Jeffrey borenstein (10 Ergebnisse)

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Soft cover. Zustand: Very Good. 2nd Edition. Oversized paperback, second edition, xv + 380 pages, NOT ex-library. Signs of light wear; book is clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. Straight spine. -- This is a technical manual for designing and using Organ-on-a-Chip technology. It focuses on the intersection of microfabrication and cell biology, providing the engineering blueprints needed to create miniature, functional models of human organs. Core Objectives: - Engineering 3D Environments: It explains how to move beyond flat Petri dishes to create 3D micro-environments that mimic the physical and chemical conditions inside the human body; - Disease Modelling: A major focus is the development of specific models for drug toxicity testing and disease progression, particularly for the liver and lung. - Scale-Up for Industry: It addresses the "translation" problem - how to move a delicate microfluidic device from a university lab to a mass-produced industrial tool for pharmaceutical screening. Technical Breakdown: - Micro-scale Physics: The text details how fluids behave at the micron level, focusing on laminar flow, shear stress, and nutrient delivery to living cells. - Biomaterials: It reviews the materials used to build these systems (such as PDMS and other polymers) and how to ensure they are biocompatible so they do not kill the cells they are meant to house. - Multi-Organ Systems: The book explores "Body-on-a-Chip" concepts, where multiple organ models are connected by micro-channels to simulate how a drug might move from the gut to the liver and eventually the bloodstream. It serves as a bridge for engineers who understand fluid dynamics but need to learn cell biology, and for biologists who understand disease but need the hardware to simulate it accurately without using animal models.…

Zustand: New. pp. xviii + 627 Illus.

Gebunden. Zustand: New. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell c.

Paperback. Zustand: Brand New. 452 pages. 9.25x7.50x1.02 inches. In Stock.

Hardcover. Zustand: Brand New. 1st edition. 452 pages. 9.75x8.00x1.25 inches. In Stock.

Zustand: As New. Unread book in perfect condition.

Zustand: New. 2012. Illustrated. hardcover. . . . . . Books ship from the US and Ireland.

Zustand: New. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and m.

Taschenbuch. Zustand: Neu. Neuware - Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances.…