Michael f ochs (22 Ergebnisse)

hardcover. Zustand: Good. Ex- library copy with stamps and stickers.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 360 | Sprache: Englisch | Produktart: Bücher | This volume of Methods in Molecular Biology focuses on techniques to determine the function of a gene. Traditionally, the function of a gene was determined following cloning, which provided its DNA sequence and an ab- ity to modify this sequence. Experiments were performed that looked for p- notypic changes in a cell line or model organism following modifications to the sequence, knocking out of the gene, or enhancing expression of the gene. In the 1990¿s, the growing sequence databases and the BLAST algorithm provided additional power by allowing identification of genes with known function that had similar sequences and potentially similar molecular mechanisms. On the experimental side, methods, such as two-hybrid screening that could directly determine the partners of specific proteins and even the domains of interaction, came into widespread use. With the advent of high-throughput technologies following completion of the human genome project and similar projects in model organisms, the n- ber of genes of interest has expanded and the traditional methods for gene fu- tion analysis cannot achieve the throughput necessary for large-scale exploration. Although computational tools such as BLAST remain a good point of departure, it is often the case that a gene that appears interesting in a hi- throughput experiment shows no obvious similarity to a gene of known fu- tion. In addition, when BLAST does find a similar gene, the process has often only begun.…

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: Used. pp. 360 52:B&W 6.14 x 9.21in or 234 x 156mm (Royal 8vo) Case Laminate on White w/Gloss Lam.

Zustand: New. In English.

Zustand: Used. pp. 360.

Zustand: New. pp. 432 123 Illus. (86 Col.).

Taschenbuch. Zustand: Neu. Biomedical Informatics for Cancer Research | Michael F. Ochs (u. a.) | Taschenbuch | xviii | Englisch | 2014 | Springer | EAN 9781489984517 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Zustand: New. In English.

Zustand: New. In English.

Zustand: New. In English.

Zustand: New. In English.

Taschenbuch. Zustand: Neu. Gene Function Analysis | Michael F Ochs | Taschenbuch | xiv | Englisch | 2010 | Humana Press | EAN 9781617377488 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.…

Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 372 | Sprache: Englisch | Produktart: Bücher | view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.…

Hardcover. Zustand: Brand New. 1st edition. 337 pages. 9.50x6.25x1.00 inches. In Stock.

Zustand: New. Editor(s): Ochs, Michael F. Series: Methods in Molecular Biology. Num Pages: 337 pages, 73 black & white illustrations, 17 black & white tables, biography. BIC Classification: MFN; PSA; PSF; TCB. Category: (P) Professional & Vocational. Dimension: 229 x 152 x 20. Weight in Grams: 551. . 2010. 1st ed. Softcover of orig. ed. 2007. Paperback. . . . . Books ship from the US and Ireland. …

Hardcover. Zustand: Brand New. 1st edition. 354 pages. 9.25x6.00x0.75 inches. In Stock.

Hardcover. Zustand: Brand New. 2nd edition. 416 pages. 10.25x7.25x1.25 inches. In Stock.

Zustand: New. Gene Function Analysis Editor(s): Ochs, Michael. Series: Methods in Molecular Biology. Num Pages: 337 pages, 73 black & white illustrations, 17 black & white tables, biography. BIC Classification: PSAK; PSD. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 234 x 156 x 20. Weight in Grams: 701. . 2007. 2007th Edition. hardcover. . . . . Books ship from the US and Ireland. …

Zustand: New. This book presents computational and experimental techniques for identifying not only the function of an individual gene but also the partners that work with that gene. It provides step-by-step detail essential for reproducible results. Editor(s): Ochs, Michael F. Series: Methods in Molecular Biology. Num Pages: 416 pages, 37 black & white illustrations, 86 colour illustrations, biography. BIC Classification: PSAK. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 24. Weight in Grams: 1000. . 2013. 2nd revised ed. 2014. Hardback. . . . . Books ship from the US and Ireland.…