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Taschenbuch. Zustand: Neu. Neuware - Renal function fails abruptly in a bewildering variety of clinical situations which lack any common clinical patterno This makes it impossible to define acute renal failure in the same way as heart failure or liver failureo Even oliguria, the commonest sign, is not invariably present. As a result, the detection of acute renal failure Table 1. Causes of acute renal failureo Acute tubular necrosis Ischaemic type Nephrotoxic type Cortical necrosi . Hepatorenal syndrome Occlusion of main renal arteries Occlusion of arterioles Malignant hypertension Haemolytic uraemic syndrome Thrombotic thrombocytopenic purpura Postpartum nephrosclerosis Acute glomerulonephritis Post-streptococcal 'Crescentic' nephritis } °do thO °th t ° dO Necrotizing glomerulitis I IOpa IC WI sys emlc Iseases Renal vein thrombosis Obstruction U ric acid crystals Stones Tumours-benign and malignant Fibrosis Strictures 2 Acute and Chronic Renal Failure (ARF) depends on biochemical tests, which are fortunately simple to perform and are commonly available. However, the clinician has to think of the possibility in order to test the diagnosis. Frequently, patients are admitted to a renal unit from medical, surgical or gynaecological wards where the development of ARF has gone unrecognized, either because the relevant investigation has not been performed or because the result has been overlooked. This happens because ARF occurs in patients with complex problems which themselves demand con siderable attention, and it is easy to overlook a comparatively rare, if important, complication.

Taschenbuch. Zustand: Neu. Neuware - During the last 20 years two groups of investigators have concerned themselves with the problem of acid-base regulation at various body temperatures. Each group, in professional isolation, pursued a separate path. Surgeons and anesthe tists developed techniques and tools for hypothermic cardio-pulmonary by-pass operations and based their rationale for acid-base management on in vitro models of blood behavior. Physiologists and biochemists, on the other hand, endeavored to understand acid-base regulation in living organisms naturally subjected to changes in body temperature. Only in the last decade has there been an increasing awareness that each group could benefit from the other's experiences. With this goal in mind members of both groups were invited to present their views and observations in the hope of arriving at a better understanding of acid-base management during hypothermia and gaining a greater insight into the factors which control acid-base regulation during normothermia. This led to the presen tation of the present volume with the aim of providing the clinician with a survey of present theories and the resulting strategies for management of the hypother mic patient. Acknowledgment The editors express their great appreciation to Miss Augusta Dustan for her dedicated effort in the preparation and editing of the manuscripts. Contributors Heinz Becker, M. D. Department of Surgery, University of California Medical Center, Los An geles, Los Angeles, CA 90024, U. S. A. Gerald D. Buckberg, M. D. Department of Surgery, University of California Medical Center, Los An geles, CA 90024, U. S. A.

Taschenbuch. Zustand: Neu. Neuware - The course of history is never one of smooth progression. Periods of relative quietness are interrupted by periods of wars and revolution. This pattern resembles that of a river which, before flowing into the delta, has to pass countless rapids. The same holds for the development of the science of medicine. In obstetrics some of these 'revolutions' or 'rapids' consist of the introduction of conservative obstetrical treatment by Lucas Johann Boer at the beginning of the nineteenth century, the discovery of the cause of puerperal sepsis by Oliver Wendell Holmes and Semmelweiss between 1843 and 1847, the introduction of the principle of asepsis by Pasteur in 1874, the introduction of prenatal care at the end of the nine teenth and the beginning of the twentieth century (Mijnlieff, Treub, De Snoo), the improvement of surgical techniques, the possibility to treat shock by bloodtransfusion, and, finally, the acquisition of new means for the effective therapy of infection. All these developments have led to a sharp reduction of maternal and perinatal mortality. In this connection it must be pointed out that such a reduction could never have been accomplished without the favourable social changes as a result of which medical and prenatal care could be made universally available. In recent years there has been another revolutionary develop ment in obstetrics. Two factors have been responsible for this: the ap plication of basic sciences in obstetrics, and the dissolution of the isolation with respect to other clinical disciplines.

Taschenbuch. Zustand: Neu. Neuware - Many historians have concerned themselves with the founding of the German Empire in 1871 and the means used to unite the disparate sections of Germany, many of which had older traditions than did Bismarck's Prussia. Understandably writers have given more attention to the victor than to the vanquished. Except for polemicists who seek to prove the wrong done or to vindicate the action taken, scholars have been interested in writing about trends which were to become significant in the new Reich, about the new governmental structure itself, and about the diplomacy and statesmanship which were used to form the new German nation-state. But the consolidation of many diverging strands of political, economic, and social traditions in the new state left many issues unsolved and in fact seemed to create new ones. Many of these problems, while not overtly affecting the basic outline of German history, have nonetheless influenced it and have become at times serious matters of concern for the Reich Chancellor. One of the problems was the threat of particularist sentiment to the national unity which Bismarck was trying to create. Although there was an awareness among some nineteenth century Ger mans of a specific German nationality, the majority of people did not think in terms of a German unity but regarded themselves as Bavarians, Saxons, or belonging to some other Stamm, or tribal subdivision of the Germans.

