and Holger Lundbergh, among others-each evidencing Nash's influence and the esteem in which he was held across literary and cultural circles in the U.S. and the U.K. O.…