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Taschenbuch. Zustand: Neu. Neuware - The first ACS Adhesion Symposium was held in Washington, D.C., September 1971. During the four years since that meeting, much interest in adhesion has been generated among six divisions of the American Chemical Society. Then, in 1974, the Macromolecular Secretariat appointed me to work closely with the six Session chairmen in organizing this Symposium on Science and Technology of Adhesion. Needless to say, the success of the Symposium which took place between April 7 and 10, 1975 in Philadelphia, Pa., is due to their excellent cooperation and the enthusiastic response of con tributors. As originally planned, each division was responsible for one session, and most of the papers, including several late con tributions, are published in these two volumes of proceedings. During the Symposium, we held a banquet in honor of Professor Herman Mark in celebration of his eightieth birthday. His Plenary Lecture and the Symposium Address by Professor Murray Goodman are published in full at the beginning of the first volume. I thank Professors Mark and Goodman for their excellent presentations on this memorable occasion.

Taschenbuch. Zustand: Neu. Neuware - Examination of the tables of contents of journals - biochemical, molecular biological, ultrastructural, and physiological-provides convincing evidence that membrane biology will be in the 1970s what biochemical genetics was in the 1960s. And for good reason. If genetics is the mechanism for main taining and transmitting the essentials of life, membranes are in many ways the essence of life. The minimal requirement for independent existence is the individualism provided by the separation of 'life' from the environment. The cell exists by virtue of its surface membran~. One might define the first living organism as that stage of evolution where macromolecular catalysts or self-reproducing polymers were first segregated from the surrounding milieu by a membrane. Whether that early membrane resembled present cell membranes is irrelevant. What matters is that a membrane would have provided a mechanism for maintaining a local concentration of molecules, facilitating chemical evolution and allowing it to evolve into biochemical evolution. That or yet more primitive membranes, such as a hydrocarbon monolayer at an air-water interface, could also have provided a surface that would facilitate the aggregation and specific orientation of molecules and catalyze their interactions. If primitive membranes were much more than mere passive barriers to free diffusion, how much more is this true of the membranes of contemporary forms of life. A major revolution in biological thought has been the recogni tion that the cell, and especially the eukaryotic cell, is a bewildering maze of membranes and membranous organelles.

Taschenbuch. Zustand: Neu. Neuware - This volume is the third in the Contemporary Geriatric Medicine series. As in previous volumes, information is presented in the form of easy-to read essays to bring the reader up to date on state-of-the-art develop ments in the area of geriatric medicine. Once again, a system approach is utilized. In addition, several new topics-including alcoholism, throm boembolic disease, and decubitus ulcer management-have been intro duced to enhance this volume's usefulness to the busy clinician and student. Each chapter is not meant to be an exhaustive review of all topics in the field, but rather to focus on issues currently receiving a great deal of attention. Our goal continues to be to create an exciting approach to contemporary issues in geriatric medicine. The editors are once again appreciative for having been given the opportunity to develop this series. Appreciation is also expressed to our professional colleagues, families, and administrative assistants, who have enabled this volume to reach fruition. As in the past, we thank, most of all, our elderly patients for providing the inspiration and impetus to improve our knowledge and understanding of the health care needs of the elderly. Steven R. Gambert, M.D. V alhalla, New York ix Contents Chapter 1 Geriatric Cardiology and Blood Pressure 1 Edmund H. Duthie, Jr., and Michael H. Keelan, Jr.

Taschenbuch. Zustand: Neu. Neuware - The goals of the science of photobiology can be divided into four categories: to develop (I) ways to optimize the beneficial effects of light on man and his environment, (2) methods to protect organisms, including man, from the detrimental effects of light, (3) photochemical tools for use in studies of life processes, and (4) photochemical therapies in medicine. To achieve these goals will require the knowledgeable collaboration of biologists, chemists, engineers, mathematicians, physicians, and physicists; because photobiology is a truly multidisciplinary science. While a multidis ciplinary science is more intellectually demanding, it also has a greater potential for unexpected breakthroughs that can occur when data from several areas of science are integrated into new concepts for theoretical or practical use. Photochemical and Photobiological Reviews continues to provide in depth coverage of the many specialty areas of photobiology. It is hoped that these reviews will provide an important service to the younger scientists in the field and to senior scientists in related fields, because they provide a ready access to the recent literature in the field, and more importantly, they frequently offer a critical evaluation of the direction that the field is taking, or suggest a redirection when appropriate. Since it is important that this review series remain responsive to the needs of photochemists and photobiologists, the Editor would value com ments and suggestions from its readers.

