Vector Targeting for Therapeutic Gene Delivery - Hardcover

Über die Autorin bzw. den Autor

David T. Curiel, M.D. heads the Gene Therapy Center of the University of Alabama at Birmingham. His scientific training includes tenure at the National Institutes of Health in Bethesda, Maryland and at the Pulmonary Branch of the National Heart, Lung, and Blood Institute from 1985-1989, as well as a fellowship in Biotechnology at the National Cancer Institute, Navy Medical Oncology Branch from 1989-1990. Dr. Curiel has been at the University of Alabama at Birmingham since 1993 and is currently Director of the Gene Therapy Center as well as Director of the Division of Human Gene Therapy. He is also Jeanne and Anne Griffin Chair of Women's Cancer Research, and Professor of Experimental Gene Therapy at the Free University of Amsterdam. Joanne T. Douglas, Ph.D. is an Assistant Professor in the Division of Human Gene Therapy at the University of Alabama at Birmingham.

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The ability to deliver therapeutic genes effectively is the most important requirement for the success of gene therapy interventions. Representing the discipline’s first authoritative text, Vector Targeting for Therapeutic Gene Delivery clearly presents the most recent advances in target definition technology and the principles underlying the rational design of targeted vectors for gene therapy.

The book’s first section focuses on transductional targeting strategies designed to achieve the selective delivery of the therapeutic gene by both nonviral and viral vectors; the second section discusses transcriptional targeting, in which the therapeutic gene is placed under the control of transcriptional regulatory sequences that are activated in the disease cells, but not in normal cells, and therefore target expression selectively to the tumor cell. Other sections consider the variety of strategies that can be employed to define appropriate cellular targeting moieties and strategies to monitor the extent of gene expression. This book also:

• Provides a theoretical framework for advanced vector design
• Integrates all of the allied sciences relevant to the study of vector targeting
• Includes an expert’s perspective on promising future therapeutic applications

Biotechnology industry researchers, as well as individuals involved with the development of human gene therapies, will find Vector Targeting for Therapeutic Gene Delivery to be a vital addition to their professional libraries.

Aus dem Klappentext

The ability to deliver therapeutic genes effectively is the most important requirement for the success of gene therapy interventions. Representing the discipline’s first authoritative text, Vector Targeting for Therapeutic Gene Delivery clearly presents the most recent advances in target definition technology and the principles underlying the rational design of targeted vectors for gene therapy.

The book’s first section focuses on transductional targeting strategies designed to achieve the selective delivery of the therapeutic gene by both nonviral and viral vectors; the second section discusses transcriptional targeting, in which the therapeutic gene is placed under the control of transcriptional regulatory sequences that are activated in the disease cells, but not in normal cells, and therefore target expression selectively to the tumor cell. Other sections consider the variety of strategies that can be employed to define appropriate cellular targeting moieties and strategies to monitor the extent of gene expression. This book also:

• Provides a theoretical framework for advanced vector design
• Integrates all of the allied sciences relevant to the study of vector targeting
• Includes an expert’s perspective on promising future therapeutic applications

Biotechnology industry researchers, as well as individuals involved with the development of human gene therapies, will find Vector Targeting for Therapeutic Gene Delivery to be a vital addition to their professional libraries.