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Vascular Smooth Muscle Function in Hypertension (Colloquium Series on The Developing Brain) - Softcover
Inhaltsangabe
Páginas:106Géneros:12:MFG:PhysiologySinopsis:Hypertensionisdefinedbyanincreaseinsystemicbloodpressureabovelimitsconsiderednormal,currentlysetat140mmHgforsystolicand90mmHgfordiastolicpressure.Assumingcentralvenouspressuretobenearzero,meanarterialpressureisdeterminedbytheproductoftotalperipheralresistanceandcardiacoutput.Inmostcasesofessentialhypertension,aswellasinanimalmodelsofhypertension,cardiacoutputanditsmaindeterminants,strokevolumeandheartrate,arenormal,whereastotalperipheralresistanceisincreased.TotalperipheralresistanceisinfluencedbyanumberoffactorsdescribedbythePoiseuilleslaw,themostsignificantofwhichbyfaristhediameterofbloodvesselsofthearterialtree.Sincebloodvesseldiameterisareflectionofbothvascularstructureandactiveregulationofvasculartonethroughmechanismsofvasoconstrictionandvasodilatation,itisgenerallyconsideredthatalterationsintotalperipheralresistancearedirectlydeterminedbyalterationsinvascularsmoothmusclestructureand/orfunction.Thus,complexbloodpressureregulationsystems,includingrenal,nervous,endocrine,immune,andothers,intheirturninfluencedbygeneticorenvironmentalfactors,convergeuponthesamemolecularmechanismsthatcontrolthestructureandfunctionofvascularsmoothmuscle.Inthiswork,ratherthanprovidingtheexhaustivelistofmodificationsinthebloodpressureregulatingsystemsthatultimatelyaffectthevasculatureinhypertension,wewillfocusonthestructuralandfunctionalalterationsofvascularsmoothmuscleperseduringhypertension._,
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Críticas
“...the authors have succeeded in including enough detail that physiologists and pharmacologists at any career stage, researchers of vascular biology and hypertension, students of cardiovascular physiology, even cardiologists interested in vascular biology, will find this short book very useful to acquire an idea of mechanisms that participate in the contribution that vascular smooth muscle in the wall of blood vessels make to elevated blood pressure.” – Ernesto L. Schiffrin, Physician-in-Chief, Sir Mortimer B. Davis-Jewish General Hospital, Montreal
“The book is user-friendly, clearly written and enriched with many useful and informative figures and photographs. I highly recommend this book to all students, researchers and clinicians interested in the vascular biology of hypertension.” – Rhian M. Touyz, President, International Society of Hypertension
“Without a doubt, I would use this text to conduct in-depth discussions on this subject, as well as I will use this material as a source of study for myself. I congratulate the editors for the choice of both authors, who undoubtedly managed to thoroughly review the vascular smooth muscle cell during hypertensive condition.” – Fernanda Giachini Vitorino, Universidade Federal do Mato Grosso
Reseña del editor
Hypertension is defined by an increase in systemic blood pressure above limits considered normal, currently set at 140 mmHg for systolic and 90 mmHg for diastolic pressure. Assuming central venous pressure to be near zero, mean arterial pressure is determined by the product of total peripheral resistance and cardiac output. In most cases of essential hypertension, as well as in animal models of hypertension, cardiac output and its main determinants, stroke volume and heart rate, are normal, whereas total peripheral resistance is increased. Total peripheral resistance is influenced by a number of factors described by the Poiseuille's law, the most significant of which by far is the diameter of blood vessels of the arterial tree. Since blood vessel diameter is a reflection of both vascular structure and active regulation of vascular tone through mechanisms of vasoconstriction and vasodilatation, it is generally considered that alterations in total peripheral resistance are directly determined by alterations in vascular smooth muscle structure and/or function. Thus, complex blood pressure regulation systems, including renal, nervous, endocrine, immune, and others, in their turn influenced by genetic or environmental factors, converge upon the same molecular mechanisms that control the structure and function of vascular smooth muscle. In this work, rather than providing the exhaustive list of modifications in the blood pressure regulating systems that ultimately affect the vasculature in hypertension, we will focus on the structural and functional alterations of vascular smooth muscle per se during hypertension.
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- VerlagMorgan & Claypool Life Sciences
- Erscheinungsdatum2016
- ISBN 10 1615046844
- ISBN 13 9781615046843
- EinbandTapa blanda
- SpracheEnglisch
- Anzahl der Seiten106
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