Taschenbuch. Zustand: Neu. Neuware - When Dr. Katherine Tansley's 'Vision in Vertebrates' appeared in 1965, it filled a real void that had hitherto existed. It did so by serving at once as a text-book: for an undergraduate course, a general introduction to the subject for post-graduate students embarking on research on some aspect of vision, and the interested non-specialists. Gordon Walls' 'The Vertebrate Eye and It. s Adaptive Radiation' and A. Rochon-Duvigneaud's 'Les Yeux et la Vision des Vertebres' have served as important sources of information on the subject and continue to do so even though it is 40 years since they appeared. However, they are essentially specialised reference works and are not easily accessible to boot. The genius of Katherine Tansley was to present in a succinct (132 pages) and lucid way a clear and an interesting survey of the matter. Everyone liked it, particularly the students because one could read it quickly and understand it. Thus, when it seemed that a new edition was desirable, especially in view of the enormous strides made and the vast literature that had accumulated in the past 20 years, one of us (MAA) asked Dr. Tansley if she would undertake the task. Since she is in retirement and her health not in a very satisfactory state both she and her son, John Lythgoe (himself a specialist of vision), asked us to take over the task.

Taschenbuch. Zustand: Neu. Neuware - The Conference on Emerging Priorities in Ceramic Engineer ing and Science, held at Alfred University, November 4-6, 1974, was arranged to provide a basis for reassessment of professional goals, procedures and outlook. American priorities among comfort, safety, national prestige, security, convenience and environmental quality are significantly different from those of a dozen years ago. Economic factors have shifted, as exempli fied by scarcities in energy, mate rials and world food supplies. At the same time, demands for safer products, healthier work ing conditions and fairer rules of behavior are making them selves felt. Governmental, corporate and consumer interests are all involved and they are intricately inte rrelated. Higher education, for its part, must not only respond wisely to changing student attitude, itself a part of the national scene, but must gain perspective toward the present and toward changes of yet unknown nature which can be expected in the future. Persistent and pointed questions from engineers, managers, and students were an indication to us of wide-spread concern to understand the new pattern of priorities that is presently emerging. In response to this need, Conference papers were invited from distinguished engineers, scientists, and other specialists; their willingness to contribute from their expertise and their thinking is very much appreciated by the editors. The first four chapters of the volume deal with the larger scene and with the viewpoints of those concerned with it in behalf of government, corporations and the professions.

Taschenbuch. Zustand: Neu. Neuware - Epithelial cells are present in many different tissues in the body, and possess a diverse number of functional properties. However, all epithelial cells share some common characteristics. The cells possess a morphological polarity (an-apical and basolateral surface), and are interconnected by tight junctions. The epithelial cells also possess the capacity to transport select solutes across the monolayer. Transport systems localized on either the apical or basolateral surface are respon sible for this vectorial transport. Such characteristics of epithelial cells can be examined in the tissue culture situation. This volume discusses the use of cell culture techniques to study these fundamental properties of epithelial cells. Ma jor questions concerning epithelia which may be examined in culture are ad dressed. The approaches which are taken to answer these questions are described in detail with regards to kidney cell cultures. Similar investigations may be done with epithelial cell cultures derived from other tissues, following the kidney cell culture paradigm.

Taschenbuch. Zustand: Neu. Neuware - The aim of the editors of this volume is to use basic and ap plied studies in the field of mutagenesis to approach a problem of especial concern. The problem is that of the usage of toxic chemi cals, particularly agricultural chemicals, in ever-increasing quan tities in those parts of the world that feed the most people. Agri cultural chemicals that are in use in Pakistan are emphasized here. These are the same chemicals that are in use throughout the develop ing world, although the quantities of the different types that are used may vary from country to country, and from region to region within countries. A number of these chemicals can no longer be sold in Europe or in the United States, and it is often difficult to iden tify a scientific reason as to why they are sold at all. It is ironic that toxic chemicals are used as a humanitarian device to rid the world of Pestilence and Famine -- two of the Horsemen of the Apocalypse. If we do not wish poisonous chemicals to become the fifth Horseman of the Apocalypse, then we must begin now to identify and regulate the large-scale usage of toxic sub stances everywhere.

Taschenbuch. Zustand: Neu. Neuware - Volume 6 of Cerebral Cortex is in some respects a continuation of Volume 2, which dealt with the functional aspects of cortical neurons from the physiological and pharmacological points of view. In the current volume, chapters are devoted to the catecholamines, which for a number of reasons were not represented in the earlier volume, and to acetylcholine and the neuropeptides, about which much new information has recently appeared. Volume 6 deals in part with the structure and function of cholinergic and catecholaminergic neuronal systems in the cerebral cortex and with new aspects of the cortical peptidergic neurons, notably the almost universal propensity of the known cortical peptides for being colocalized with classical transmitters and with one another. It thus completes our coverage of the major cortical neuro transmitter and neuromodulatory systems. Other chapters in this volume deal with data pertaining to the proportions of different types of cells and synapses in the neocortex and the physiology of the cortical neuroglial cells. These latter are topics that rarely receive separate treatment and the current chapters serve again to continue discussions of subjects that were introduced in Volume 2. The previous volumes have all been devoted to the neocortex but the present one introduces the subject of the archicortex. To this end, separate chapters are devoted to the physiology and anatomy of the hippocampal formation.

Taschenbuch. Zustand: Neu. Neuware - Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.

