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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Volume 5 of the series 'Advances in Research on Neurodegeneration' is concerned with themes which are currently the focus of intensive research, and in which advances in our understanding of the pathological mechanisms un derlying neurodegenerative diseases are expected in the near future. The first section contains five reviews devoted to the various neuroimaging technolo gies. The discussion is concerned with the question of whether neuroimaging techniques make it possible to follow the process of degeneration as it occurs, and which methods offer the required sensitivity and quantifiability for this purpose. However, the question needs to be examined of whether, given the physical and chemical limitations of these techniques, even under optimal conditions, anatomical resolution can be improved to the extent that neuro degenerative diseases can be diagnosed earlier than currently possible and a confident diagnosis made. The possibilities of using neuroimaging techniques to provide information regarding the effects of neuroprotective or neuroregen erative therapeutic strategies, and for correlating the results of neuropsycho logical research with imaging data are also discussed. The second section is concerned with the significance of endogenous or exogenous neurotoxins as triggers for neurodegenerative processes that may lead to Parkinsonism. Vulnerability factors, which include such factors as nerve ending sensitivity, the synergistic effects of drugs and the various mechanisms underlying different toxins are discussed.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - InhaltsangabeThe morphology of LRH and oxytocin neurons.- Anatomical relationships between estrogen target sites and peptidergic-aminergic neurons: multiple activation of heterogeneous systems (MAHS).- Estradiol concentration in dopamine- -hydroxylase containing neurons of lower brain stem demonstrated by combined autoradiography and immunohistochemistry.- Intracellular actions of gonadal steroids.- Neural estrogen receptors in the life cycle of the albino rat.- Effects of sex hormone metabolites on the secretion of gonadotropins.- Estrogen effects on LH-RH degrading brain and pituitary enzymes.- Mediators of feedback message: estrogens and/or catechol-estrogens .- Effects of oestradiol-17 and 2-hydroxy-oestradiol-17 on LH concentration in plasma and COMT activities in hypothalamic nuclei of rats.- Gonadal steroids and brain monoamines: how do they interact .- Steroid effects on hypothalamic-gonadotropin interactions.- Differences in negative and positive feedback of gonadal steroids on release of gonadotropins and prolactin in young and old rats.- Gonadal steroids and the control of gonadal function in seasonally breeding species.- Influence of estradiol and other gonadal steroids on central effects of Iisuride and comparable ergot derivatives.- Regulation of prolactin secretion at the pituitary level.- The role of the central nervous system in the control of the menstrual cycle of the rhesus monkey.- The limbic system and female sexual maturation.- Estrogen facilitation of lordosis behavior in the female rat.- Sex hormone dependent brain differentiation and sexual behavior.- Critical evaluation of the current concept of brain differentiation - relevance for the primate brain.- Physiology of somatosensory and estrogenic control over the lordosis reflex.- Neural structures essential for the control of prolactin surges in the female rat.- Electrophysiological and morphological properties of E2-responsive neurons.- Effects of gonadal steroids on EEG and performance in the human.- Concluding remarks on gonadal steroids and brain function.- Poster Presentations.- Effect of low doses of continuously administered catecholestrogens on peripheral and central target organs.- LHRH changes concomitant with catecholamine turnover rates in discrete hypothalamic nuclei and median eminence: effects of ovariectomy, estradiol (E2) and progesterone (P4) therapy and phenobarbital treatment.- Mechanisms involved in selective FSH release during estrus in the cyclic rat.- A dual effect of dopamine on both release and degradation of LH-RH by hypothalamic synaptosomes.- Serotonin: possible function in diurnal regulation of LH and prolactin release.- Effect of ACTH-induced testosterone release on the secretion of pituitary gonadotrophin and prolactin release in male pigs.- Influence of 4-hydroxyestradiol, ethyny lestradiol, estradiol and danazol on the LH-RH induced gonadotrophin release in ovariectomized rats.- Dehydrotestosterone and estradiol regulating the activity of 3 -hydroxysteroid dehydrogenase in the pituitary gland of the rat: action of antiestrogens.- Circulating steroid levels and brain neurotransmitter concentrations in the midterm human fetus.- Comparison of estrogenic versus anti-estrogenic influences on postnatal defeminization and masculinization of the rat brain.- Effect of estradiol on catecholamine turnover and on the activities of catecholamine degrading enzymes in brain areas of ovariectomized rats.- Chinning in male Tupai Belangeri and its hormonal modification in short- and long-term castrates.