erik clercq (32 Ergebnisse)

Softcover. Zustand: As New. Proc presne, chemie a medicina? Autor teto knihy, prof. Erik De Clercq, vesvych prednaskach predstavuje nadherny svet na pomezi (bio)chemie a modernimediciny. Zduraznil napriklad biosyntezu nukleotidu, porfyrinu, hemu,hemoglobinu, cholesterolu, zlucovych kyselin, CO, NO, roli karboxylovychkyselin, mocoviny a dalsich cyklu, patologii diabetu, dny a dalsichmetabolickych onemocneni, roli enzymu, hormonu, vitaminu, antibiotik aantivirotik. Cilem celeho pojednani je okouzlit ctenare bez ohledu na vek cipuvod krasou (bio)chemie pri dobyvani lidskeho zdravi. Why precisely,chemistry and medicine? Author of this book, Prof. Erik De Clercq, in hislectures presents a wonderful world on the border of (bio)chemistry and modernmedicine. He has highlighted, for instance, the biosynthesis of nucleotides,porphyrins, heme, hemoglobine, cholesterol, bile acids, CO, NO, the role ofthe carboxylic acids, urea and other cycles, the pathology of diabetes, goutand other metabolic diseases, the role of enzymes, hormones, vitamins,antibiotics and antivirals. The aim of the whole treatise is to enchant thereaders, whatever their age or background, with the beauty of (bio)chemistryat the conquest of human health.

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,800grams, ISBN:9783764366001.

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,950grams, ISBN:0306416182.

2004th ed. 15 x 23 cm. 254 pages. HC Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Sprache: Englisch.

Hardcover. Zustand: Wie neu. XI, 243 S.; Ill. Like new. Shrink wrapped. Sprache: Englisch Gewicht in Gramm: 855.

Paperback. Zustand: Brand New. reprint edition. 322 pages. 9.61x6.69x0.73 inches. In Stock.

Hardcover. Slight stain to lower RH edges, o/wise good condition in dj. Part of the NATO ASI series, Series A: Life Sciences Vol. 26. x, 459pp. ISBN 0306403021. 11436.

Hardcover. Zustand: Très bon. Ancien livre de bibliothèque avec équipements. Edition 2011. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 2011. Ammareal gives back up to 15% of this item's net price to charity organizations.

Hardcover. Zustand: Très bon. Ancien livre de bibliothèque avec équipements. Edition 1995. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1995. Ammareal gives back up to 15% of this item's net price to charity organizations.

Hardcover. Good condition. No dj. Part of the NATO ASI series, Series A: Life Sciences Vol. 26. x, 459pp. ISBN 0306403021. 11436.

Taschenbuch. Zustand: Neu. Antiviral Drug Development | A Multidisciplinary Approach | Erik De Clercq (u. a.) | Taschenbuch | viii | Englisch | 2012 | Springer | EAN 9781468472776 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Targets for the Design of Antiviral Agents | Erik De Clercq | Taschenbuch | xii | Englisch | 2013 | Humana | EAN 9781468447118 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Antiviral Chemotherapy: An Introduction and Reasons for the Slow Progress, Particularly towards Rational Design.- Design of Nucleoside Analogs as Potential Antiviral Agents.- Design of Anti-Viral Agents other than Nucleoside Analogues.- Antivirals for High Hazards Viruses.- Human Retroviruses and Anti-Viral Therapies.- Epstein-Barr Virus.- Molecular Targets for Selective Antiviral Chemotherapy.- Inhibition of S-Adenosylmethionine-Dependent Transmethylation as an Approach to the Development of Antiviral Agents.- Assay Systems: Testing of Antiviral Drugs in Cell Culture (in vitro).- Animal Models as Assay Systems for the Development of Antivirals.- Experimental Aspects of Antiviral Pharmacology.- Virus Drug Resistance.- Interferon as an Antiviral Agent.- Risk-Benefit Analysis in Drug Research.- Safety Assessment of Antiviral Drugs.- Antiviral Agents: A New Beginning.- Participants.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This pUblication contains the Review Lectures presented at a joint NATO Advanced Study Institute and FEES Advanced Study Course held at Les Arcs, Bourg-8aint-Maurice, France, from the 19th June - 2nd July 1983. The Course, entitled 'Targets for the Design of Antiviral Agents' was in some ways a sequel to the NATO-FEES Course held at SOGESTA (near Urbino), Italy from the 7th - 18th May 1979 and published as volume A26 in this series. During the subsequent four years, we have witnessed the first of the 'new generation' of antiviral compounds, which are more efficacious and less toxic than the 'classical' antiviral drugs, reach the clinic and we felt that it w~s the right time to assess the future prospects of this verY important and exciting field. The vast majority of the drugs developed recently have proved active against various members of the herpesvirus family and elsewhere in this publication we learn that the cure for only rather few viral diseases, such as the common cold, influenza and herpes, promises the return on investment required by the pharmaceutical industry. However, the aim of this Course was for eminent virologists to identify possible targets among the various virus classes against which the chemists could then design suitable therapeutic agents. Recent advances with antiherpesvirus drugs have shown that a far greater selectivity and therapeutic index can be obtained than was previously thought to be possible.

Zustand: New. pp. 260 Illus.

