B w thayer (4 Ergebnisse)

Hardcover. Zustand: Brand New. 256 pages. 11.00x10.00x1.00 inches. In Stock.

Soft cover. Zustand: Good. 1st Edition. 1 score (5 pages) : 32 cm. Original 1850 first edition sheet music for the song "Ossian's Serenade,"composed and sung by the prominent 19th-century American vocalist, comic singer, and publisher Ossian Euclid Dodge. Published in Boston by Oliver Ditson, the cover features a famous lithograph by [B.W. Thayer & Co.] depicting a highly publicised historical event from that year. Historical Background The trio featured on the front cover includes: Ossian E. Dodge (Left): The singer and songwriter. Phineas Taylor (P.T.) Barnum (Centre): The legendary American showman and entrepreneur. Jenny Lind (Right): The renowned Swedish opera soprano widely celebrated as the "Swedish Nightingale". The text underneath the illustration reads: "P.T. Barnum introducing Madelle. Jenny Lind to Ossian E. Dodge, The 'Boston Vocalist,' & purchaser of the $625 ticket for the first Concert of the Swedish Nightingale in Boston." When Barnum brought Jenny Lind to the United States for an unprecedented concert tour in 1850, he drummed up immense public excitement by auctioning off choice seats. To generate publicity for his own musical career, Ossian Dodge aggressively outbid everyone else for the first Boston ticket, paying a massive sum of $625—an astronomical amount of money at the time. Barnum capitalised on this high-profile stunt, and Dodge immortalized the introduction on the cover of this sheet music, leveraging the "Lind Mania" sweeping the nation to sell his own songs.…

Sheetmusic. Prentiss Collection of Marches & Quick Steps #6. Inside date 1842 4 p. 34 cm. Front cover illustration is Indian Muster at Malden, Oct. 11th 1839, by Thayer's Lithographing, Boston. Disbound sheet music splitting at "spine".

First Edition. Doisy received the Nobel Prize in Physiology or Medicine in 1943 for determining the chemical nature of vitamin K, the fat-soluble compound whose absence from the diet produces uncontrolled hemorrhage by impairing the blood's ability to clot. The vitamin had been identified as a distinct nutritional factor by Henrik Dam in 1935, but its chemical identity remained unknown until Doisy's laboratory at Saint Louis University isolated, characterized, and synthesized both of its naturally occurring forms. The four papers gathered here trace that achievement in compact form: two brief 1939 communications establishing the antihemorrhagic activity of synthetic quinones and proposing a practical standard for their assay; a 1940 note summarizing the structural determinations of vitamins K and K and reporting the preparation of water-soluble derivatives suitable for clinical use; and a major 1941 review consolidating the chemistry, biological testing, and structural elucidation of the entire vitamin K group. Together they document not merely the identification of a vitamin, but the rapid conversion of a nutritional observation into a coherent biochemical program linking isolation, synthesis, standardization, and therapeutic application. Vitamin K is today administered to virtually every newborn in the developed world to prevent fatal bleeding, and remains essential to the management of clotting disorders and anticoagulant therapy. [Thayer, S. A., L. C. Cheney, S. B. Binkley, D. W. MacCorquodale, and E. A. Doisy]. "Vitamin K Activity of Some Quinones; reprinted from the Journal of the American Chemical Society, Vol. 61, p. 1932." Easton, PA: American Chemical Society, 1939. Offprint, single leaf, trimmed 8vo (186 × 199mm). Trimmed at the bottom, old tape offsetting to the margin, else very good. A brief communication reporting the vitamin K activity of an extensive series of quinone derivatives assayed against natural vitamins K and K as standards. Written in direct response to Almquist and Klose's claim that phthiocol was the simplest active member of the antihemorrhagic series, the paper demonstrates that all derivatives of 1,4-naphthoquinone - with the exception of 2-allyl-1,4-naphthoquinone - show measurable vitamin K activity, with 2-methyl-1,4-naphthoquinone the most potent at 10 units per milligram, though markedly less active than the natural vitamins. The activity of two dihydro-1,4-naphthoquinone diacetates is attributed to gastrointestinal hydrolysis, and the paper cross-references the concurrent structural determination of vitamin K published in the same journal volume. [Thayer, S. A., S. B. Binkley, D. W. MacCorquodale, E. A. Doisy, A. D. Emmett, Raymond A. Brown, and Orson D. Bird]. "Vitamin K Potencies of Synthetic Compounds; reprinted from the Journal of the American Chemical Society, Vol. 61, p. 2563, 1939." Easton, PA: American Chemical Society, 1939. Offprint, single leaf, trimmed 8vo (192 × 200mm). Trimmed at the bottom, old tape offsetting to the margin, else very good. A follow-up communication conducted in collaboration with the Research Laboratories of Parke, Davis and Company, supplementing the quinone activity survey of the preceding paper. The principal finding is that 1,4-dihydroxy-2-methylnaphthalene, readily prepared by reduction of 2-methyl-1,4-naphthoquinone, possesses a potency of approximately 1,000 Thayer-Doisy units per milligram and has the clinical advantage of solubility in dilute alkali, making it suitable for intravenous administration in patients unable to absorb oral preparations. The paper concludes with the proposal that 2-methyl-1,4-naphthoquinone be adopted as a universal assay standard, defined as the specific activity of one microgram of the pure compound in League of Nations committee units - a standardization recommendation with immediate practical significance for the clinical deployment of vitamin K therapy. [Doisy, E. A., S. B. Binkley, S. A. Thayer, E. W. McKee, and D. Richert]. "Antihemorrhagic Compounds; reprinted from Science, Vol. 91, No. 2366, p. 421, May 3, 1940." Washington, D.C.: American Association for the Advancement of Science, 1940. Offprint, single leaf, 8vo (230 × 153mm). Soft creases, else fine. A brief communication presented before the National Academy of Sciences, summarizing the structural program following the isolation of both natural antihemorrhagic compounds. The structure of vitamin K was deduced from degradation experiments and confirmed by synthesis; vitamin K , while sharing the 2-methyl-1,4-naphthoquinone core, bears a thirty-carbon hydrocarbon substituent at the 3-position in place of the phytyl chain of K . The water insolubility of both natural compounds limiting their suitability for parenteral use, the authors report the preparation of several water-soluble synthetic derivatives and their intravenous administration to vitamin K-deficient chicks, with activity assessed by restoration of prothrombin time to normal. [Doisy, E. A., S. B. Binkley, and S. A. Thayer]. "Vitamin K; reprinted from Chemical Reviews, Vol. 28, No. 3, pp. 477-517, 1941." Washington, D.C.: American Chemical Society, 1941. Offprint, 8vo (254 × 175mm), pp. 41, [1]. Printed wrappers, staple-bound, rubbing, toning, and light soiling, else very good. A comprehensive review providing an authoritative account of the vitamin K field at the point of its maturity. The paper moves systematically from Dam's original identification of an unknown fat-soluble antihemorrhagic factor in 1935 through the isolation, structural determination, and synthesis of vitamins K and K , before turning to a detailed structure-activity survey of synthetic quinone derivatives. The isolation sections describe the fractionation of alfalfa and putrefied fish meal that yielded K and K respectively; the structural sections document the deduction of the shared 2-methyl-1,4-naphthoquinone core and the characterization of the differing substituents at the 3-position; and an extensive.…