springer us jul 2005 (24 Ergebnisse)

Buch. Zustand: Neu. Neuware - The Molecular Mechanisms of Axenfeld-Rieger Syndrome describes the current research and clinical findings of the heterogeneous disorder termed Axenfeld-Rieger Syndrome (ARS). The book provides an in-depth analysis of this phenotypic diverse disorder and is designed to detail the current molecular and biochemical research involved in studying genetic defects. This book brings together the complete analysis of a human genetic defect using humans, mouse and chick epigenetic and genetic studies, combined with cell culture and in vitro analyses. It is a comprehensive study of a unique set of genes and their mutant activities. A molecular basis for the genetic and phenotypic anomalies observed in ARS patients is provided, with especially detailed descriptions of eye, tooth, and heart development.

Buch. Zustand: Neu. Neuware - Based on a unique research study, this volume examines the later life development of Holocaust survivors from Israel and the US. Through systematic interviews, the authors noted researchers and clinicians collected data about the lives of these survivors and how they compared to peers who did not share this experience. The orientation of the book synthesizes several conceptual approaches gerontological and life span development, stress research, and traumatology, and also reflects the varied disciplines of the authors, spanning psychology, social work, and sociology. The result is a multi-faceted view of their subject with an understanding of the individual, society, and the interaction of the two, tempered by the authors own Holocaust experiences. Chapters cover a range of areas including stress and coping of these survivors, reviews of their heath and mental health, an examination of their social integration, as well as a review of the multiple predictors of psychological well-being and adaptation to aging. This book will be of interest to psychologists, social workers, sociologists, psychiatrists, and all those who study both trauma and aging.

Buch. Zustand: Neu. Neuware - It is widely acknowledged that the cost of validation and testing comprises a s- nificant percentage of the overall development costs for electronic systems today, and is expected to escalate sharply in the future. Many studies have shown that up to 70% of the design development time and resources are spent on functional verification. Functional errors manifest themselves very early in the design flow, and unless they are detected up front, they can result in severe consequence- both financially and from a safety viewpoint. Indeed, several recent instances of high-profile functional errors (e. g. , the Pentium FDIV bug) have resulted in - creased attention paid to verifying the functional correctness of designs. Recent efforts have proposed augmenting the traditional RTL simulation-based validation methodology with formal techniques in an attempt to uncover hard-to-find c- ner cases, with the goal of trying to reach RTL functional verification closure. However, what is often not highlighted is the fact that in spite of the tremendous time and effort put into such efforts at the RTL and lower levels of abstraction, the complexity of contemporary embedded systems makes it difficult to guarantee functional correctness at the system level under all possible operational scenarios. The problem is exacerbated in current System-on-Chip (SOC) design meth- ologies that employ Intellectual Property (IP) blocks composed of processor cores, coprocessors, and memory subsystems. Functional verification becomes one of the major bottlenecks in the design of such systems.

Buch. Zustand: Neu. Neuware - AGENT INTELLIGENCE THROUGH DATA MINING offers a self-contained overview of a relatively young but important area of research: the intersection of agent technology and data mining. This intersection leads to considerable advancements in the area of information technologies, drawing the increasing attention of both research and industrial communities. It can take two forms: a) the more mundane use of intelligent agents for improved data mining and; b) the use of data mining for smarter, more efficient agents. The second approach is the main focus of this volume.Knowledge, routinely created and maintained by today s applications, is hidden in voluminous data repositories that can be extracted by data mining. The next step is to transform this discovered knowledge into the inference mechanisms or simply the behavior of agents and multi-agent systems. AGENT INTELLIGENCE THROUGH DATA MINING addresses this issue, as well as the arguable challenge of generating intelligence from data while transferring it to a separate, possibly autonomous, software entity. Following a brief review of data mining and agent technology fields, this book presents a methodology for developing multi-agent systems, describes available open-source tools to support this process, and demonstrates the application of the methodology on three different cases.AGENT INTELLIGENCE THROUGH DATA MINING is designed for a professional audience composed of researchers and practitioners in industry. This volume is also suitable for graduate-level students in computer science.

Buch. Zustand: Neu. Neuware - Nanotechnology has received tremendous interest over the last decade, not only from the scientific community but also from a business perspective and from the general public. Although nanotechnology is still at the largely unexplored frontier of science, it has the potential for extremely exciting technological innovations that will have an enormous impact on areas as diverse as information technology, medicine, energy supply and probably many others. The miniturization of devices and structures will impact the speed of devices and information storage capacity. More importantly, though, nanotechnology should lead to completely new functional devices as nanostructures have fundamentally different physical properties that are governed by quantum effects. When nanometer sized features are fabricated in materials that are currently used in electronic, magnetic, and optical applications, quantum behavior will lead to a set of unprecedented properties. The interactions of nanostructures with biological materials are largely unexplored. Future work in this direction should yield enabling technologies that allows the study and direct manipulation of biological processes at the (sub) cellular level.

