marek jankowski (4 Ergebnisse)

Zustand: New. Jakubowska, Marta (illustrator). In.

Paperback. Zustand: Brand New. Jakubowska, Marta (illustrator). 92 pages. 9.25x6.00x0.25 inches. In Stock.

Taschenbuch. Zustand: Neu. Jakubowska, Marta (illustrator). Druck auf Anfrage Neuware - Printed after ordering - This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

Taschenbuch. Zustand: Neu. Jakubowska, Marta (illustrator). Interleukin-27: Biological Properties and Clinical Application | Marek Jankowski (u. a.) | Taschenbuch | SpringerBriefs in Immunology | vi | Englisch | 2016 | Springer | EAN 9783319396620 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.