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Taschenbuch. Zustand: Neu. Neuware -Pattern recognition has its origins in engineering, whereas machine learning grew out of computer science. However, these activities can be viewed as two facets of the same field, and together they have undergone substantial development over the past ten years. In particular, Bayesian methods have grown from a specialist niche to become mainstream, while graphical models have emerged as a general framework for describing and applying probabilistic models. Also, the practical applicability of Bayesian methods has been greatly enhanced through the development of a range of approximate inference algorithms such as variational Bayes and expectation pro- gation. Similarly, new models based on kernels have had significant impact on both algorithms and applications. This new textbook reacts these recent developments while providing a comprehensive introduction to the fields of pattern recognition and machine learning. It is aimed at advanced undergraduates or first year PhD students, as wellas researchers and practitioners, and assumes no previous knowledge of pattern recognition or - chine learning concepts. Knowledge of multivariate calculus and basic linear algebra is required, and some familiarity with probabilities would be helpful though not essential as the book includes a self-contained introduction to basic probability theory.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 760 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - From the Preface:This festschrift is devoted to recognize the career of a man who not only witnessed the growth of operations research from its inception, but also contributed significantly to this growth. Dr. Salah E. Elmaghraby received his doctorate degree from Cornell University in 1958, and since then, his scholarly contributions have enriched the fields of production planning and scheduling and project scheduling. This collection of papers is contributed in his honor by his students, colleagues, and acquaintances. It offers a tribute to the inspiration received from his work, and from his guidance and advice over the years, and recognizes the legacy of his many contributions.Dr. Elmaghraby is a pioneer in the area of project scheduling (in particular, project planning and control through network models, for which he coined the term 'activity networks'.) In his initial work in this area, he developed an algebra based on signal flow graphs and semi-Markov processes for analyzing generalized activity networks involving activities with probabilistic durations. This work led to the development of what was later known as the Graphical Evaluation and Review Technique (GERT), and GERT simulation models. He has made fundamental contributions in determining criticality indices for activities, in developing methodologies for project compression and time/cost analysis, and in the use of stochastic and chance-constrained programming and Petri Nets for the analysis of activity networks.This volume brings together fourteen contributions, which can be viewed under the following three main themes: operations research and its application in production planning; project scheduling, and production scheduling, inspired by, and in many cases based on, Dr. Elmaghraby's work in these areas. The first five chapters are devoted to the first theme, followed by four chapters each devoted to the other two, respectively. An additional chapter is devotedto the vulnerability of multimodal freight systems.

Taschenbuch. Zustand: Neu. Neuware - Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on 'Genes and the Heart,' joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.

Taschenbuch. Zustand: Neu. Neuware - This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

Taschenbuch. Zustand: Neu. Neuware - Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies. The purpose of this book is to present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy. The book will start from the historic overview of the subject, including the development of the pacemaker and defibrillator, evolution of theories of cardiac arrhythmias and experimental methods used in the field over the centuries. Leading experts in the field will write these chapters. The second part of the book will focus on rigorous treatment of the fundamental theory of interaction between electric field and cardiac cell, tissue, and organ. Chapters will be written by top notch scientists, who made critically important contributions to the development of these theories. Part 3 will provide summary of several decades of research involving electrode recordings and multielectrode mapping of ventricular fibrillation and defibrillation in humans and animal models of arrhythmias. Part 4 will present new insights into defibrillation gained due to the advent of optical imaging technology, which permitted to map defibrillation without overwhelming shock-induced artifacts present in electrode recordings. Part 5 will provide rigorous overview of themethodologies, which made research of physiological and engineering aspects of electrotherapy possible. And finally, part 6 will present possible future of implantable devices and electrotherapy in the treatment of cardiac rhythm disorders.

Taschenbuch. Zustand: Neu. Neuware -The International Handbook of Research on Teachers and Teaching provides a fresh look at the ever changing nature of the teaching profession throughout the world. This collection of over 70 original articles addresses a wide range of issues that are relevant for understanding the present educational climate in which the accountability of teachers and the standardized testing of students have become dominant.The international collection of authors brings to the handbook a breadth of knowledge and experience about the teaching profession and a wealth of material across a number of comparative dimensions, such as between developed and developing countries and between Eastern and Western cultures. In addition, many articles address the emerging challenges to education and to the lives of teachers which are brought about by the globalization trends of the 21st Century. 1248 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - The International Handbook of Research on Teachers and Teaching provides a fresh look at the ever changing nature of the teaching profession throughout the world. This collection of over 70 original articles addresses a wide range of issues that are relevant for understanding the present educational climate in which the accountability of teachers and the standardized testing of students have become dominant.The international collection of authors brings to the handbook a breadth of knowledge and experience about the teaching profession and a wealth of material across a number of comparative dimensions, such as between developed and developing countries and between Eastern and Western cultures. In addition, many articles address the emerging challenges to education and to the lives of teachers which are brought about by the globalization trends of the 21st Century.