Christopher j donnelly (12 Ergebnisse)

Hardcover. Zustand: Good - Cash. Zustand des Schutzumschlags: Fair. General use wear, surface and edges rubbed. Corners bumped and show wear. Pages show reader wear. Secure pages, solid binding. Dust jacket has heavy wear, chipping, tears, and missing pieces. Stock photos may not look exactly like the book.…

paperback. Zustand: Fine. New & unread, however may have light shelf wear to cover face, edges or corners. Shipped from the UK within 2 business days of order being placed. Garces, A.J.; Woodroffe, David; Donnelly, Karen (illustrator).

Paperback. Zustand: Good. No Jacket. Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.

Soft cover. Zustand: Very Good. Close to new condition with no damage or markings to pages and only very light wear to cover. Spine flat and uncreased. 2001 paperback, 1st impression. The photo is of the actual book you will receive. Fast dispatch from UK seller.

paperback. Zustand: New. Shipped from the UK within 2 business days of order being placed. Garces, A.J.; Woodroffe, David; Donnelly, Karen (illustrator).

Hardcover. Zustand: Very Good. No Jacket. May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less.

Zustand: New. In English.

Zustand: New. In English.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre---mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--- coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, dependingon the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi---directional transcription and production of repeat associated non---ATG (RAN) translation products.This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer's disease, Huntington's disease, spinal muscular atrophy, myotonic dystrophy and ataxias.The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters willtherefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.…

Taschenbuch. Zustand: Neu. RNA Metabolism in Neurodegenerative Diseases | Rita Sattler (u. a.) | Taschenbuch | Advances in Neurobiology | xx | Englisch | 2019 | Springer | EAN 9783030078324 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. …

Hardcover. Zustand: Brand New. 332 pages. 9.25x6.10x0.79 inches. In Stock.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.