Florey al (5 Ergebnisse)

Paperback. Zustand: Very Good.

Zustand: Fair. Volume 16. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1300grams, ISBN:012260816X.…

Zustand: New. In English.

Buch. Zustand: Neu. Neuware - This book marks the 50th anniversary of the foundation of the International Epidemiological Association (IEA). It is a unique compendium by the world's leading epidemiologists of how the field has developed, and how it can be (and has been) applied to the control of common conditions and threats to public health. Five distinct sections guide the reader through the wealth of material: Gives an historical account of the concepts and ideas, and current importance of epidemiology to global health issues and to organisations such as the WHO. Illustrates the advances and contributions to epidemiologic knowledge and the control of disease in specific areas such as cancer, cardiovascular disease, respiratory disease, tuberculosis, maternal and child health, non-biologic disorders such as war and disasters, and new infectious diseases. Outlines the use of epidemiology in areas such as public health, health services, occupational and environmental medicine, social epidemiology and nutrition. Discusses methodological developments such as statistics, information sources, investigation of disease outbreaks and clinical epidemiology. Looks at how the subject has developed internationally, with perspectives on regions such as the Americas, Poland, Spain, Eastern Mediterranean, New Zealand, China, Thailand and Japan.This remarkable insight into how epidemiology has developed is essential reading for both existing and aspiring epidemiologists.…

London, The Lancet Limited, 1940. Royal8vo. Bound in contemporary full black cloth with gilt lettering to spine. In "The Lancet", Vol. 2, 1940. A fine and clean copy. Pp. 226-228. [Entire volume: XX, 830 pp.]. First printing of this seminal paper within microbiology and medicine. Alexander Flemming had in the 20ies discovered penicillin but it was not until Chain and Florey's groundbreaking research, published in the present paper, that the true remarkable features of penicillin - that it was probably the most effective chemotherapeutic drug known - became know and usable on a practical level. Flemming, Chain and Florey received the Nobel Prize in Medicine in 1945 "for the discovery of penicillin and its curative effect in various infectious diseases"."He [Flemming] was unsuccessful, however, due to his limited knowledge of chemistry, and the "mold juice" remained of limited use until 1940-41, when Ernst Boris Chain and Howard W. Florey, using Flemming's original culture, successfully prepared a pure and stable penicillin extract and demonstrated its usefulness in treating human bacterial infection. Within three years the United States government, in collaboration with the pharmaceutical industry, was producing penicillin on a large scale, with the result that many thousand lives were saved during World War II." (Grolier, One Hundred Books Famous in Medicine)."In the late 1930's, Florey and Chain began their investigation of this mold broth filtrate from Penicillium notatum as part of their general interest in systemic antibacterial agents. Fleming had isolated penicillin in 1928. He found it was a promising external antiseptic against some pathogenic bacteria, but its chemical instability (among other reasons) soon led him to abandon penicillin as a therapeutic agent.By May 1940 Chain had produced enough penicillin for Florey to conduct tests on mice infected with deadly hemolytic streptococci. These early tests yielded very promising results, Chain, in collaboration with Edward Abraham, spent the rest of the year improving the extraction and purification of penicillin for clinical tests, which began early in 1941.Serious problems with the fermentation production of penicillin led the British and American governments, by early 1944. to coordinate hundreds of scientists for the development of a commercially feasible synthesis of penicillin. Chain and his collaborators at Oxford, however, had shed much light on the chemistry of the drug by this time. By October 1943, they proposed what turned out to be the correct structure of penicillin. They established a fundamental understanding of the chemistry of penicillin. This aided fermentation work on the drug in the 1940's and served as the foundation for the development of semisynthetic penicillins from the mid 1950's on.".…