Mladen vranic (12 Ergebnisse)

Zustand: New. In English.

Zustand: New. In English.

Zustand: New. In English.

Zustand: New. In English.

Paperback. Zustand: Brand New. 362 pages. 10.10x7.10x0.80 inches. In Stock.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Five years ago, a new system of classification of the various types of diabetes was proposed. This publication provides an inte grated picture of the latest information on the similarities and dissimilarites of two types of diabetes. It contains contributions from morphologists, physiologists, biochemists, immunologists, pathologists, geneticists, clinicians and epidemiologists. In the first section, the basis for the present classification and its limitations are discussed. In addition, there is a discussion of gestational diabetes and heterogeneity of some sub-classes of diabetes. The next section deals with genetics and immunology. The third section discusses abnormalities of insulin secretion and act ion on both the receptor and post . . . receptor levels. The role of gastrointestinal peptides in Type I and Type II diabetes is also considered. In the last section, both types of diabetes are compared with respect to diabetic complications. The closing sec tion summarizes the present status and offers a stimulating view of future development. We hope that this book will be a useful source of information for both researchers and practicing clinicians. M. Vranic G. steiner C. H. Hollenberg v ACKNOWLEDGEMENTS The symposium from which this volume arose (June 28-29, 1984) was organized by the Banting and Best Diabetes Centre, University of Toronto. We would like to express our appreciation to the following sponsors: Ames Educational Institute, Ayerst Laboratories, Becton Dickinson Canada Inc. , Canadian Soft Drink Association, Connaught Laboratories Limited, Connaught Novo Ltd. , Eli Lilly Canada Inc.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, 'New Concepts in the Pathogenesis of NIDDM,' organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia betes research, hoping that this type of interaction may result in new concepts and treat ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ.Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .…

Zustand: New.

Zustand: New. In English.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Regulation of Insulin Secretion.- Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM.- Perturbation of Islet Metabolism and Insulin Release in NIDDM.- Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells.- The ß-Cell Sulfonylurea Receptor.- Insulin, Insulin Receptors and Glucose Transporters.- Regulation of Glucose Transporters and the Na/K-ATPase by Insulin in Skeletal Muscle.- Insulin Receptor: Aspects of Its Structure and function.- The Diabetogenes Concept of NIDDM.- Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptor.- Autoregulation of Glucose Transport: Effects of Glucose on Glucose Transporter Expression and Cellular Location in Muscle.- Insulin Action in NIDDM.- Insulin Resistance and the Pathogenesis of Non-Insulin Dependent Diabetes Mellitus: Cellular and Molecular Mechanisms.- Indirect Effects of Insulin in Regulating Glucose Fluxes.- The Insulin-Antagonistic Effect of the Counterregulatory Hormones - Clinical and Mechanistic Aspects.- On Insulin Action in Vivo: The Single Gateway Hypothesis.- Gluconeogenesis.- Acute Hormonal Regulation of Gluconeogenesis in the Conscious Dog.- Estimating Gluconeogenic Rates in NIDDM.- Glucose Metabolism during Physical Exercise in Patients with Noninsulin-Dependent (Type II) Diabetes.- Substrates and the Regulation of Hepatic Glycogen Metabolism.- Gluconeogenesis in Type 2 Diabetes.- Obesity, Lipoproteins, Atherogenesis, and NIDDM.- Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome.- Cellular and Molecular Factors in Adipose Tissue Growth and Obesity.- Regional Obesity and NIDDM.- Hyperinsulinemia and VLDL Kinetics.- Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM.- Potential Impact of New Concepts In NIDDM on Delivery of Care to Diabetic Populations.- A Paradigm to Link Clinical Research to Clinical Practice: The Challenge in Non-Insulin Dependent Diabetes Mellitus.…

Hardcover. Zustand: Brand New. 332 pages. 10.25x7.00x0.75 inches. In Stock.

Gebunden. Zustand: New. KlappentextTwo dozen papers present theories on the molecular and genetic mechanisms responsible for the development of glucose intolerance in non-insulin-dependent diabetes mellitus. They cover the regulation of insulin secretion insul.