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Taschenbuch. Zustand: Neu. Proteases in Physiology and Pathology | Naranjan S. Dhalla (u. a.) | Taschenbuch | xv | Englisch | 2018 | Springer Singapore | EAN 9789811096365 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Pathophysiological Aspects of Proteases | Naranjan S. Dhalla (u. a.) | Taschenbuch | xv | Englisch | 2018 | Springer Singapore | EAN 9789811355790 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Oxidative Stress in Microbial Diseases | Sajal Chakraborti (u. a.) | Taschenbuch | xx | Englisch | 2020 | Springer Singapore | EAN 9789811387654 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Role of Proteases in Cellular Dysfunction | Naranjan S. Dhalla (u. a.) | Taschenbuch | xi | Englisch | 2016 | Springer | EAN 9781493946341 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Regulation of Membrane Na+-K+ ATPase | Sajal Chakraborti (u. a.) | Taschenbuch | xi | Englisch | 2019 | Springer | EAN 9783319796727 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Proteases in Health and Disease | Sajal Chakraborti (u. a.) | Taschenbuch | xv | Englisch | 2016 | Humana | EAN 9781493948536 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 420 | Sprache: Englisch | Produktart: Bücher.

Buch. Zustand: Neu. Neuware -This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 692 pp. Englisch.

Buch. Zustand: Neu. Neuware -In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases,this book willhighlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will bewritten by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 420 pp. Englisch.

Buch. Zustand: Neu. Neuware -Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development.This in-depth, comprehensive is avaluable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 636 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases,this book willhighlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will bewritten by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 420 pp. Englisch.

Buch. Zustand: Neu. Neuware -It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer¿s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues.Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 476 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 588 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 588 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 692 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Na+-K+ATPase or Na-pump ATPase, a member of ¿P¿-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it¿s ¿- and ¿- subunits. At present four different ¿- (¿-1,¿-2,¿-3 and ¿-4) and three ¿- (¿-1, ¿-2, and ¿-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ATPase is either mediated by changes in intracellular Na+concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of ¿- and ¿- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a commonsignature sequence encompassing the transmembrane domain adjacent to the isoform(s) of ¿-¿ subunits of Na+-K+ATPase. Considering the extraordinary importance of Na+-K+ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled¿Regulation of Membrane Na+-K+ATPase¿for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ATPase regulation in health and disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Buch. Zustand: Neu. Neuware -Na+-K+ATPase or Na-pump ATPase, a member of ¿P¿-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it¿s ¿- and ¿- subunits. At present four different ¿- (¿-1,¿-2,¿-3 and ¿-4) and three ¿- (¿-1, ¿-2, and ¿-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ATPase is either mediated by changes in intracellular Na+concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of ¿- and ¿- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a commonsignature sequence encompassing the transmembrane domain adjacent to the isoform(s) of ¿-¿ subunits of Na+-K+ATPase. Considering the extraordinary importance of Na+-K+ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled¿Regulation of Membrane Na+-K+ATPase¿for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ATPase regulation in health and disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Zustand: New. pp. 449.

Zustand: New.