Gap Junctions in Development and Disease - Hardcover

 
9783540261568: Gap Junctions in Development and Disease
Hardcover
ISBN 10: 3540261567 ISBN 13: 9783540261568
Verlag: Springer, 2005

Inhaltsangabe

Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.

Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

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Von der hinteren Coverseite

The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed.

Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field.

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Verlag
Springer
Erscheinungsdatum
2005
Sprache
Englisch
ISBN 10 
3540261567
ISBN 13 
9783540261568
Einband
Gebundene Ausgabe
Anzahl der Seiten
296
Herausgeber
Winterhager Elke
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

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