Taschenbuch. Zustand: Neu. Neuware - Automation has been employed for many years to provide a multitude of reasonably priced products for the American consumer. However, it has become evident that its real character as a manufacturing systems approach needs to be examined carefully for a better appreciation. In this book the purpose is to examine automation technology in its broadest sense and develop not only an understanding but also present some of the engineering and organization 'know-how' by which manufacturing management can more effectively utilize automation to improve pro ductivity and combat rising costs in the years ahead. Fundamentally, this book is addressed to manufacturing managers, and the material presented in a manner that will provide the knowledge for assuring success in automating. In addition, it highlights the man ufacturing research and long-range planning that will be required for creating the new manufacturing technology so necessary for assuring success in future automation efforts. One of the important facts emphasized in this text is that automation is not merely robotics ar another kind or type of machinery. To effect true productivity improvement requires a fresh look at the entire pro duction process or facility-as a completely integrated system. With the developments of the past few years, rapid advances in the technology and the 'tools of automation' have brought this imperative goal within the reasonable grasp of manufacturing management in almost every segment of industry. However, to utilize this progress, it is necessary to acquire a working understanding of all facets of automation.

Taschenbuch. Zustand: Neu. Neuware - DR. R. E. SMITH The first and second Coventry conferences on 'Surgery of the Oesophagus' and 'Surgery of the Lung' were arranged by Mr. Roger Abbey Smith, and they were so successful that he asked his colleague, Mr. J. A. Dyde to arrange one on 'Surgery of the Heart.' He willingly accepted this task and has also been joint Editor. This book reproduces as faithfully as possible the papers and the discussion on the various subjects included in the Coventry conference. The simple title 'Surgery of the Heart' could be expanded to include the blood vessels. Especially important is the anatomy of the various combinations and permutations of the pulmonary and systemic vessels. These playa major role in the production of pulmonary hypertension. First class investigations by radiologists, and physiologists ascertain the precise situation which the surgeon will expect to find when he opens the chest; indeed will help him to make the right approach. Mr. W. G. Williams helped with the social programme which enabled people to meet people. Mr. A. Martin gave us valuable help in taping the recordings which Mrs. J. Jelley and Mrs. V. Bayliss-Stranks ably transcribed. The editorial staff of Plenum Publications have given us unsparing advice and guidance. v PROLOGUE DR. R. E. SMITH I welcome you all to this conference on Surgery of the Heart.

Taschenbuch. Zustand: Neu. Neuware - The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renaL cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series, Advances in Eicosanoid Research, reflects the current understanding of prostaglandins, thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr Michael Brewis and the staff at MTP Press.

Taschenbuch. Zustand: Neu. Neuware.

Taschenbuch. Zustand: Neu. Neuware - The importance of international liner shipping needs little emphasizing. A large majority of international trade moves by sea, and the liner shipping share in total freight revenue exceeds one-half. Notwithstanding, people in general know surprisingly little about the basic facts of the liner shipping industry, and, in particular, about the economics ofliner shipping. Perhaps because it is an international industry, where shipping lines flying many different flags participate, it has tended to fall in between national accounts of domestic industries. Even transport economists have, generally speaking, treated liner shipping rather 'stepmotherly'; besides the work of Bennathan and Walters (1969), a relatively small group of specialized maritime economists, including A. Stromme-Svendsen, T. Thorburn, S. Sturmey, R. Goss, and B. M. Deakin, have in the post-war period made important contributions to the subject, but so far no coherent and reasonably comprehensive treatise of liner shipping economics has appeared. The first purpose of the present volume is therefore obvious: to provide just that. The book is divided in three parts: Part I The liner shipping industry; Part II Liner service optimization; Part III Economic evaluation of the conference system. Needless to say, all three parts concur to fulfill the first purpose of providing a complete book of liner shipping economics. In Part II a more or less separate, second, purpose has been to develop analytical tools for liner service optimization. Thereby we use different approaches.

Taschenbuch. Zustand: Neu. Neuware - What shall we say of this metamorphosis in passing from finite to infinite Galileo, Two New Sciences As its title suggests, this book was conceived as a prologue to the study of 'Why the calculus works'--otherwise known as analysis. It is in fact a critical reexamination of the infinite processes arising in elementary math ematics: Part II reexamines rational and irrational numbers, and their representation as infinite decimals; Part III examines our ideas of length, area, and volume; and Part IV examines the evolution of the modern function-concept. The book may be used in a number of ways: firstly, as a genuine pro logue to analysis; secondly, as a supplementary text within an analysis course, providing a source of elementary motivation, background and ex amples; thirdly, as a kind of postscript to elementary analysis-as in a senior undergraduate course designed to reinforce students' understanding of elementary analysis and of elementary mathematics by considering the mathematical and historical connections between them. But the contents of the book should be of interest to a much wider audience than this including teachers, teachers in training, students in their last year at school, and others interested in mathematics.

