Jaakko saraste (5 Ergebnisse)

rough endoplasmic reticulum and the Golgi complex(S.A.Cell Biol.Vol.3)1992.S.343-355.Quart.m.zahlr.Abb.br.-2) -Sonderabdruck-.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The second volume (of two) of The Golgi Network book, explores the role of this organelle in a plethora of cellular functions, complementing perfectly the first volume with the most recent discoveries.In this part, the description of the machinery involved in trafficking explores the interaction of Golgi with different organelles such as ER and the vesicular system, as well as protein complexes in charge to execute these tasks, like COG, and GARP, among others. An important part of this volume studies in depth the sorting mechanisms that occur in different areas of the cell and their most important components, a part of this volume includes the effects of Golgi on glycosylation systems, and in a special section, we can learn about new Golgi-associated functions such as the nucleation of microtubules and their effect on signaling in the immune system.The last part of this volume explores the association of Golgi and its malfunction with different diseases, focusing mainly on cancer and neurodegeneration.In this fashion, this volume is a valuable resource for professionals working on different fields of Golgi research and is strongly suggested to those involved in translational science.…

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The Golgi apparatus was discovered by Camillo Golgi in 1898. Today, more than 125 years later, the Golgi apparatus is still a key object of active biochemical and cell biological research. The role of this organelle as a glycosylation factory has been well recognized while its function as a central station in protein sorting in membrane trafficking has raised many disputes during the past decades.Morphologically, the beautiful cisternal stacks are often considered a typical structure of the Golgi, but looking across a variety of eukaryotic species, large variations in Golgi organization become apparent. Despite the long history of Golgi research, there still are many unanswered questions. How are Golgi residents and passing cargo proteins and lipids sorted from each other and find their correct transport routes and final destinations What are the carriers or mechanisms mediating communication between cisternae vesicles, tubules, or close membrane contacts How is the compositional polarity of the organelle between the cis- and trans-sides established and maintained What are the contributions of lipids in Golgi organization and function Why do the cisternal Golgi stacks form ribbon structures in vertebrates What are the precise roles of next-door neighbors of the Golgi the intermediate compartment (ERGIC/IC) at the cis-face and the trans-Golgi network (TGN) at the trans-face in its maintenance and function To address these questions, many new technologies have been developed, leading to exciting discoveries. For example, state-of-the-art microscopic methods, such as high-speed and high-resolution live imaging and correlative light and electron microscopy are regarded as very promising approaches and are therefore undergoing continuous development.This first volume of two presents the latest knowledge about the Golgi Organization and Dynamics covering different kingdoms from Fungi to Animals, put together by leading experts in the field contributing individual chapters to this book, which represents an exceptional collection of current concepts about the Golgi and its neighboring organelles. As such it is a valuable resource for both researchers and students.…

Hardcover. Zustand: Brand New. 350 pages. 9.25x6.10x9.21 inches. In Stock.

Hardcover. Zustand: Brand New. 492 pages. 6.14x1.06x9.21 inches. In Stock.