pantopoulos (4 Ergebnisse)

Zustand: New. Editor(s): Pantopoulos, Kostas; Schipper, Hyman M. BIC Classification: PSB. Category: (P) Professional & Vocational. Dimension: 256 x 176 x 29. Weight in Grams: 926. . 2011. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

Zustand: New. pp. 642.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book provides a state-of-the-art overview on the role of bioiron in health and disease. Iron is an essential constituent of simple and complex organisms and has played a critical role in the origin of life. Cells utilize iron for energy metabolism, oxygen transport, and several biochemical reactions due to its flexible coordination chemistry and its unique ability to serve both as electron donor and acceptor. The term bioiron was coined to emphasize the importance of iron in biology and medicine.Even though iron is an abundant metal, its bioavailability is limiting. This often leads to iron-deficient states, which manifest in anemia and other co-morbidities. In fact, iron deficiency is the most common medical condition worldwide. On the other hand, excess iron is potentially toxic due to its redox reactivity. Iron toxicity is illustrated in pathologies of iron overload disorders, such as hereditary hemochromatosis or iron-loading anemias. Deregulation of iron metabolism is also observed in prevalent metabolic, cardiovascular, or neurological disorders.Our knowledge of iron metabolism has dramatically increased during the last 30-40 years with the discovery of elegant iron homeostatic networks that operate at the cellular and systemic levels. These include the IRE/IRP regulatory system and the hepcidin/ferroportin axis. The iron hormone hepcidin has emerged as a master regulator of systemic iron traffic and as a pharmacological target for iron-related disorders. The book offers a comprehensive overview of the rapidly growing bioiron field and aims to attract the attention of students, basic scientists, and clinicians.

Buch. Zustand: Neu. Neuware - Recent years have witnessed an avalanche of new knowledge implicating free radicals in virtually every aspect of biology and medicine. It is now axiomatic that the regulated accumulation of reactive oxygen species (ROS) contributes to organismal health and well-being and that ROS serve as signaling molecules involved in cell growth, differentiation, gene regulation, replicative senescence and apoptosis. This book is an interdisciplinary text broken up into three consecutive volumes on the biochemistry and cellular/molecular biology of free radicals, transition metals, oxidants and antioxidants, and the role of oxidative stress in human health and disease.