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Titel: Vascular Smooth Muscle Function in ...

Verlag: Morgan & Claypool

Erscheinungsdatum: 2016

Einband: Paperback

Zustand: Very Good

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Inhaltsangabe:

P�ginas:106G�neros:12:MFG:PhysiologySinopsis:Hypertensionisdefinedbyanincreaseinsystemicbloodpressureabovelimitsconsiderednormal,currentlysetat140mmHgforsystolicand90mmHgfordiastolicpressure.Assumingcentralvenouspressuretobenearzero,meanarterialpressureisdeterminedbytheproductoftotalperipheralresistanceandcardiacoutput.Inmostcasesofessentialhypertension,aswellasinanimalmodelsofhypertension,cardiacoutputanditsmaindeterminants,strokevolumeandheartrate,arenormal,whereastotalperipheralresistanceisincreased.TotalperipheralresistanceisinfluencedbyanumberoffactorsdescribedbythePoiseuilleslaw,themostsignificantofwhichbyfaristhediameterofbloodvesselsofthearterialtree.Sincebloodvesseldiameterisareflectionofbothvascularstructureandactiveregulationofvasculartonethroughmechanismsofvasoconstrictionandvasodilatation,itisgenerallyconsideredthatalterationsintotalperipheralresistancearedirectlydeterminedbyalterationsinvascularsmoothmusclestructureand/orfunction.Thus,complexbloodpressureregulationsystems,includingrenal,nervous,endocrine,immune,andothers,intheirturninfluencedbygeneticorenvironmentalfactors,convergeuponthesamemolecularmechanismsthatcontrolthestructureandfunctionofvascularsmoothmuscle.Inthiswork,ratherthanprovidingtheexhaustivelistofmodificationsinthebloodpressureregulatingsystemsthatultimatelyaffectthevasculatureinhypertension,wewillfocusonthestructuralandfunctionalalterationsofvascularsmoothmuscleperseduringhypertension._,

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“...the authors have succeeded in including enough detail that physiologists and pharmacologists at any career stage, researchers of vascular biology and hypertension, students of cardiovascular physiology, even cardiologists interested in vascular biology, will find this short book very useful to acquire an idea of mechanisms that participate in the contribution that vascular smooth muscle in the wall of blood vessels make to elevated blood pressure.” – Ernesto L. Schiffrin, Physician-in-Chief, Sir Mortimer B. Davis-Jewish General Hospital, Montreal
“The book is user-friendly, clearly written and enriched with many useful and informative figures and photographs. I highly recommend this book to all students, researchers and clinicians interested in the vascular biology of hypertension.” – Rhian M. Touyz, President, International Society of Hypertension
“Without a doubt, I would use this text to conduct in-depth discussions on this subject, as well as I will use this material as a source of study for myself. I congratulate the editors for the choice of both authors, who undoubtedly managed to thoroughly review the vascular smooth muscle cell during hypertensive condition.” – Fernanda Giachini Vitorino, Universidade Federal do Mato Grosso

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