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Taschenbuch. Zustand: Neu. Neuware - When Critical Issues in Psychiatry was conceived, there were several sub jects I considered to be of crucial importance in a series devoted to residents and clinicians in psychiatry, as well as to other mental health professionals. Of prominence was the pressing need for an in-depth and scholarly exam ination of the interface between medicine and psychiatry. I had been amazed to find that not a single book, to my mind, adequately addressed the psy chological symptoms and manifestations of both common and rare medical illness. It seemed to me that there was a need for a work which would achieve the following goals: First, it would assist in the differential diagnosis of functional psychiatric symptoms versus symptoms secondary to recog nized or unrecognized medical illness; second, it would elucidate the psy chological symptoms resulting from pharmacologic and other therapeutic interventions in medical illness; and third, it would examine the use of psychopharmacological agents in the presence of medical illness and the drugs used to treat that illness. Dr. Jefferson is Board Certified in both internal medicine and psychiatry, and both Drs. Jefferson and Marshall have extensive clinical experience from their many years of consultation/liaison work in psychiatry. Their experience and expertise have resulted in what I believe to be a monumental contri bution to the literature.

Taschenbuch. Zustand: Neu. Neuware - The rapid development of powerful pulsed lasers is at the origin of a conside rable interest in studying the response of an atom, a molecule (or a solid) to a strong electromagnetic field. It is now possible to produce at the laboratory scale, ultra-short 13 pulses with a duration of 100 femtoseconds (10- second) and a power of the order 12 of 1 terawatt (10 Watt). Under these conditions, very high peak intensities may be obtained and electric fields exceeding typical electron binding fields in atoms are generated. The interaction of an atom or a molecule with such electromagnetic fields has a highly non-linear character which leads to unexpected phenomena. Amongst them, - above-threshold ionization (ATI) i.e. the absorption of additional photons in excess of the minimal number necessary to overcome the ionization potential and its molecular counterpart, above-threshold dissociation (ATD); - generation of very high harmonics of the driving field; - stabilization of one-electron systems in strong fields. These processes were the main topics of two international meetings which were held in 1989 and 1991 in the United States under the common name SILAP (Super-Intense Laser-Atom Physics).

Taschenbuch. Zustand: Neu. Neuware - Measurements of the Ion Temperature in Plasmas from Neutron Radiation.- Absolute Scintillation Measurements of Neutron Pulses Generated in a Hot Plasma.- Semiconductor Detectors for Recording Fluxes of Hydrogen Ions with Energies of 1-15 keV.- Recording and Energy Analysis of Low-Energy H1+,H2+, and He+ Ions by Means of Surface-Barrier Silicon Counters.- Device for Plasma Diagnostics with a Multicomponent Beam of Fast Neutral Particles.- Flight-Type Mass Spectrometers for Research on Plasma Bursts.- Experimental Method for Investigating the Energy Losses and the Stability of a Plasma in Toroidal Chambers of the Tokamak Type by Means of a Bolometric Probe.- Thermocouple Method for Determining the Energy Losses in a Plasma and the Distribution of the Energy Losses over the Diaphragm of the Discharge Chamber.- Investigation of the Space- and Time-Dependent Emission Characteristics of a Pulsed Toroidal Penning Discharge.- Measurement of the Correlation Functions of the Light-Emission Intensity in a Plasma-Beam Discharge.- Application of a Correlation Technique for Investigations of the Turbulent Plasma in the Alpha Device.- Investigation of Ionic Cyclotron Oscillations in a Plasma by Means of a Fast-Response Analyzer of the Frequency Spectrum.

