Keith l march (6 Ergebnisse)

Zustand: New. In English.

Taschenbuch. Zustand: Neu. Gene Transfer in the Cardiovascular System | Experimental Approaches and Therapeutic Implications | Keith L March | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2012 | Springer Us | EAN 9781461378815 | Verantwortliche Person für die EU: Springer Heidelberg, Tiergartenstr. 17, 69121 Heidelberg, buchhandel-buch[at]springer[dot]com | Anbieter: preigu. …

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled 'Artificial Self-Assembling Systems for Gene Transfer', brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: - size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . - potential tumorigenesis (e. g. retrovirus) - potential for insertional mutagenesis (greater than plasmid based systems) - potential imrnunogenicity (e. g.…

Kartoniert / Broschiert. Zustand: New. The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expr.

Paperback. Zustand: Brand New. reprint edition. 538 pages. 9.25x6.10x1.09 inches. In Stock.

Paperback. Zustand: Brand New. 516 pages. 9.40x6.30x1.40 inches. In Stock.