Gregor anderluh (15 Ergebnisse)
Sprache: Englisch
Verlag: Springer 2016
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Sprache: Englisch
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Serie: Subcellular Biochemistry, Buch 40 von 54. Buch 40 von 54 - Subcellular Biochemistry
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Verlag: Springer 2016
Serie: Subcellular Biochemistry, Buch 40 von 54. Buch 40 von 54 - Subcellular Biochemistry
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Taschenbuch. Zustand: Neu. MACPF/CDC Proteins - Agents of Defence, Attack and Invasion | Gregor Anderluh (u. a.) | Taschenbuch | Subcellular Biochemistry | xi | Englisch | 2016 | Springer | EAN 9789402403398 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]sp…ringer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer, Springer 2016
Serie: Subcellular Biochemistry, Buch 40 von 54. Buch 40 von 54 - Subcellular Biochemistry
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein… super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
Sprache: Englisch
Verlag: Springer, Springer 2014
Serie: Subcellular Biochemistry, Buch 40 von 54. Buch 40 von 54 - Subcellular Biochemistry
- Hardcover
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super…family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
Sprache: Englisch
Verlag: Springer Verlag 2014
Serie: Subcellular Biochemistry, Buch 40 von 54. Buch 40 von 54 - Subcellular Biochemistry
- Hardcover
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Taschenbuch. Zustand: Neu. Proteins | Membrane Binding and Pore Formation | Gregor Anderluh (u. a.) | Taschenbuch | xxiv | Englisch | 2016 | Springer | EAN 9781493940981 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer Verlag 2016
Serie: Subcellular Biochemistry, Buch 40 von 54. Buch 40 von 54 - Subcellular Biochemistry
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Zustand: New. Novel structures and biophysical studies on proteinsIncludes a comparison of the properties of membrane channels formed by amyloid proteins and pore forming toxinsGives comprehensive overview of what we know about proteins and highlights their general struc.
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of sever…al steps; proteins need to attach to the lipid membrane, possibly aggregate in the plane of the membrane and finally form a pore by inserting part of the polypeptide chain across the lipid bilayer. Structural information about toxins at each stage is indispensible for the biochemical and molecular biological studies that aim to - derstand how pores are formed at the molecular level. There are currently only two Staphylococcus aureus and hemolysin E from Escherichia coli. Therefore, what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane bi- ing and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.
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Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.
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Buch. Zustand: Neu. Neuware - Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps; proteins need to attach to the lipid mem…brane, possibly aggregate in the plane of the membrane and finally form a pore by inserting part of the polypeptide chain across the lipid bilayer. Structural information about toxins at each stage is indispensible for the biochemical and molecular biological studies that aim to - derstand how pores are formed at the molecular level. There are currently only two Staphylococcus aureus and hemolysin E from Escherichia coli. Therefore, what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane bi- ing and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.