Taschenbuch. Zustand: Neu. Neuware - This volume is one outcome of a two-year study conducted by the Behavioral Studies Research Group of The Hastings 1 Center. It is divided into three parts to reflect the several facets of the interdisciplinary project from which it stems. In the opening chapter Willard Gaylin and Ruth Macklin, who di rected the study, describe its basic conception and structure, which centered around three programs to conduct research into aspects of violence and aggressive behavior, programs aborted in the early 1970s because they were politically and IThis project was supported by the EVIST Program of the National Science Foundation under Grant No. 05577-17072, and by a joint award by the National Endowment for the Humanities. Any opinions, findings, conclu sions, or recommendations expressed herein are those of the authors and do not necessarily reflect the views of the National Science Foundation or the National Endowment for the Humanities. Other published outcomes are the edited transcripts of two of the case-study workshops conducted under this project: 'Researching Violence: Science, Politics, and Public Contro versy,' Special Supplement, The Hastings Center Report 9 (April 1979); and 'The XYY Controversy: Researching Violence and Genetics,' Special Sup plement, The Hastings Center Report 10 (August 1980). Copies of these tran scripts are available for purchase from The Hastings Center, 360 Broadway, Hastings-on-Hudson, NY 10706. ix PREFACE x socially controversial.

Taschenbuch. Zustand: Neu. Neuware - The past decade has brought extraordinary gains in the outlook for children stricken with cancer. Though cancer remains a leading cause of death for children and young adults, more victims of child hood cancer today will survive than will die. The therapeutic advances and the optimism they instill have prompted researchers and clinicians to analyze the impact of cancer upon young patients and their famil,ies and to devise more effective intervention strategies. Hope and survival, juxtaposed with the continuing high mortality associated with certain forms of the illness, add new challenges to management of the psychosocial aspects of cancer. To respond to these challenges we need research as rigorous as that which continues to make inroads in treating the physical illness. This specific concern for the needs of children suffering from cancer and their families has paralleled an increasing sensitivity on the part of the medical community and the public at large to the limitations of specialized, high technology health care practices.

Taschenbuch. Zustand: Neu. Neuware - This collection of papers by leading pharmacokineticists and pharmacolo gists is the proceedings of a conference held at the John E. Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R.

Taschenbuch. Zustand: Neu. Neuware - For the last eighteen years we have been deeply involved in a cooperative effort with our Latin American colleagues in genetics, biochemistry, physiology, and molecular biology. We have been in close contact with scientists in a number of centers and have helped to organize symposia, workshops, and so forth, in an effort to accelerate their development and make their substantial work known. These symposia in Latin America have been quite successful. The fifteenth will take place in Brasilia in 1977. At the request of colleagues, we are in the process of developing a similar series in Asia. The first very successful symposium was held in Calcutta in 1973. We were most pleased when Dr. Amir Muhammed, Vice Chancellor of the University of Agriculture, Lyallpur suggested that we hold a symposium on a topic of great importance to Pakistan, Genetic Control of Diversity in Plants, under the auspices of the University of Agriculture. It is our hope that this symposium will be followed by additional ones in Pakistan as well as in other countries in the Far East. Leadership is quickly developing in the hands of outstanding scientists in these countries, and we appreciate the opportunity to cooperate with them. We are especially grateful to the Natiohal Science Foundation for makingPL- 480 funds available which made this symposium possible.

Taschenbuch. Zustand: Neu. Neuware - There is increasing recognition of the biological importance of taurine. Disturbances in taurine metabolism are seen in dysfunction al states as diverse as epilepsy, cardiomyopathy, Friedreich's ataxia and congestive heart failure, which combined with the antiepi1eptic and cardiotonic actions of taurine underscore the emerging clinical importance of this fascinating substance. This is the third book to appear on taurine since 1976. The last book (Taurine and Neuro1oeica1 Disorders, Raven Press, 1978) emphasized the involvement of taurine in central nervous system phenomena. These actions are further explored in this volume. In addition, nutritional aspects of taurine, particularly as these re late to development, have been increasingly recognized to be im portant parts of the taurine story. The marked emphasis placed on nutrition by a number of contributors to this volume is recognition of the meteoritic growth of this area. Are the multitudinous actions of taurine differential expres sions of a universal mechanism There is surprising unity of opinion expressed by the scientists contributing to this volume, despite their differences in viewpoint and background, as the reader, tanta lized we hope by this remark, will discover.

