Levan n (5 Ergebnisse)
- Softcover
Anbieter: ThriftBooks-Dallas, Dallas, TX, USAThriftBooks-Dallas
Verkäufer/-in kontaktierenVerkäufer/-in mit 5 SternenZustand: Gebraucht - Befriedigend
EUR 8,73
Versand gratisVersand innerhalb von USAAnzahl: 1 verfügbar
Paperback. Zustand: Good. No Jacket. Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.
- Softcover
Anbieter: Better World Books: West, Reno, NV, USABetter World Books: West
Verkäufer/-in kontaktierenVerkäufer/-in mit 5 SternenZustand: Gebraucht - Befriedigend
EUR 10,24
Versand gratisVersand innerhalb von USAAnzahl: 1 verfügbar
Zustand: Good. 3rd Edition. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.
- Softcover
Anbieter: Foggypaws, Sonoma, CA, USAFoggypaws
Verkäufer/-in kontaktierenVerkäufer/-in mit 4 SternenZustand: Gebraucht - Gut
EUR 18,43
EUR 6,84 VersandVersand innerhalb von USAAnzahl: 1 verfügbar
Paperback. Zustand: Very Good. Paperback in very good condition. Highlighting on some inside pages. Other than that, all other inside pages are in great shape. Minor shelf wear to the cover.
Verlag: Optimization Software, Inc, 1983
- Softcover
Anbieter: Anybook.com, Lincoln, Vereinigtes KönigreichAnybook.com
Verkäufer/-in kontaktierenVerkäufer/-in mit 5 SternenZustand: Gebraucht - Ausreichend
EUR 3,01
EUR 15,88 VersandVersand von Vereinigtes Königreich nach USAAnzahl: 1 verfügbar
Zustand: Fair. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. In fair condition, suitable as a study copy. Dust jacket in fair condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,450grams, ISBN:3540909001….
- Softcover
- Erstausgabe
Anbieter: Herman H. J. Lynge & Søn ILAB-ABF, Copenhagen, DänemarkHerman H. J. Lynge & Søn ILAB-ABF
Verkäufer/-in kontaktierenVerkäufer/-in mit 4 SternenZustand: Gebraucht
EUR 7.438,47
Versand gratisVersand von Dänemark nach USAAnzahl: 1 verfügbar
In den WarenkorbLund, 1956. 4to. Minor signs of wear. A fine copy, With signature of "Joh. Holtfreter" to top of p. (1). 6 pp. + 1 plate. First printing, in the very rare off-print - Johannes Holtfreter's copy -, of the revolutionary paper that established for the first time the correct number of chromosomes in man, thus founding modern human c…ytogenetics. The present paper constitutes the most important breakthrough in genetics since Mendel. "The finding that the normal human diploid chromosome number was 46, rather than 48 as had been assumed for many years previously, represents the starting point of modern human cytogenetics, with great importance for future clinical applications in the detection of both constitutional chromosome abnormalities and somatic abnormalities such as those seen in cancers. This discovery, made 50 years ago at the Institute of Genetics of the University of Lund, Sweden, in December 1955 and published early in 1956 in the journal "Hereditas" (Tjio and Levan 1956), is now of historical as well as scientific importance." (Harper). "After 50 years, the paper of Tjio and Levan can be clearly seen as one of the major landmarks of human genetics, opening up the field of human chromosomes and of medical genetics generlly to detailed analysis, as well as fulfilling its original aim of providing a normal reference point for studies of chromosomes in cancer." (Harper).The rediscovery of Mendel's law at the end of the 19th century triggered intense interest in the principles of heredity" ever since that time, chromosome behavior had been studied scientifically, but although a great deal of scientific interest was directed towards learning more about chromosomes themselves, it wasn't until Joe Hin Tjio and Albert Levan's epochal discovery that the correct human chromosome count was established. For half a century it had been accepted that humans normally have 48 chromosomes - only due to Tjio and Levan were we to know that the chromosome number of man is actually 46. "Difficulties in determining the human diploid number arose for a variety of reasons. For one, early experiments that provided evidence for the chromosome theory often used invertebrate species that reproduced in large numbers and had a relatively low number of well-defined chromosomes. Neither of these characteristics, of course, is a common finding in humans. In addition, the human samples initially used for chromosome analysis were derived from fresh testicular tissue in which haploid meiotic cells were often present. Furthermore, what morphology could be deduced suggested that human chromosomes were more complex than those of the model organisms studied earlier. In light of these and other factors, an erroneous estimate by prominent cytologist Theophilus Painter dominated the field for decades, until researchers Joe Hin Tjio and Albert Levan eventually applied new technology to identify the true diploid number of human chromosomes." (O'Connor). As Painter's estimate of 48 chromosomes had been generally accepted from studies over the previous 30 years, study of normal human chromosomes was not an active research field in the mid-1950's. Albert Levan - one of the key figures in cancer cytogenetics -, however, extensively studied the chromosomes of human cancers and realized that it was necessary to be certain of the normal human karyotype. Likewise, Joe Hin Tjio - who then was primarily involved in plant cytogenetics - realized the importance and necessity in establishing the correct number. "In the decades following Painter's work, scientists continued to refine their methods for preparing chromosomes for microscopy. Sectioning of paraffin-embedded preserved tissue was gradually replaced by squash techniques, in which small tissue specimens are placed on a microscope slide and then literally squashed under a cover slip to produce a single layer of cells. This approach gained broad acceptance as it eliminated any need to slice through tissues and reconstruct th.