Taschenbuch. Zustand: Neu. Combination Therapy of AIDS | Anne-Mieke Vandamme (u. a.) | Taschenbuch | xi | Englisch | 2012 | Birkhäuser | EAN 9783034896047 | Verantwortliche Person für die EU: Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Buch. Zustand: Neu. Neuware -HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 260 pp. Englisch.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.

Zustand: New.

Zustand: New.

Gebunden. Zustand: New.

Paperback. Zustand: Brand New. 260 pages. 9.25x6.10x0.59 inches. In Stock.

Buch. Zustand: Neu. Neuware -The International Symposium on Frontiers in Microbiology has been de dicated to Prof. P. De Somer, whom I succeeded shortly after his death on 17 June 1985 as Rector of this now more than 560-year old University. When Prof. De Somer became the head of the University he started to remodel it, giving our old Alma Mater a more transparent administrative structure, strengthening its scientific and cultural autonomy, and establishing close links with the most prestigious national and foreign institutions. This made De Somer to one of the greatest, if not the greatest, of rectors in the history of Belgian Universities. He was a great leader, a perfect organizer, a clever negotiator, and a brilliant orator. In his speeches one immediately sensed his intuitive cognition and witty evaluation of the values of life. He knew perfectly well how to persuade the unwilling and to disenchant the illusionist. Sometimes a visionary himself, he would not pursue his ideas unless there was a chance of success. As innovative Prof. P. De Somer was in providing to this University a new face, or should I say facelifting, as international is his reputation as the founder, and, since its inception, only director, of the Rega Institute. Built now more than 30 years ago, the Rega Institute has re mained one of the world's leading centers in microbiological research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.

Gebunden. Zustand: New.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The International Symposium on Frontiers in Microbiology has been de dicated to Prof. P. De Somer, whom I succeeded shortly after his death on 17 June 1985 as Rector of this now more than 560-year old University. When Prof. De Somer became the head of the University he started to remodel it, giving our old Alma Mater a more transparent administrative structure, strengthening its scientific and cultural autonomy, and establishing close links with the most prestigious national and foreign institutions. This made De Somer to one of the greatest, if not the greatest, of rectors in the history of Belgian Universities. He was a great leader, a perfect organizer, a clever negotiator, and a brilliant orator. In his speeches one immediately sensed his intuitive cognition and witty evaluation of the values of life. He knew perfectly well how to persuade the unwilling and to disenchant the illusionist. Sometimes a visionary himself, he would not pursue his ideas unless there was a chance of success. As innovative Prof. P. De Somer was in providing to this University a new face, or should I say facelifting, as international is his reputation as the founder, and, since its inception, only director, of the Rega Institute. Built now more than 30 years ago, the Rega Institute has re mained one of the world's leading centers in microbiological research.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Antiviral chemotherapy has come of age, and, after an initial slow pro gress, the development of new antiviral agents has proceeded at a more rapid pace and the perspectives for their clinical use have increased considerably. Now, 25 years after the first antiviral assay (idoxuridine) was introduced in the clinic, it is fitting to commemorate the beginning of the antivirals' era. In its introductory chapter B.E. Juel-Jensen touches on what may be con sidered as five of the most fundamental requirements of an antiviral drug : efficacy, relative non-toxicity, easy solubility, ready availability and rea sonable cost. Surely, the antiviral drugs that have so far been used in the clinic could still be improved upon as one or more of these five essential demands are concerned. How is all began is narrated by W.H. Prusoff. The first antiviral drugs to be used in humans were methisazone and idoxuridine, the former, which is now of archival interest, in the prevention of smallpox, the latter, which was approved for clinical use in the United States in 1962, for the topical treatment of herpetic keratitis. In terms of potency, also because of solubility reasons, idoxuridine has been superseded by trifluridine in the topical treatment of herpes simplex epithelial keratitis. H.E. Kaufman did not find trifluridine or acyclovir ef fective in the treatment of deep stromal keratitis or iritis and he reckons that other antiviral drugs (i.e. bromovinyldeoxyuridine) would not be effec tive either.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The International Symposium on Frontiers in Microbiology has been de dicated to Prof. P. De Somer, whom I succeeded shortly after his death on 17 June 1985 as Rector of this now more than 560-year old University. When Prof. De Somer became the head of the University he started to remodel it, giving our old Alma Mater a more transparent administrative structure, strengthening its scientific and cultural autonomy, and establishing close links with the most prestigious national and foreign institutions. This made De Somer to one of the greatest, if not the greatest, of rectors in the history of Belgian Universities. He was a great leader, a perfect organizer, a clever negotiator, and a brilliant orator. In his speeches one immediately sensed his intuitive cognition and witty evaluation of the values of life. He knew perfectly well how to persuade the unwilling and to disenchant the illusionist. Sometimes a visionary himself, he would not pursue his ideas unless there was a chance of success. As innovative Prof. P. De Somer was in providing to this University a new face, or should I say facelifting, as international is his reputation as the founder, and, since its inception, only director, of the Rega Institute. Built now more than 30 years ago, the Rega Institute has re mained one of the world's leading centers in microbiological research.

Paperback. Zustand: Brand New. 338 pages. 9.21x6.14x0.70 inches. In Stock.

Zustand: Hervorragend. Zustand: Hervorragend | Sprache: Englisch | Produktart: Bücher.