clercq erik (34 Ergebnisse)

Hardcover. Zustand: Wie neu. XI, 243 S.; Ill. Like new. Shrink wrapped. Sprache: Englisch Gewicht in Gramm: 855.

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,950grams, ISBN:0306416182.

2004th ed. 15 x 23 cm. 254 pages. HC Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Sprache: Englisch.

Zustand: New. In.

Zustand: New. In.

Paperback. Zustand: Brand New. reprint edition. 322 pages. 9.61x6.69x0.73 inches. In Stock.

Hardcover. Slight stain to lower RH edges, o/wise good condition in dj. Part of the NATO ASI series, Series A: Life Sciences Vol. 26. x, 459pp. ISBN 0306403021. 11436.

Zustand: New. In.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Antiviral Chemotherapy: An Introduction and Reasons for the Slow Progress, Particularly towards Rational Design.- Design of Nucleoside Analogs as Potential Antiviral Agents.- Design of Anti-Viral Agents other than Nucleoside Analogues.- Antivirals for High Hazards Viruses.- Human Retroviruses and Anti-Viral Therapies.- Epstein-Barr Virus.- Molecular Targets for Selective Antiviral Chemotherapy.- Inhibition of S-Adenosylmethionine-Dependent Transmethylation as an Approach to the Development of Antiviral Agents.- Assay Systems: Testing of Antiviral Drugs in Cell Culture (in vitro).- Animal Models as Assay Systems for the Development of Antivirals.- Experimental Aspects of Antiviral Pharmacology.- Virus Drug Resistance.- Interferon as an Antiviral Agent.- Risk-Benefit Analysis in Drug Research.- Safety Assessment of Antiviral Drugs.- Antiviral Agents: A New Beginning.- Participants.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This pUblication contains the Review Lectures presented at a joint NATO Advanced Study Institute and FEES Advanced Study Course held at Les Arcs, Bourg-8aint-Maurice, France, from the 19th June - 2nd July 1983. The Course, entitled 'Targets for the Design of Antiviral Agents' was in some ways a sequel to the NATO-FEES Course held at SOGESTA (near Urbino), Italy from the 7th - 18th May 1979 and published as volume A26 in this series. During the subsequent four years, we have witnessed the first of the 'new generation' of antiviral compounds, which are more efficacious and less toxic than the 'classical' antiviral drugs, reach the clinic and we felt that it w~s the right time to assess the future prospects of this verY important and exciting field. The vast majority of the drugs developed recently have proved active against various members of the herpesvirus family and elsewhere in this publication we learn that the cure for only rather few viral diseases, such as the common cold, influenza and herpes, promises the return on investment required by the pharmaceutical industry. However, the aim of this Course was for eminent virologists to identify possible targets among the various virus classes against which the chemists could then design suitable therapeutic agents. Recent advances with antiherpesvirus drugs have shown that a far greater selectivity and therapeutic index can be obtained than was previously thought to be possible.

Hardcover. Good condition. No dj. Part of the NATO ASI series, Series A: Life Sciences Vol. 26. x, 459pp. ISBN 0306403021. 11436.

Zustand: New. In.

Zustand: New. In.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.

Zustand: New.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.

Zustand: New.

Zustand: New. In.

Zustand: New. In.

Zustand: New. In.

Zustand: New. In.

Paperback. Zustand: Brand New. 260 pages. 9.25x6.10x0.59 inches. In Stock.

Zustand: New. Offers an extensive assessment of combination therapy of AIDS. In this book, the main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. It also includes chapters that cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology. Editor(s): De Clercq, Erik; Vandamme, Anne-Mieke. Series: Milestones in Drug Therapy. Num Pages: 254 pages, biography. BIC Classification: MJCJ2. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 163 x 22. Weight in Grams: 532. . 2003. Hardback. . . . . Books ship from the US and Ireland.

Zustand: New.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Antiviral chemotherapy has come of age, and, after an initial slow pro gress, the development of new antiviral agents has proceeded at a more rapid pace and the perspectives for their clinical use have increased considerably. Now, 25 years after the first antiviral assay (idoxuridine) was introduced in the clinic, it is fitting to commemorate the beginning of the antivirals' era. In its introductory chapter B.E. Juel-Jensen touches on what may be con sidered as five of the most fundamental requirements of an antiviral drug : efficacy, relative non-toxicity, easy solubility, ready availability and rea sonable cost. Surely, the antiviral drugs that have so far been used in the clinic could still be improved upon as one or more of these five essential demands are concerned. How is all began is narrated by W.H. Prusoff. The first antiviral drugs to be used in humans were methisazone and idoxuridine, the former, which is now of archival interest, in the prevention of smallpox, the latter, which was approved for clinical use in the United States in 1962, for the topical treatment of herpetic keratitis. In terms of potency, also because of solubility reasons, idoxuridine has been superseded by trifluridine in the topical treatment of herpes simplex epithelial keratitis. H.E. Kaufman did not find trifluridine or acyclovir ef fective in the treatment of deep stromal keratitis or iritis and he reckons that other antiviral drugs (i.e. bromovinyldeoxyuridine) would not be effec tive either.

Zustand: Hervorragend. Zustand: Hervorragend | Seiten: 369 | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.

Zustand: New.

Paperback. Zustand: Brand New. 338 pages. 9.21x6.14x0.70 inches. In Stock.

Zustand: New. Proceedings of the International Symposium on Frontiers in Microbiology, Held Nov. 20-22, in Leuven, Belgium, in Honour of Prof. P. de Somer Editor(s): De Clercq, Erik. Series: New Perspectives in Clinical Microbiology. Num Pages: 314 pages, biography. BIC Classification: MMFM. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 235 x 155 x 19. Weight in Grams: 647. . 1987. Hardback. . . . . Books ship from the US and Ireland.

Zustand: New. Editor(s): De Clercq, Erik. Series: Developments in Medical Virology. Num Pages: 414 pages, biography. BIC Classification: MMFM. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 234 x 156 x 23. Weight in Grams: 1730. . 1988. Hardback. . . . . Books ship from the US and Ireland.