Gerhard heinemeyer (7 Ergebnisse)

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book closes a current gap by providing the scientific basis for consumer exposure assessment in the context of regulatory risk assessment. Risk is defined as the likelihood of an event occurring and the severity of its effects. The margin between the dose that leads to toxic effects and the actual dose of a chemical is identified by estimating population exposure. The objective of this book is to provide an introduction into the scientific principles of consumer exposure assessment, and to describe the methods used to estimate doses of chemicals, the statistics applied and computer tools needed. This is presented through the backgrounds of the special fields in exposure analysis, such as exposure via food and by the use of consumer products, toys, clothing and other items. As a general concept, human exposure is also understood to include exposure via the environment and from the work setting. In this context, the specific features of consumer exposure are pointed out and put into the context of regulation, in particular food safety, chemicals safety (REACh) and consumer product safety.The book is structured into three parts: The first part deals with the general concepts of consumer exposure as part of the overall risk analysis framework of risk characterization, risk assessment and risk communication. It describes the three basic features of exposure assessment (i) the exposure scenario (ii) the exposure model and (iii) the exposure parameters, addressing external and internal exposure. Also, the statistical presentation of data to characterize populations, in connection with variability, uncertainty and quality of information and the presentation of exposure evaluation results is described. The second part deals with the specific issues of exposure assessment, exposure via food consumption, exposure from use of consumer products, household products, toys, cosmetic products, textiles, pesticides and others. This part also covers methods for acquisition of data for exposure estimations, including the relevant information from regulations needed to perform an accurate exposure assessment. The third part portrays a prospect for further needs in the development and improvement of consumer exposure assessment, as well as international activities and descriptions of the work of institutions that are involved in exposure assessment on the regulatory and scientific level. And conversely, it creates the rationale for the exposure assessment details necessary to satisfy regulatory needs such as derivation of upper limits and risk management issues.…

Hardcover. Zustand: Brand New. 620 pages. 9.25x6.10x1.57 inches. In Stock.

Zustand: New.

Buch. Zustand: Gut. 192 Seiten. 190 mm × 120 mm SB3634 Sprache: Deutsch Gewicht in Gramm: 293.

Broschiert. Zustand: Gut. 191 Seiten; Der Erhaltungszustand des hier angebotenen Werks ist trotz seiner Bibliotheksnutzung sehr sauber und kann entsprechende Merkmale aufweisen (Rückenschild, Instituts-Stempel.). Sprache: Deutsch Gewicht in Gramm: 445.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Intensivpatienten sind durch das Versagen von Vitalfunktionen bedroht und benötigen neben einer apparativen auch eine intensive medikamentöse Behandlung. Die durch die Anwendung eingreifender und hochdosierter Arzneimittel auftretenden Interaktionen, also Antagonismus, Synergismus, gegenseitige Induktion oder Hemmung des Metabolismus, wechselseitige Beeinflussung der Eiweißbindung und der Ausscheidung, sind nicht ausreichend bekannt. Ohne Berücksichtigung dieser Aspekte ist jedoch eine effektive Therapie des intensivmedizinischen Krankheitsbildes nicht möglich. Eine zusammenfassende Darstellung dieser Problematik der modernen Intensivtherapie existierte bisher nicht. In diesem Buch stellen Intensivmediziner und klinische Pharmakologen in ihren Beiträgen die organbezogenen, aber auch arzneimittelbedingten Besonderheiten bei Patienten, die einer Intensivtherapie unterliegen, dar.…

Paperback. Zustand: Brand New. 203 pages. German language. 9.25x6.10x0.49 inches. In Stock.