Proton Pump Inhibitors (Milestones in Drug Therapy) - Hardcover

 
9783764358976: Proton Pump Inhibitors (Milestones in Drug Therapy)
Hardcover
ISBN 10: 3764358971 ISBN 13: 9783764358976
Verlag: Birkhäuser, 1999

Inhaltsangabe

The discovery and development of the proton pump inhibitor.- The discovery and development of the proton pump inhibitor.- Mechanism of action.- The gastric H, K ATPase.- Inhibition of the gastric proton pump.- The Pharmacology of proton pump inhibitors.- Inhibition of gastric acid secretion.- Consequences of gastric acid inihibition in animals.- Consequences of gastric acid inhibition in man.- The acid tolerance of Helicobacter pylori.- Interactions of proton pump inhibitors and Helicobacter pylori in vivo.- Comparison of different proton pump inhibitors.- Pharmaceutical considerations.- Pharmaceutical considerations.- Clinical experience with proton pump inhibitors.- Helicobacter pylori infection and peptic ulcer disease.- Non-steroidal anti-inflammatory drug-associated ulcers.- Zollinger-Ellison syndrome.- Gastro-oesophageal reflux disease.- Socio-Economic impact of acid-related diseases.- Socio-economic impact of acid-related diseases.

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Reseña del editor

Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi­ bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be­ tween efficacy and safety of a new drug. This goal often involves time and many different specialists.

Reseña del editor

This monograph contains a description of the discovery and development of a antisecretory therapy in the treatment of acid-related diseases: omeprazole, the first proton pump inhibitor. Overviews compare this and other proton pump inhibitors and discuss their pharmacology, including the mechanism of action, the effect on Helicobacter pylori infection, and the consequences of profound inhibition of gastric acid secretion. The pharmaceutic delivery system is described since it constitutes a special problem with this class of drugs. The clinical experience with proton pump inhibitors in acid-related diseases is reviewed with focus on gastro-esophageal reflux disease and peptic ulcer diseases including Helicobacter pylori and NSAID-induced ulcerations and Zollinger-Ellison syndrome. Finally, an overview is presented on the socio-economic impact of proton pump inhibitors in acid-related diseases emphasizing the important aspect of quality of life. The monograph is aimed at a broad readership with an interest in the development problems of this, at present, most commercially successful drug; the pharmacology of a "tailor-made" drug for a specific target; the therapeutic strategies in acid-related diseases; and the dramatic changes in the long-term outcome results of the treatment of peptic ulcer diseases where most patients now can be cured from the disease after only one week of drug therapy.

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Verlag
Birkhäuser
Erscheinungsdatum
1999
Sprache
Englisch
ISBN 10 
3764358971
ISBN 13 
9783764358976
Einband
Tapa dura
Anzahl der Seiten
268
Herausgeber
Olbe Lars
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Nicht verfügbar

Weitere beliebte Ausgaben desselben Titels

9783034897778: Proton Pump Inhibitors (Milestones in Drug Therapy)

Vorgestellte Ausgabe

ISBN 10:  3034897774 ISBN 13:  9783034897778
Verlag: Birkhäuser, 2013
Softcover