Buch. Zustand: Neu. Neuware - Broadband is a key enabler of the information society, increasing productivity and competitiveness across all sectors of the economy. Unlike traditional n- rowband connections, broadband provides high speed, always-on connections to the Internet and supports innovative content and services. Direct consumer welfare gains from mass-market adoption of broadband across the EU could easily reach 50 billion euros or more per annum. This is quite apart from the more profound societal shifts that ubiquitous broadband could bring. It may allow the individual to distribute content and ideas independent of traditional media and bring together communities of interest without regard to borders. Public policy for broadband will have a big impact on whether and how quickly these bene ts are realised. Getting policy right could bring large bene ts for consumers, rms and the economy at large; getting policy wrong risks s- ing both the rollout of broadband and new innovative services, and thus the realisation of the EU's e-Europe vision. In this book, we focus on the residential market for broadband access in EU countries, analysing the current and prospective level of competition and dr- ing implications for public policy. A key aim is to understand better the relative importance of facilities-based and access-based provision in fostering com- tition and promoting take-up of broadband services.

Buch. Zustand: Neu. Neuware - Motion-Free Super-Resolution is a compilation of very recent work on various methods of generating super-resolution (SR) images from a set of low-resolution images. The current literature on this topic deals primarily with the use of motion cues for the purpose of generating SR images. These cues have, it is shown, their advantages and disadvantages. In contrast, this book shows that cues other than motion can also be used for the same purpose, and addresses both the merits and demerits of these new techniques. Motion-Free Super-Resolution supersedes much of the lead author's previous edited volume, 'Super-Resolution Imaging,' and includes an up-to-date account of the latest research efforts in this fast-moving field. This sequel also features a style of presentation closer to that of a textbook, with an emphasis on teaching and explanation rather than scholarly presentation.

Buch. Zustand: Neu. Neuware - A tutorial approach to using the UML modeling language in system-on-chip designBased on the DAC 2004 tutorial, applicable for students and professionalsContributions by top-level international researchersThe best work at the first UML for SoC workshopUnique combination of both UML capabilities and SoC design issuesCondenses research and development ideas that are only found in multiple conference proceedings and many other books into one placeWill be the seminal reference work for this area for years to come.

Buch. Zustand: Neu. Neuware - Natural duality theory is one of the major growth areas within general algebra. This text provides a short path to the forefront of research in duality theory. It presents a coherent approach to new results in the area, as well as exposing open problems.Unary algebras play a special role throughout the text. Individual unary algebras are relatively simple and easy to work with. But as a class they have a rich and complex entanglement with dualisability. This combination of local simplicity and global complexity ensures that, for the study of natural duality theory, unary algebras are an excellent source of examples and counterexamples.A number of results appear here for the first time. In particular, the text ends with an appendix that provides a new and definitive approach to the concept of the rank of a finite algebra and its relationship with strong dualisability.

Buch. Zustand: Neu. Neuware - One of the most civilized nations in history, China has a long-standing writing tradition and many Chinese texts have become world treasures. However, the way the Chinese teach writing in various countries in contemporary times is little known to the outside world, especially in Western countries. Undoubtedly, the Chinese have had an established traditional method of writing instruction. However, recent social and political developments have created the perception amongst both practitioners and researchers of a need for change. Whilst certain socio-political changes, both in Mainland China and in the territories, acted as agents for reform of the teaching of composition, the shape these reforms are taking has been due to many different influences, coming both from inside the countries themselves and from foreign sources. Mainland China, Hong Kong, Taiwan and Singapore have each developed their own approach to the teaching of composition.

Buch. Zustand: Neu. Neuware - As the drug abuse epidemic evolves, so do the tools needed to understand and treat it. Accordingly, Epidemiology of Drug Abuse takes the long view, cogently outlining what the book calls 'the natural history of drug abuse' and redefining its complex phenomena to reflect our present-day knowledge. Twenty-six eminent contributors discuss the state and future of the field, balancing the practical concerns involved in gathering drug abuse data with the ethics of using the information.- Current thinking on pathways and etiology, as well as medical, psychological, and social sequelae of drug abuse- Proven, up-to-date methodologies for assessment- Challenges of gathering data from high-risk and other user populations- Sampling and application issues- Uses, sources, and limitations of treatment data- Analytical papers applying the methodologies to specific and global studies - The role of epidemiology studies in developing prevention strategiesWith this multifaceted approach to the subject, Epidemiology of Drug Abuse provides researchers and educators with a reference that sheds significant light on infrequently covered areas. In addition, its breadth and accessibility of coverage make it a teaching text suitable to courses in epidemiology, public health, and drug abuse.

