Jackman ann l (24 Ergebnisse)

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1250grams, ISBN:9780896035966. …

Zustand: New. In English.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: Used. pp. 272 69 Illus. (22 Col.).

Zustand: Used. pp. 272.

Zustand: New.

Gebunden. Zustand: New.

Zustand: New. In English.

Zustand: New. In English.

Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 268 | Sprache: Englisch | Produktart: Bücher | Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.…

Zustand: Used. pp. 472.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.…

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.…

Zustand: Used. pp. 472.

Taschenbuch. Zustand: Neu. Targeted Drug Strategies for Cancer and Inflammation | Christopher P. Leamon (u. a.) | Taschenbuch | xi | Englisch | 2014 | Springer | EAN 9781489988867 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Hardcover. Zustand: Brand New. 1st edition. 221 pages. 9.50x6.25x0.50 inches. In Stock.

Taschenbuch. Zustand: Neu. Antifolate Drugs in Cancer Therapy | Ann L. Jackman | Taschenbuch | Cancer Drug Discovery and Development | x | Englisch | 2013 | Humana | EAN 9781475745214 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Zustand: New. In English.

Zustand: New. In English.

Paperback. Zustand: Brand New. reprint edition. 466 pages. 10.00x7.00x1.11 inches. In Stock.

Hardcover. Zustand: Brand New. 1st edition. 456 pages. 10.25x7.50x1.25 inches. In Stock.

Zustand: New. Editor(s): Jackman, Ann L. Series: Cancer Drug Discovery and Development. Num Pages: 456 pages, 13 black & white illustrations, biography. BIC Classification: MQP. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 24. Weight in Grams: 891. . 2013. Softcover reprint of the original 1st ed. 1999. Paperback. . . . . Books ship from the US and Ireland.…

Zustand: New. A collection of reviews which comprehensively examines the status of novel antifolates, an important class of anticancer drugs. This book discusses the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors, 5-fluorouracil, and a new generation of antifolates. Editor(s): Jackman, Ann L. Series: Cancer Drug Discovery and Development. Num Pages: 456 pages, 13 black & white illustrations, biography. BIC Classification: MJCL2; MMG. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 254 x 178 x 25. Weight in Grams: 1073. . 1999. Hardback. . . . . Books ship from the US and Ireland.…