Mohammad a tabrizi (13 Ergebnisse)
- Hardcover
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Gebundene Ausgabe. Zustand: Sehr gut. Gebraucht - Sehr gut SG - leichte Beschädigungen oder Verschmutzungen, ungelesenes Mängelexemplar, gestempelt - Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the 'unit dose' and 'unit effect' with respect to bot…h beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in 'relevant' animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.
- Hardcover
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Zustand: Hervorragend. Zustand: Hervorragend | Seiten: 260 | Sprache: Englisch | Produktart: Bücher | With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving…therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
Development of Antibody-Based Therapeutics: Translational Considerations
Tabrizi Mohammad A. (EDT)/ Bornstein Gadi G. (EDT)/ Klakamp Scott L. (EDT)
- Hardcover
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Hardcover. Zustand: Very Good. No Jacket. May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less.
- Softcover
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Zustand: New. In.
- Softcover
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Taschenbuch. Zustand: Neu. Development of Antibody-Based Therapeutics | Translational Considerations & Challenges | Mohammad A. Tabrizi (u. a.) | Taschenbuch | viii | Englisch | 2019 | Springer | EAN 9789811344329 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann…[at]springer[dot]com | Anbieter: preigu.
Weitere Bilder- Softcover
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Taschenbuch. Zustand: Neu. Development of Antibody-Based Therapeutics | Translational Considerations | Mohammad A. Tabrizi (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2014 | Springer Nature B.V. | EAN 9781489991133 | Verantwortliche Person für die EU: Springer Nature Customer Service Center GmbH, Europaplatz…3, 69115 Heidelberg, productsafety[at]springernature[dot]com | Anbieter: preigu.
- Softcover
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the 'unit dose' and 'unit effect' with respect to both beneficial and deleterious effects from early stages of development.… The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in 'relevant' animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.
- Hardcover
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Hardcover. Zustand: gut. 2018. Development of Antibody-Based Therapeutics In deutscher Sprache. pages.
Sprache: Englisch
Verlag: Springer Nature Singapore, Springer Nature Singapore, 2019
- Softcover
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, suc…h as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration.This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
Sprache: Englisch
Verlag: Springer Nature Singapore, Springer Nature Singapore, 2018
- Hardcover
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EUR 168,73
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as im…mune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration.This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
- Hardcover
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Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 425 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.
- Softcover
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EUR 194,16
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Zustand: New. Examines important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics Improves the understanding of generation and engineering of human antibodies Discusses st.
Development of Antibody-based Therapeutics: Translational Considerations & Challenges
Tabrizi, Mohammad A. (Editor)/ Bornstein, Gadi G. (Editor)/ Klakamp, Scott L. (Editor)
- Softcover
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Paperback. Zustand: Brand New. 2nd reprint edition. 256 pages. 9.25x6.10x0.59 inches. In Stock.