Buch. Zustand: Neu. Neuware - Knowledge Management and Management Learning: Extending the Horizons of Knowledge-Based Management examines a range of topical considerations in the field by utilizing dynamic and non-linear systems behavior or the complexity paradigm. From this examination have come a number of new and promising relevant extensions to knowledge management and its practice. Many of the topics have been pulled from 'real world' situations in actual companies, and therefore these topical treatments reflect quantitative and qualitative research done within the knowledge management framework of actual company experience. Offered are a series of topical treatments that extend the parameters of knowledge management and examine the practical implications of these extensions.The book begins with an extended introduction and theoretical framework. The contributing authors have written chapters that add to both the framework and the practical consequences of knowledge management. Within this context, the book illustrates why and how of knowledge management is important for companies.

Buch. Zustand: Neu. Neuware - This unique book, drawing on the author's lifetime experience, critically evaluates the extensive literature on the field of Metal-Catalysed Reactions of Hydrocarbons. Emphasis is placed on reaction mechanisms involving hydrogenation, hydrogenolysis, skeletal and positional isomerisation, and exchange reactions. The motivation for fundamental research in heterogeneous catalysis is to identify the physicochemical characteristics of active centres for the reaction being studied, to learn how these may be modified or manipulated to improve the desired behavior of the catalyst, and to recognize and control those aspects of the catalyst's structure that limit its overall performance. By restricting the subject of the book to hydrocarbons, Bond has progressively developed the subject matter to include areas of importance both to researchers and to those working in the industry.

Buch. Zustand: Neu. Neuware - In spite of the remarkable progress that has been made against cancer, the battle is far from over. It is estimated that there are 175,000 new female breast cancer cases, annually, and 40,000 deaths resulting from it in the U. S. In fact, breast cancer incidence rates have shown little change in the 1990s, while breast cancer death rates have been declining about 2percentperyearsince1990[Riesetal. ,1999]. Modernmammographyisrelieduponmost often for breast cancer screening. Mammograms can detect most breast cancers, but they miss some. Its accuracy and sensitivity are age and breast density dependent. For example, the false negative rate is about 25% for women under age 50, with invasive breast cancer [Kerlikowske et al. , 1996; 1997]. It reduces to 10% for women more than 50 years of age. Although the amount of radiation exposure during mammography is minimal - about the same as receiving a dental x-ray, the radiation from mammograms can cause additional breast cancer deaths [Feig, 1996; NIH, 1997]. (It has been estimated that if 10,000 women have yearly mammograms for ten years, the radiation from mammograms will cause one additional breast cancer death. ) Because the absolute bene t of screening women aged 40 to 49 years is small and there is concern that the harm may be substantial, there have been suggestions that these women should be informed about the potential bene ts and risks of screening mammography [Kerlikowske, 1997].

Buch. Zustand: Neu. Neuware - Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs.Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapyfor autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Buch. Zustand: Neu. Neuware - Design of Wireless Autonomous Dataloggers IC's reveals the state of the art in the design of complex dataloggers, with a special focus on low power consumption. The emphasis is on autonomous dataloggers for stand-alone applications with remote reprogrammability.The book starts with a comprehensive introduction on the most important design aspects and trade-offs for miniaturized low-power telemetric dataloggers. After the general introduction follows an in-depth case study of an autonomous CMOS datalogger IC for the registration of in vivo loads on oral implants. After tackling the design of the datalogger on the system level, the design of the different building blocks is elaborated in detail, with emphasis on low power. A clear overview of the operation, the implementation, and the most important design considerations of the building blocks to achieve optimal system performance is given. Design of Wireless Autonomous Dataloggers IC's discusses the design of correlated double sampling amplifiers and sample-and-holds, binary-weighted current steering DACs, successive approximation ADCs and relaxation clock oscillators and can also be used as a manual for the design of these building blocks. Design of Wireless Autonomous Dataloggers IC's covers the complete design flow of low-power miniaturized autonomous dataloggers with a bi-directional wireless link and on-board data processing, while providing detailed insight into the most critical design issues of the different building blocks. It will allow you to design complex dataloggers faster. It is essential reading for analog design engineers and researchers in the field of miniaturized dataloggers and is also suitable as a text for an advanced course on the subject.

Buch. Zustand: Neu. Neuware - Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

Buch. Zustand: Neu. Neuware - Oxides form a broad subject area of research and technology development which encompasses different disciplines such as materials science, solid state chemistry, physics etc. The aim of this book is to demonstrate the interplay of these fields and to provide an introduction to the techniques and methodologies involving film growth, characterization and device processing. The literature in this field is thus fairly scattered in different research journals covering one or the other aspect of the specific activity. This situation calls for a book that will consolidate this information and thus enable a beginner as well as an expert to get an overall perspective of the field, its foundations, and its projected progress.