Taschenbuch. Zustand: Neu. Neuware - Anyone who has any contact with mental patients, old or young, or their families, or just visits a mental hospital or school for the retarded, is aware of the tremendous suffering caused by malfunctioning of the brain. The func tion of no other organ is so crucial for our everyday life, our proper func tioning, indeed our happiness, and no other illness causes as much anguish to patients or their families as mental illness. It is surprising and sad, therefore, how little effort has been devoted to research in this area; more so because such research is the only hope to ameliorate this suffering, or, to speak in the language of politics or economics, to decrease the enormous sums that we spend on trying to help our patients, with what is must generally be agreed are the most primitive and inadequate methods of treatment. Clearly, since functions of the brain are vital not only in illness, but in health, pathology is not the only area of concern to neurochemists, but it is an area that urgently needs neurochemical contributions. Progress in this field has been slower than in other areas of neurochemistry, and it seems that solutions in this field are very elusive. The reason for this is that the experimental approach is especially difficult in conditions specific for humans, or specific for complex behavior.

Taschenbuch. Zustand: Neu. Neuware - Allen I. Laskin Biosciences Research Exxon Research and Engineering Company Linden, New Jersey I was contacted in the Fall of 1981 by Professors Martin Dworkin and Palmer Rogers, of the University of Minnesota and asked to participate in the orgnization of the 1983 conference in the series, 'Interface Between Biology and Medicine'. They and the other members of the advisory committee had the vision to realize that this was a time to depart somewhat from the traditional theme, since one of the major areas of interest in the biological and related sciences these days is that of biotechnology in a broader sense than its impact on medicine alone. In designing the format of the Conference, we considered another factor. There has been a plethora of conferences, symposia, and meetings on biotechnology over the past few years, and the faces and topics have become rather familiar. There has been a strong emphasis on the development of the technology and the 'biotechnology industry'; less attention has been paid to the science behind it. One might get the impression from some of these meetings and from the popular press that biotechnology has just recently sprung up, apparently full blown; the very fundamental scientific discoveries and the great body of 1 ALLEN I. LASKIN 2 continuing research that forms that basis for the technology is often obscured.

Taschenbuch. Zustand: Neu. Neuware - There is no need in the 1970s to explain the writing of a book on 'Environmen tal Chemistry. ' The despoliation of the environment by man's activities has long been clear to chemists. However, it has been the subject of public debate for a short time-since the late 1960s. Curiously, there has been little reaction in the textbook literature to reflect this concern. Apart from some brief and sketchy paperbacks for schools, there has not yet been published a substantial review of environmental chemistry. One reason for this is the breadth of the chemistry involved: it could scarcely be covered by one or two authors, for it is as wide as chemistry itself. The ideal way to write such a book would be to gather a couple of dozen authors in one place and keep them together for 6 months of discussions and writing. This not being very practical, it was decided to do the next best thing and to attempt to network a number of men together in mutual correspondence and interaction, which would lead to a book that had the advantages of the expertise of a large number of persons, and lacked many of the usual disadvan tages of the multi author book. Thus, synopses of the various articles were sent to each author, and they were encouraged to interact with each other in attempting to avoid repetition and in keeping their symbols uniform and their presentation style coordinated.

Taschenbuch. Zustand: Neu. Neuware - The International Thermal Conductivity Conference was started in 1961 with the initiative of Mr. C. F. Lucks and grew out of the needs of researchers in the field. From 1961 to 1973 the Confer ences were held annually, and have been held biennially since 1975 when our Center for Information and Numerical Data Analysis and Synthesis (CINDAS) of Purdue University became the permanent Spon sor of the Conferences. These Conferences provide a broadly based forum for researchers actively working on the thermal conductivity and closely related properties to convene on a regular basis to ex change their ideas and experiences and report their findings and results. The Conferences have been self-perpetuating and are an example of how a technical community with a common purpose can transcend the invisible, artificial barriers between disciplines and gather togeth er in increasing numbers without the need of national publicity and continuing funding support, when they see something worthwi1e going on. It is believed that this series of Conferences not only will grow stronger, but will set an example for researchers in other fields on how to jointly attack their own problem areas.

Taschenbuch. Zustand: Neu. Neuware - Metal ions and proteins are ubiquitous. Therefore, not surprisingly, new protein-metal interactions continue to be dis covered, and their importance is increasingly recognized in both physical and life sciences. Because the subject matter is so broad and affects so many disciplines, in organizing this Symposium, I sought participation of speakers with the broadest possible range of interests. Twenty-two accepted my invitation. To supplement the verbal presentations, the Proceedings include five closely re lated invited contributions. The ideas expressed are those of the various authors and are not necessarily approved or rejected by any agency of the United States Government. No official recommendation concerning the sub ject matter or products discussed is implied in this book. This book encompasses many aspects of this multifaceted field. Topics covered represent biochemical, immunochemical, bioorganic, biophysical, metabolic, nutritional, medical, physiological, toxi cological, environmental, textile, and analytical interests. The discoveries and developments in any of these areas inevitably illumine others. I feel that a main objective of this Symposium, bringing together scientists with widely varied experiences yet with common interests in protein-metal interactions, so that new understanding and new ideas would result has been realized. I hope that the reader enjoys and benefits from reading about the fascinat ing interactions of metal ions and proteins as much as I did.