Springer us nov 2000 (4 Ergebnisse)

Buch. Zustand: Neu. Neuware - Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.…

Buch. Zustand: Neu. Neuware - This book is a collection of extended versions of the papers presented at the Symposium on Next Generation Wireless Networks, May 26, 2000, New Jersey Institute of Technology, Newark, NJ. Each chapter includes, in addition to technical contributions, a tutorial of the corresponding area. It has been a privilege to bring together these contributions from researchers on the leading edge of the field. The papers were submitted in response to a call for papers aiming to concentrate on the applications and services for the 'next generation,' deliberately omitting the numeric reference so that the authors' vision of the future would not be limited by the definitive requirements of a particular set of standards. The book, as a result, reflects the top-down approach by focusing on enabling technologies for the applications and services that are the defining essentials for future wireless networks. This approach strikes a balance between the academia and the industry by addressing new wireless network architectures enabling mobility and location enhanced applications and services that will give wireless systems the competitive edge over others. The main theme of the book is the advent of wireless networks as an irreplaceable means of global communication as opposed to a mere substitute for, or a competitor of, wireline networks. Geolocation emerges as the facilitator of mobility and location sensitive services. The fields of geolocation and wireless communications have been forced to merge, following the Federal Commission of Communications' (FCC) ruling that obliges wireless providers with emergency caller geolocation.…

Buch. Zustand: Neu. Neuware - The Eastern Enlargement of the EU identifies the major fiscal challenges facing Central European countries on the road to European Union accession. The Introduction and three other chapters are on broad macro-economic issues, and four `sectoral' chapters follow these on such questions as the fiscal impact of pensions, health reform, taxation and agricultural policies. A comprehensive analysis of tax systems and of the major elements of public social expenditures (pensions and health care systems) is presented. This analysis helps to identify the key factors determining the present size of governments and the need for, and prospects of, fiscal adjustment. In addition, a comparison of fiscal policy is carried out, followed by a long-term fiscal projection until year 2010. The book is relevant to academics in macroeconomics, European studies and transition economics, as well as in public finance and public policy sciences. It should also appeal to a significant professional audience. Policy makers and economists interested in the accession process in EU countries - at ministries, National Banks, research departments of banks, international organizations (the EU Commission, World Bank, IMF, OECD) - will have a strong interest in this book.…

Buch. Zustand: Neu. Neuware - Genetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabetes. The chapters are approachable for those who are not experts in the field of genetics but also comprehensive, so as to serve as an important resource for researchers interested in the genetics of diabetes mellitus. A description of basic concepts of the genetics of complex diseases like type 1 and type 2 diabetes is provided as background. Type 1 diabetes is addressed in chapters exploring genetic determinants that affect the autoimmune process characteristic of type 1 diabetes, the role of the insulin gene in the pathogenesis of type 1 diabetes and additional genes that may impact upon the risk of type 1 diabetes. The impact of genetic determinants on the pathophysiology of type 2 diabetes is covered, as are chapters that address specific genes that are important for the development of type 2 diabetes. Finally, syndromic forms of diabetes, including Maturity Onset Diabetes of the Young and mitochondrial diabetes, and the insight that these disorders provide into more common forms of diabetes are reviewed. Thus, this comprehensive and up-to-date text will serve as an important resource for those actively engaged in research in this area and clinicians treating these patients to provide an up-to-date entrée for those seeking to become more knowledgeable in the area.…