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Won O. Song and Gary R. Beecher are the authors of Modern Analytical Methodologies in Fat- and Water-Soluble Vitamins, published by Wiley.

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Modern Analytical Methodologies in Fat- and Water-Soluble Vitamins

John Wiley & Sons

Contents

CONTRIBUTORS...........................................................................................................................................xvPREFACE................................................................................................................................................xviiCUMULATIVE LISTING OF VOLUMES IN SERIES................................................................................................................xixPART 1 FAT-SOLUBLE VITAMINSCHAPTER 1 VITAMIN A Thomas Arnhold, Heinz Nau, and Ralph Ruehl........................................................................................31.1. Introduction......................................................................................................................................31.2. Sample Collection, Handling, and Storage..........................................................................................................71.3. Sample Preparation................................................................................................................................81.4. Reference Standards...............................................................................................................................151.5. High-Performance Liquid Chromatography............................................................................................................161.6. Other Liquid Chromatographic Methods..............................................................................................................341.7. Gas Chromatography................................................................................................................................351.8. Capillary Electrophoresis.........................................................................................................................361.9. Bioassays.........................................................................................................................................39References.............................................................................................................................................39CHAPTER 2 VITAMIN D Michael F. Holick.................................................................................................................512.1. Origins of Vitamin [D.sub.2] and Vitamin [D.sub.3]................................................................................................512.2. Metabolism and Biologic Functions of Vitamin D....................................................................................................542.3. Measurement of Vitamin D Bioactivity..............................................................................................................552.4. Modern Methods for Determining the Vitamin D Content in Blood.....................................................................................552.5. Strategies for Determining Circulating Concentrations of 25-Hydroxyvitamin D......................................................................562.6. Strategies for Determining Circulating Concentrations of 1,25-Dihydroxyvitamin D..................................................................662.7. Measurement of 24,25-Dihydroxyvitamin D and 25,26-Dihydroxyvitamin D..............................................................................732.8. Clinical Utility for Assays for Vitamin D and Its Metabolites.....................................................................................742.9. Conclusion........................................................................................................................................76References.............................................................................................................................................77CHAPTER 3 DETERMINATION OF TOCOPHEROLS AND TOCOTRIENOLS IN FOODS AND TISSUES Vieno I. Piironen.......................................................813.1. Introduction......................................................................................................................................813.2. Vitamin E Compounds in Foods and Tissues..........................................................................................................823.3. High-Performance Liquid Chromatography............................................................................................................853.4. Gas Chromatography................................................................................................................................1123.5. Supercritical Fluid Extraction and Chromatography.................................................................................................1123.6. Determination of Stereoisomers....................................................................................................................1133.7. Future Development................................................................................................................................114References.............................................................................................................................................115CHAPTER 4 VITAMIN K Sarah L. Booth, Kenneth W. Davidson, James A. Sadowski, and Gregory G. Dolnikowski................................................1294.1. Introduction......................................................................................................................................1294.2. Determination of Phylloquinone by HPLC............................................................................................................1334.3. Determination of Phylloquinone Metabolites and Hydrogenation Products.............................................................................1464.4. Determination of Menaquinones by HPLC.............................................................................................................1534.5. Other Indicators of Vitamin K Nutritional Status..................................................................................................1554.6. Summary...........................................................................................................................................158References.............................................................................................................................................160CHAPTER 5 SIMULTANEOUS DETERMINATION OF FAT-SOLUBLE VITAMINS IN FOOD, FEED, AND SERUM Ronald R. Eitenmiller and W. O. Landen, Jr......................1715.1. Introduction......................................................................................................................................1715.2. Simultaneous Analysis of Fat-Soluble Vitamins in Food and Feed....................................................................................1725.3. An Integrated Approach to Fat-Soluble Vitamin Analysis of Foods...................................................................................1935.4. Simultaneous Analysis of Fat-Soluble Vitamins in Serum or Plasma..................................................................................1955.5. Concluding Comments...............................................................................................................................215References.............................................................................................................................................215PART 2 WATER-SOLUBLE VITAMINSCHAPTER 6 THIAMIN Ronald R....