- Interactions of catecholoestrogens with oestrogen receptors of rat pituitary and hypothalamus.- Direct effect of 2-hydroxy-oestradiol-17 on the hypothalamus and the control of LH secretion.- Effects of 2-hydroxyoestradiol and dopamine on the release of prolactin and luteinising hormone from rat pituitary glands in vitro.- Involvement of GABA in negative feedback action of estradiol.- The role of substance P, neurotensin and arginine vasotocin i.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Neurodegeneration is one of the most important subjects of the investigation now and in the coming 21st century. Alzheimer's disease is the leading cause of dementia in the elderly people and Parkinson's disease is one of the major neurologic disorders with the prevalence between 1 and 2/1 000 population in advanced countries. Many others are suffering from intractable neurodegener ative disorders such as amyotrophic lateral sclerosis, Huntington's disease, or spinocerebellar degeneration. No truly effective treatment is available for any of these neurodegenerative disorders except for Parkinson's disease; even in Parkinson's disease, still it is impossible to slow down the disease process with the currently available treatment. It is urgently needed to develop new effective technique to halt or slow down the disease process in each of those disorders. Recent advance in the molecular biological and molecular genetic technique has brought us great progress in the understanding of etiology and pathogenesis of these disorders, but still it is not known how neurons are going to die in these disorders. To explore the question, mutual cooperation and exchange of ideas between basic scientists and clinical peoples are of utmost importance.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - We organized the Seventh International Winter Conference on Neurodegeneration and Neuroinflammation in a small town of Karuizawa in Nagano Prefecture in Japan on January 20 to 22, 1999. Karuizawa is a nice summer as well as winter resort close to the place for winter Olympic game in the year of 1998. Over 40 scientists gathered together and made hot discussion. Neurodegeneration and neuroinflammation are two major and important neurologic disorders, in which satisfactory neuroprotective and neurorestorative treatment is not available yet. For this purpose, understanding of molecular mechanisms of neuronal cell death in these two disorders is imperative. Recently, pathologic processes common to these two groups of disorders have been identified such as the involvement of inflammatory changes, microglia, cytokines, and apoptosis. We intended to involve scientists working in these two major fields together to participate in hot and fruitful discussion for the understanding of neuronal death and for developing newer methods of treatment. The science is progressing so rapidly today and we are working in a very narrow specialized area. Sometimes, we are ignorant about important discoveries in other fields. This conference was a nice opportunity for scien tists working different areas to meet together and to exchange their experi ence. This volume is the proceedings of this Winter Conference.

Taschenbuch. Zustand: Neu. Gonadal Steroids and Brain Function | IUPS-Satellite-Symposium Berlin, July 10-11, 1980 | R. Horowski (u. a.) | Taschenbuch | xiv | Englisch | 1981 | Springer-Verlag GmbH | EAN 9783540106067 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Advances in Research on Neurodegeneration | 3 & 4 | Y. Mizuno (u. a.) | Taschenbuch | viii | Englisch | 1997 | Springer | EAN 9783211829349 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - In 1991, a small annual meeting named 'International Winter Conference on Neurodegeneration (lWCN)' was established; the aim of this meeting is to review the neurodegenerative disorders and to attempt to explore how progress might be made in this field, as the neurodegenerative disorders have been emerging to be one of the major causes of morbidity and mortality in modern societies. The first meeting took place in Seefeld, Austria, in February 1992; the topics for the first IWCN were chosen to provide a broad foundation of clinical science, which included the problem of aging, classification of neurodegenerative disorders and of Alzheimer's dis natural history, pathology, and clinical neurology ease, Parkinson's disease, and amyotrophic lateral sclerosis. The fundamental pathology underlying these neurodegenerative disorders is neuronal cell death. For the understanding of pathophysiol ogy and the development of neuroprotective treatment for these dis orders, elucidation of the mechanism of neuronal cell death at the cellular and molecular level is essential. With this concept in mind, the second IWCN was held in Whistler Village in Canada in January 1993. Funding was generously provided by Schering AG, Berlin, and for the excellent organization we have to thank Ms. Ingeborg Runge.

Taschenbuch. Zustand: Neu. Advances in Research on Neurodegeneration | Volume 5 | P. Riederer (u. a.) | Taschenbuch | viii | Englisch | 1997 | Springer | EAN 9783211828984 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.