Buch. Zustand: Neu. Neuware - Fiber-optic communication systems have revolutionized our telecommunication infrastructures - currently, almost all telephone land-line, cellular, and internet communications must travel via some form of optical fibers. In these transmission systems, neither the phase nor frequency of the optical signal carries information - only the intensity of the signal is used. To transmit more information in a single optical carrier, the phase of the optical carrier must be explored.As a result, there is renewed interest in phase-modulated optical communications, mainly in direct-detection DPSK signals for long-haul optical communication systems. When optical amplifiers are used to maintain certain signal level among the fiber link, the system is limited by amplifier noises and fiber nonlinearities. Phase-Modulated Optical Communication Systems surveys this newly popular area, covering the following topics:- The transmitter and receiver for phase-modulated coherent lightwave systems- Method for performance analysis of phase-modulated optical signals- Direct-detection DPSK signal with fiber nonlinearities, degraded by nonlinear phase noise and intrachannel effects- Wavelength-division-multiplexed direct-detection DPSK signals- Multi-level phase-modulated optical signals, such as the four-phase DQPSK signal.Graduate students, professional engineers, and researchers will all benefit from this updated treatment of an important topic in the optical communications field.

Buch. Zustand: Neu. Neuware - (R)Evolution studies the adaptation of industrial organisations to the dynamics of the environment by drawing an analogy with evolutionary biology, by extensively studying literature in management science, and by case studies. These investigations have lead to the insight that companies might evolve slower than generally expected; they doubt the effect of reorganizations, as commonly practiced in industry. Additionally, this work proposes the model for the Innovation Impact Point, the model for the Dynamic Adaptation Capability, the model for Collaboration.

Buch. Zustand: Neu. Neuware - This book brings together authors with expertise in a wide range of fields to provide an up to the minute overview of the most important problems relating to mercury in the environment. The book reflects growing concern over the likelihood of harmful effects to human health and sensitive ecosystems posed by mercury in the light of increasing fossil fuel combustion, mercury use in a range of manufactured goods, and the lack of emission control policies. Concern has been expressed at local, national, and international levels; in the last three years both the European Commission and UNEP have published reports on mercury in the environment. Growing concern has led to an increased effort to understand the fate of mercury in the environment, including primary production and trade in mercury, emissions from manufacturing and power generation, natural emissions and re-emission, atmospheric transport and transformation, deposition patterns, uptake by biota, and eventual health impacts on living organisms. The increasing specialisation, and amount of research in the numerous scientific fields associated with the study of the fate of mercury in the environment, make the publication of this book both necessary and timely. For experts, and non-experts, who require both the broader picture, as well as an awareness of the latest progress in the fields relevant to mercury research, this book provides the most comprehensive and up to date overview available. The book has five sections.

Buch. Zustand: Neu. Neuware - Chronic back and neck pain. Whiplash. Fibromyalgia. Carpal tunnel syndrome. Intractable headaches. Depression. Anxiety and posttraumatic stress. Concussion. More than ever, the term workplace disabilities is synonymous with greater clinical and case management complexity and escalating personal, social, occupational and economic cost. Complex illnesses and injuries that defy a traditional medical management model continue to baffle medical, mental health, rehabilitation, compensation, corporate, and legal professionals despite new advances in diagnosis, prevention, and rehabilitation. The Handbook of Complex Occupational Disability Claims: Early Risk Identification, Intervention and Prevention cuts through the confusion by integrating current theories and findings into a state-of-the-art tool for critical thinking, decision making, and effective practice.A book that synthesizes so many diverse viewpoints has the potential to influence both policy and practice across disciplines and cut through politicization of these still poorly understood conditions with evidence. The Handbook is important reading for all clinicians, professionals, and members of rehabilitation and disability management teams, across healthcare, occupational and compensation settings.

Buch. Zustand: Neu. Neuware - This volume is comprised of the proceedings of the 13th International Conference on Information Systems Development held August 26th-28th, 2004, at Vilnius Gediminas Technical University, Vilnius, Lithuania. The aim of this volume is to provide a forum for the research and practices addressing current issues associated with Information Systems Development (ISD). Every day, new technologies, applications, and methods raise the standards for the quality of systems expected by organizations as well as end users. All are becoming dependent on systems reliability, scalability, and performance. Thus, it is crucial to exchange ideas and experiences, and to stimulate exploration of new solutions. This proceedings provides a forum for both technical and organizational issues.

Buch. Zustand: Neu. Neuware - Orthopoxviruses Pathogenic for Humans covers those viruses capable of causing disease in man, including monkeypox, smallpox, cowpox, and vaccinia. The coverage of each virus is comprehensive, covering the biology, molecular biology, and ecology of the virus as well as the clinical and epidemiological aspects of these viruses in humans and animals. In addition, this volume highlights developments in genetic engineering that are paving the way for potential therapeutic treatments of these viruses.