Florey howard (6 Ergebnisse)

xxii+314pp. 8vo. Original boards in dustwrapper, a very good copy. First edition.

247 s. Några illustrationer. Häftad.

Hardcover. Zustand: Very Good. Zustand des Schutzumschlags: Very Good. First Edition. Hardcover, first edition, with unclipped dust jacket. Includes many illustrations, some in colour. Shelf and edgewear to jacket, including a couple of small tears along upper edges and foxing to spine. Boards lightly bumped at lower leading corners and lightly worn along lower edges. Page block faintly foxed and faintly marked. Text and illustrations are all clean and unmarked, binding is tight. AD. Used.…

Quer-32mo. 1 p. Für die Entdeckung des Antibiotikums Penicillin und seiner Heilwirkung bei verschiedenen Infektionskrankheiten erhielten er, Alexander Fleming und Ernst Boris Chain 1945 gemeinsam den Nobelpreis für Medizin.

A culture vessel used for the production of penicillin, from the collection of the vessel's designer, Norman Heatley. It was used by Howard Florey's research team, who pioneered the drug's clinical use. It is offered with Heatley's collection of offprints by Florey, as well as the papers that announced their discovery: "Penicillin as a Chemotherapeutic Agent" (1940) and "Further Observations on Penicillin" (1941). Although penicillin was discovered in 1928 by Alexander Fleming, it "might well have become an obscure scientific curiosity but for the work of Chain and Florey" (PMM). It was not until 1938, when Florey (1898-1968) and his team at the University of Oxford began working on it, that its therapeutic potential was fully realized. However, a major challenge was producing enough of the drug to treat an adult patient. This problem was solved by Heatley (1911-2004), a "genius for improvisation and invention", who developed the back-extraction technique, enabling penicillin to be efficiently purified in bulk (ODNB). The next obstacle was producing sufficient culture vessels for the new technique during wartime. With metal in short supply and glass prohibitively expensive, the team repurposed domestic items such as baking trays and bedpans from the Radcliffe Infirmary. The bedpans proved particularly effective, inspiring Heatley to design his own version. Produced by James MacIntyre & Co. in Burslem, Staffordshire, in 1940, the vessels were glazed on the inside to be watertight, unglazed on the outside to prevent slippage, and stackable to save space during fermentation. "This unassuming object made it possible for the first clinical trials of penicillin to take place" (BBC/British Museum). In 1941, Florey and Heatley travelled to the US with the evidence from these trials to convince American pharmaceutical companies to undertake mass production of the drug. By 1943, penicillin was in use, "saving hundreds of thousands of lives during World War II" (Norman). Florey received the Nobel Prize in 1945, along with Fleming and Ernst Chain. Although Heatley was not awarded the prize (which limits recipients to three), he received an honorary doctorate of medicine from Oxford in 1990, the first time a non-physician received the award. The crucial role that each individual played in turning penicillin into a usable drug was famously summarized by Henry Harris, Florey's successor as head of pathology at Oxford: "Without Fleming, no Florey or Chain. Without Chain, no Florey. Without Florey, no Heatley. Without Heatley, no penicillin". In 1994, Heatley gifted the vessel and offprints to his neighbour, David Cranston, the author of Penicillin and the Legacy of Norman Heatley (2016). A signed copy is included with the collection, along with related ephemera such as an autograph letter from Heatley discussing the offprint collection and the order of service for Heatley's funeral. The offprints are a representative selection of Florey's wide research interests throughout his career. They include his paper on the antimicrobial enzyme lysozyme - the study of which sparked his interest in penicillin - and his post-penicillin work on antibiotics, particularly against tuberculosis. A copy of the Royal Society's Florey bibliography, annotated to show the contents of this collection, is available upon request. Similar examples of Heatley's culture vessel have appeared at auction twice in the last 20 years: Christie's 2004 and Willingham 2022. Garrison-Morton 1934; Norman 437; Printing and the Mind of Man 420b: all "Penicillin as a Chemotherapeutic Agent". "Penicillin culture vessell", A History of the World, BBC & British Museum. Together, 83 items, comprising ceramic culture vessel, 77 offprints, and 5 ephemeral pieces, housed in 2 custom red cloth boxes. Vessel soiled from use, spout joint sometime repaired with glue, small chip to rim: in very good condition. Tape repair to "Penicillin as a chemotherapeutic agent" affecting text, else offprints in fine or near-fine condition.…

Photo v. Carl Byoir and Associates, New York, o.J. (ca.1950), 11,5 x 7,8 cm; rückseitig Montagespuren. Sir Howard Walter Florey (1898-1968) erhielt den Nobelpreis für Physiologie und Medizin 1945 "Für die Entdeckung des Penizillins und seiner Heilwirkung bei verschiedenen Infektionskrankheiten" gemeinsam mit Ernst Boris Chain und Sir Alexander Fleming. …