Taschenbuch. Zustand: Neu. Neuware - In this volume, the third of our series, the emphasis has shifted from the theoretical and experimental to the more clinical and practical aspects of alcoholism. Where, in the earlier volumes, more attention was directed to animal than human studies, in this volume, almost all material deals with the human condition. The clinical manifestations of alcoholism may be divided into two major aspects, that of the disease itself and that of its complications. This separation is to some extent artificial since, in a sense, the natural history of the disease is a function of the development of certain complicating mechanisms. These mechanisms in turn either become part and parcel of the underlying condition -alcoholism-or give rise to a new set of clinical variables characterized as 'medical complications. ' At this point, the dichotomy becomes real. The disease alcoholism tends to be seen as a distinct psychosocial entity and to be treated with psychosocial techniques. The 'medical complications' are more clearly envisioned as being within the legitimate domain of medical practice and are treated by physicians who often tend to ignore the underlying alcoholism. The 'patient' is sometimes lost in between. The major thrust of this volume is an attempt to describe the mechanisms of alcoholism as they are now known, in such a way as to establish a continuum between the disease alcoholism and its 'medical complications.

Taschenbuch. Zustand: Neu. Neuware - Since the third Workshop on 'Laser Interaction and Related Plasma Phenomena' in 1973, one area within the scope of this con ference received increased attention: laser fusion. This possi bility was emphasized in February 1977 in a Seminar on US energy policies at The Hartford Graduate Center by John F. O'Leary, Head of the Federal Energy Administration, who said that 'by the year 2100, --- laser fusion will be coming along, giving us a new age of choice'. Efforts in research and development were stepped up to investigate new concepts of laser ignition of controlled nuclear reactions. Here, one expects no radioactive waste from fuel. The deuterium-tritium reaction - the only one which may be possible with magnetic field confinement in tokamaks - has a highly radio active tritium ~ycle, while, in principle, laser reactions are possible with pure deuterium, hydrogen-boron or others. The worldwide progress in laser compression was not only stim ulated by the energy crisis, but also by its advancements. In our first Workshop in 1969 F. F10ux of the French Limei1 Laboratories described his experiments, which led, only one month later, to the production of fusion neutrons in such large numbers as had not been achieved up to then (see appendix of Vol. I these Proceedings).

Taschenbuch. Zustand: Neu. Neuware - The impetus for the conference held at Bombannes, France in May, 1982 arose out of a Scientific Committee on Oceanic Research (SCOR) Working Group on 'Mathematical Models in Biological Oceanography'. This group was chaired by K.H. Mann and held two meetings in 1977 and 1979. At both meetings it was felt that, although reductionist modelling of marine ecosystems had achieved some successes, the future progress lay in the development of holistic ecosystem models. The members of the group (K.H. Mann, T. Platt, J.M. Colebrook, D.F. Smith, M.J.R. Fasham, J. Field, G. Radach, R.E. Ulanowicz and F. Wulff) produced a critical review of reductionist and holistic models which was published by the Unesco Press (Platt, Mann and Ulanowicz, 1981). One of the conclusions of this review was that, whether holistic or reductionist models are preferred, it is critically important to increase the scientific effort in the measurement of physiological rates for the computation of ecological fluxes. The Working Group therefore recommended that an international meeting should be organized which would attempt to bring together theoretical ecologists and biological oceanographers to assess the present and future capability for measuring ecological fluxes and incorporating these data into models. An approach was made to the Marine Sciences Panel of the NATO Science Committee who expressed an interest in funding such a meeting. They awarded a planning grant and a planning group was formed consisting of M.J.R. Fasham, M.V. Angel, T. Platt, R.E.

Taschenbuch. Zustand: Neu. Neuware - This volume is the second in 'The Downstate Series of Research in Psychiatry.' It is aseries devoted to the presentation of sig nificant research with relevance for both clinicians and researchers in the multiple subfields of psychiatry. This book focuses on the interactions between psychic phenomena and physical processes as studied by evoked brain potentials. It presents material concerned with physiological and psychological unifying processes, as weIl as research concerning technology and methods of obtaining meaningful measurements. As such it is representative of biological psychiatry at its best. Thus, it represents another step in new directions in psychiatric research but not an unanticipated direction. Scientific investigation into the human psyche took an unex pected turn when Sigmund Freud in the last part of the 19th Century turned his attention from neurological concerns to those of psychol ogy. His first attempts at explanations as noted in the 'project,' included a heavy emphasis on the biological substrate of behavior.