li albert p (23 Ergebnisse)

280 pages Very good condition. Retired library exemplar with usual stamps/ stickers. Reading pages are very clean. --- Sehr guter Zustand. Leseseiten sind sauber und ohne Markierungen. Ausgeschiedenes Bibliotheksexemplar mit entsprechender Kennzeichnung und leichten Lagerspuren. Ansonsten sehr gutes und ordentliches Exemplar. 9780881670837 Sprache: Englisch Gewicht in Gramm: 503 Hardcover, 23.2 x 16.7 x 2.8 cm.

24 cm. original cloth, gilt. 280 pp. ills. references. index. -(slightly bumped, some underlinings in ink, otherwise (very) good). 670g.

pbk. Contents Foreword Preface 1 Overview pharmacokinetic drug drug interactionsAlbert P Li and Malle Jurima Romet 2 Role of cytochrome P450 enzymes in Drug drug interactionsF Peter Guengerish 3 The liver as a target for chemical chemical interactionsJohn Michael Sauer Eric R Stine Lhanoo Gunawardhana Dwayne A Hill and I Glenn Sipes 4 Application of human liver microsomes in metabolism based drug drug interactions in vitro in vivo correlations and the Abbott Laboratories experienceA David Rodrigues and Shekman L Wong 5 Primary hepatocyte cultures as an in Vitro experimental model for the evaluation of pharmacokinetic drug drug interactionsAlbert P Li 6 Liver slices as a model in drug metabolismJames L Ferrero and Klaus Brendel 7 Use of cDNA expressed human cytochrome P450 enzymes to study potential drug drug interactionsCharles L Crespi and Bruce W Penman 8 Pharmacokinetics of drug interactionsGregory L Kedderis 9 Experimental models for evaluating enzyme induction potential of new drug candidates in animals and humans and a strategy for their useThomas N Thompson 10 Metabolic drug drug interactions perspective from FDA medical and clinical pharmacology reviewersJohn Dikran Balian and Atiqur Rahman 11 Drug interactions perspectives of the Canadian drugs directorateMalle Jurima Romet 12 Overview of experimental approaches for study of drug metabolism and drug drug interactionsFrank J Gonzalez Index This volume presents a comprehensive review of drug-drug interactions from the perspectives of academia industry and government regulatory agencies The topics covered include drug metabolism enzymes toxicology in vitro mechanistic approaches and the regulatory perspectives of drug-drug interactions Drug-Drug Interactions Scientific and Regulatory perspectives is intended for  professionals in the pharmaceutical industry in health care and in governmental regulatory agencies who are interested in understanding the mechanisms of drug-drug interactions predicting the interaction potential of new drugs and avoiding clinically significant drug-drug interactions in patients It should also be of interest to students and researchers in the areas of pharmacology toxicology pharmacokinetics and medicine 304 pp.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

Zustand: New. pp. 244 Illus.

493 S., 0849388153 Sprache: Englisch Gewicht in Gramm: 820 Groß 8°, Original-Pappband (Hardcover), sehr gutes und innen sauberes Exemplar, (very good copy),

Zustand: New. xiii 854 8 of lates Illus.

Hardcover. Zustand: Brand New. 1st edition. 244 pages. 10.00x6.50x1.00 inches. In Stock.

Zustand: New. Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. Editor(s): Li, Albert P. Series: Wiley Series in Drug Discovery and Development. Num Pages: 244 pages, Illustrations. BIC Classification: MMG; PNN. Category: (P) Professional & Vocational. Dimension: 235 x 164 x 22. Weight in Grams: 582. . 2007. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

Zustand: New. In.

Zustand: New. In.

Buch. Zustand: Neu. Neuware - Early evaluation of potential drug-drug interactionsAddressing the potential for adverse interactions among coadministered drugs before marketing a new drug can save time, money, and lives. In this reference, distinguished international experts comprehensively review the issues, relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. Focusing on evaluation during the drug discovery process, Drug-Drug Interactions in Pharmaceutical Development:\*Details the major scientific concepts and preclinical experimental approaches\*Covers both clinical and nonclinical aspects\*Discusses in vitro and in vivo methodologies\*Covers genomic approaches\*Addresses U.S., European, and Japanese regulations\*Includes a chapter on herbal drug interactionsCompiling current information into one accessible resource, this is an excellent reference for industrial scientists and regulatory specialists in drug development as well as academic researchers and students in the fields of pharmacology, drug metabolism, and toxicology.

Zustand: New. pp. 352.

Gebunden. Zustand: New. Chuang Lu, PhD, is the Associate Director in the Drug Safety and Disposition Department of Millennium Pharmaceuticals. His current research interests include drug-metabolizing enzymes, drug-drug interaction, and in vitro-in vivo correlation.Albert P. Li, Ph.

Hardcover. Zustand: Brand New. 499 pages. 9.00x6.00x1.25 inches. In Stock.

Zustand: New. This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity. Num Pages: 352 pages. BIC Classification: MJ. Weight in Grams: 666. . 2021. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

Hardcover. Zustand: Brand New. 1st edition. 854 pages. 10.00x6.25x1.75 inches. In Stock.

Buch. Zustand: Neu. Neuware - TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITYExplore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resourcesTransporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development - accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences.Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity.Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as:\* A thorough overview of and introduction to drug metabolism and transporters and drug toxicity\* An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities\* A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity\* A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI\* An examination of transporters and cochlea toxicityPerfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

Zustand: New. This book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both pharmacology and pharmacokinetic aspects of enzyme inhibition. Editor(s): Lu, Chuang; Li, Albert P. Num Pages: 868 pages, Illustrations. BIC Classification: MJ; MMG; PN. Category: (P) Professional & Vocational. Dimension: 244 x 167 x 44. Weight in Grams: 1324. . 2010. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

Buch. Zustand: Neu. Neuware - The science and applied approaches of enzyme inhibition in drug discovery and developmentOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the 'good' inhibitions--desirable pharmacological effects--and 'bad' inhibitions--drug-drug interactions and toxicity. The book discusses:\* The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\* The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug-drug interactions\* The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathwayThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.