Hoffstaedter felix (1 Ergebnisse)

Lex. 8° (25-30 cm), kart. o. A. Internally vs. externally triggered movements in patients with major depression. Zweisprachig (Englisch/Deutsch), eigentl. Dissert. in Englisch, Bewertung, zahlreiche Textmarkierungen mit Bleistift. --- Background: Psychomotor retardation is a prominent clinical feature of major depression. While several studies investigated these deficits, differences between internally and externally triggered response selection and initiation are less well understood. In the current study, we delineate internally vs. externally driven response selection and initiation in depression and their relation to basic psychomotor functioning. Methods: 20 inpatients diagnosed with a (unipolar) major depression and 20 closely matched healthy controls performed a computerized motor paradigm assessing differences between internally and externally cued movements. Psychomotor performance and basic memory functions were assessed using a neuropsychological test-battery. To examine within group homogeneity a multivariate clustering approach was applied. Results: Patients featured a global slowing of internally and externally cued response selection compared to controls, as well as impairments in basic psychomotor functioning. Yet, basic motor speed was preserved. Furthermore, patients were more severely impaired when movements involved internal response selection. The data-driven clustering revealed two patient subgroups, which both showed psychomotor disturbances, while only one featured slowing of response selection. Sprache: Deutsch Gewicht in Gramm: 250.…