Pan guoyu (3 Ergebnisse)
Sprache: Englisch
Verlag: Springer, 2019
Serie: Buch 448 von 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Erstausgabe
Anbieter: SpringBooks, Berlin, DeutschlandSpringBooks
Verkäufer/-in kontaktierenVerkäufer/-in mit 3 SternenZustand: Gebraucht
EUR 76,65
EUR 39,90 VersandVersand von Deutschland nach USAAnzahl: 1 verfügbar
Hardcover. Zustand: Very Good. 1. Auflage. Unread, some shelfwear. Immediately dispatched from Germany.
Sprache: Englisch
Verlag: Springer, 2020
Serie: Buch 448 von 544 - Advances in Experimental Medicine and Biology
- Softcover
Anbieter: AHA-BUCH GmbH, Einbeck, DeutschlandAHA-BUCH GmbH
Verkäufer/-in kontaktierenVerkäufer/-in mit 5 SternenZustand: Neu
EUR 213,99
EUR 65,05 VersandVersand von Deutschland nach USAAnzahl: 1 verfügbar
Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition a…nd efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and theirgene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions.This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Sprache: Englisch
Verlag: Springer, Springer, 2019
Serie: Buch 448 von 544 - Advances in Experimental Medicine and Biology
- Hardcover
Anbieter: AHA-BUCH GmbH, Einbeck, DeutschlandAHA-BUCH GmbH
Verkäufer/-in kontaktierenVerkäufer/-in mit 5 SternenZustand: Neu
EUR 225,03
EUR 65,76 VersandVersand von Deutschland nach USAAnzahl: 1 verfügbar
Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and effi…cacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and theirgene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions.This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
