Springer us mai 1990 (8 Ergebnisse)

Buch. Zustand: Neu. Neuware - This book describes a new type of computer aided VLSI design tool, called a VLSI System Planning, that is meant to aid designers dur ing the early, or conceptual, state of design. During this stage of design, the objective is to define a general design plan, or approach, that is likely to result in an efficient implementation satisfying the initial specifications, or to determine that the initial specifications are not realizable. A design plan is a collection of high level design decisions. As an example, the conceptual design of digital filters involves choosing the type of algorithm to implement (e. g. , finite impulse response or infinite impulse response), the type of polyno mial approximation (e. g. , Equiripple or Chebyshev), the fabrication technology (e. g. , CMOS or BiCMOS), and so on. Once a particu lar design plan is chosen, the detailed design phase can begin. It is during this phase that various synthesis, simulation, layout, and test activities occur to refine the conceptual design, gradually filling more detail until the design is finally realized. The principal advantage of VLSI System Planning is that the increasingly expensive resources of the detailed design process are more efficiently managed. Costly redesigns are minimized because the detailed design process is guided by a more credible, consistent, and correct design plan.…

Buch. Zustand: Neu. Neuware - The Symposium on New Drugs provides for an annual forum for academic investigators, research and development personnel from the pharmaceutical and related health care industries, and members of the Food and Drug Administration to discuss important clinical research issues. The Tenth Annual Symposium on New Drugs addressed the problem of whether it was still appropriate to approve antihypertensive agents soley on the endpoint of lowering cuff blood pressure. The initial discussions at this symposium related to the approaches and methods to studying antihypertensive agents. Dr. William Frishman provided a detailed list of the new approaches to the treatment of hypertension and pointed out the many new concepts that are currently active in the development of many new antihypertensive agents. Dr. William White detailed the growing importance of ambulatory blood pressure monitoring to define hypertension and to determine the change in blood pressure due to pharmacologically active agents. Dr. Jay Cohn pointed out the flaws in using cuff blood pressure and detailed the potential virtues of using vascular compliance to identify patients requiring treatment for hypertension. Dr. Thomas Pickering also discussed the potential value of evaluating changes in left ventricular hypertrophy a finding which identifies high risk patients who need to be included in clinical trials. Dr. Michael Weber detailed the issues and suggested refinements in the approaches to clinical trial designs for antihypertensive agents and Dr. Raymond Lipicky discussed the definition of dose-duration and the role of non-Mem and Peak/Through measurements in defining an antihypertensive drug effect.…

Buch. Zustand: Neu. Neuware - This book, and the research it describes, resulted from a simple observation we made sometime in 1986. Put simply, we noticed that many VLSI design tools looked 'alike'. That is, at least at the overall software architecture level, the algorithms and data structures required to solve problem X looked much like those required to solve problem X'. Unfortunately, this resemblance is often of little help in actually writing the software for problem X' given the software for problem X. In the VLSI CAD world, technology changes rapidly enough that design software must continually strive to keep up. And of course, VLSI design software, and engineering design software in general, is often exquisitely sensitive to some aspects of the domain (technology) in which it operates. Modest changes in functionality have an unfortunate tendency to require substantial (and time-consuming) internal software modifications. Now, observing that large engineering software systems are technology dependent is not particularly clever. However, we believe that our approach to xiv Preface dealing with this problem took an interesting new direction. We chose to investigate the extent to which automatic programming ideas cold be used to synthesize such software systems from high-level specifications. This book is one of the results of that effort.…

Buch. Zustand: Neu. Neuware - If you have ever hiked up a steep hill to reach a viewpoint, you will know that sensing can involve the expenditure of effort. More generally, the choice of which movement an intelligent system chooses to make is usually based on information gleaned from sensors. But the information required to make the motion decision may not be immediately to hand, so the system . first has to plan a motion whose purpose is to acquire the needed sensor information. Again, this conforms to our everyday experience: I am in the woods and don't know which direction to go, so I climb up to the ridge to get my bearings; I am lost in a new town, so I plan to drive to the next junction where there is sure to be a roadsign, failing that I will ask someone who seems to be from the locality. Why, if experiences such as these are so familiar, has the problem only recently been recognised and studied in Robotics One reason is that until quite recently Robotics research was dominated by work on robot arms with limited reach and fixed in a workcell.…

Buch. Zustand: Neu. Neuware - The early history and development of the field of glycolipids was concerned mainly with the predominant glycolipids found in higher animal tissues, namely the glycosphingolipids, as has been extensively documented by J. N. Kanfer and S. Hakomori in Volume 3 of this series. The major glycolipids in organisms of the plant kingdom, however, such as bacteria, yeasts and fungi, algae, and higher plants, are glycoglycerolipids, although glycosphingolipids are also present as minor components in these organisms, except for bacteria. It is of interest that one of the pioneers in glycosphingolipid research, Herbert E. Carter, also pioneered the discovery and structural elucidation of the plant galactosyldiacylglycerols. This class of glycolipids is present in chlo roplast membranes and must surely be one of the most ubiquitous and abun dant natural substances in the world, thereby deserving the attention of lipid biochemists. It is therefore surprising to learn that in contrast to the glycosphingolipids, which were discovered in the 1870s, glycoglycerolipids were not discovered until the 1950s. Since that time investigations of the structure and distribution of these glycolipids have proceeded at an exponen tially increasing rate, and much information is now available for representa tives of many genera of bacteria, yeasts, algae, and higher plants. Glycoglyce rolipids have also been identified in animal cells, particularly in the brain, testes, and sperm.…

Buch. Zustand: Neu. Neuware - Bone marrow transplantation has emerged as a major form of treatment for a broad range of human diseases. Marrow transplantation has many unique biologic features and its principles differ markedly from the transplantation of solid organs. This volume overviews the present status of bone marrow transplantation and summarizes recent progress and controversies. Ad vances in defining the underlying biology of marrow transplantation are discussed. The current status of several major clinical problem areas are reviewed, including engraftment, acute and chronic graft-versus-host dis ease, immunodeficiency, and opportunistic infections. The therapeutic role of allogeneic and autologous bone marrow transplantation is discussed, and results are compared with alternative therapies. lX List of contributors ANASETII, CLAUDIO, M. D. , Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104 APPELBAUM, FRED, M. D. , Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104 ARMITAGE, JAMES 0. , M. D. , Department of Internal Medicine, Univer sity of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105 BEATIY, PATRICK G. , M. D. , Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104 BIERMAN, PHILIP J. , M. D. , Department of Internal Medicine, Univer sity of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105 BUTTURINI, ANNA, M. D. , Department of Pediatrics, University of Parma School of Medicine, Parma, Italy CHAMPLIN, RICHARD, M. D.…

Buch. Zustand: Neu. Neuware - The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and their statistical colleagues: this is the controlled clinical trial. During the past two decades, the evaluation of clinical approaches to pre vention and therapy has become particularly important to clinicians concerned with nervous system dysfunction. There has been and continues to be an explosion of information from the basic neurosciences and from the applica tion of biotechnology to the nervous system.…

Buch. Zustand: Neu. Neuware - Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.…