Taschenbuch. Zustand: Neu. Neuware - The design and assessment of modern high temperature plant demands an understanding of the creep and rupture behaviour of materials under multi axial stress states. Examples include thread roots in steam turbine casing bolts, branch connections in nuclear pressure vessels and blade root fixings in gas or steam turbine rotors. At one extreme the simple notch weakening/notch strengthening characterization of the material by circumferentially vee-notched uniaxial rupture tests, as specified in many national standards, may be sufficient. These were originally intended to model thread roots and their conservatism is such that they frequently are considered adequate for design purposes. At the other extreme full size or model component tests may be employed to determine the safety margins built into design codes. This latter approach is most commonly used for internally pressurized components, particularly where welds are involved. However, such tests are extremely expensive and the use of modern stress analysis techniques combined with a detailed knowledge of multiaxial properties offers a more economic alternative. Design codes, by their nature, must ensure conservatism and are based on a material's minimum specified properties. In the case of high temperature components the extension of life beyond the nominal design figure, say from 100000 to 200000 h, offers very significant economic benefits. However, this may require a more detailed understanding of the multiaxial behaviour of a specific material than was available at the design stage.

Taschenbuch. Zustand: Neu. Neuware - Technology transfer has a long history, but only recently has it become the subject of study and action. The rapid rate of scientific and technical advance in both Europe and the United States and the existence of large technology gaps among nations has brought the importance of the process into sharper focus, and has c~used technology transfer to have implications for countless aspects of both national and international develop ment. Technology transfer has been variously defined as: the process of information transfer between science, technology and actual utilization of scientific data and ideas, to wit: production of goods and services; the process by which science and technology are diffused throughout human activity; the transfer of research results into operations; the process by which technical information originating in one setting is adapted for use in another setting. Collectively, these and other definitions share a common theme which characterizes the process as one of bringing technology i'ilto widespread use in solving mankind's problems in the shortest practical time. The first NATO Advanced Study Institute (ASI) on Technology Transfer in July, 1973, brought together many of the individuals dealing with quantitative data, based on empirical research. This conference had both the advantages and disadvantages of a somewhat detached point of view. The ASI also had lectures contributed by representatives from government agencies and corporations (and a few university-based scholars) who had been active as practitioners or consultants in policy-making and organizational design for technology transfer.

Taschenbuch. Zustand: Neu. Neuware - In recent years, a great deal has been written on the topic of aggression; another book on the same topic might seem superfluous at this time. However, the present volume is not just-or even primarily-about aggres sion. It is, rather, a book on anger. Anger and aggression are closely related phenomena, and it is not possible to discuss one without the other. Yet, not all anger is aggressive, nor can all aggression be attributed to anger. Therefore, somewhat different considerations apply to each. Even more importantly, the type of theoretical generalizations one can make differs depending upon whether the primary focus is on anger or aggression. The present volume is subtitled 'an essay on emotion.' This indicates that the generalizations to be drawn have more to do with emotional responses (e.g., grief, love, envy, etc.) than with various forms of aggression (e.g., riots, war, crimes of violence, etc.). Stated somewhat differently, anger is here being used as a paradigm case for the study of emotion, not for the study of aggression.

Taschenbuch. Zustand: Neu. Neuware - This book is intended to present group representation theory at a level accessible to mature undergraduate students and beginning graduate students. This is achieved by mainly keeping the required background to the level of undergraduate linear algebra, group theory and very basic ring theory. Module theory and Wedderburn theory, as well as tensor products, are deliberately avoided. Instead, we take an approach based on discrete Fourier Analysis. Applications to the spectral theory of graphs are given to help the student appreciate the usefulness of the subject. A number of exercises are included. This book is intended for a 3rd/4th undergraduate course or an introductory graduate course on group representation theory. However, it can also be used as a reference for workers in all areas of mathematics and statistics.

Taschenbuch. Zustand: Neu. Neuware -In recent years, many students have been introduced to topology in high school mathematics. Having met the Mobius band, the seven bridges of Konigsberg, Euler's polyhedron formula, and knots, the student is led to expect that these picturesque ideas will come to full flower in university topology courses. What a disappointment 'undergraduate topology' proves to be! In most institutions it is either a service course for analysts, on abstract spaces, or else an introduction to homological algebra in which the only geometric activity is the completion of commutative diagrams. Pictures are kept to a minimum, and at the end the student still does nr~ understand the simplest topological facts, such as the rcason why knots exist. In my opinion, a well-balanced introduction to topology should stress its intuitive geometric aspect, while admitting the legitimate interest that analysts and algebraists have in the subject. At any rate, this is the aim of the present book. In support of this view, I have followed the historical development where practicable, since it clearly shows the influence of geometric thought at all stages. This is not to claim that topology received its main impetus from geometric recreations like the seven bridges; rather, it resulted from the l'isualization of problems from other parts of mathematics-complex analysis (Riemann), mechanics (Poincare), and group theory (Dehn). It is these connec tions to other parts of mathematics which make topology an important as well as a beautiful subject.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 352 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - In recent years, many students have been introduced to topology in high school mathematics. Having met the Mobius band, the seven bridges of Konigsberg, Euler's polyhedron formula, and knots, the student is led to expect that these picturesque ideas will come to full flower in university topology courses. What a disappointment 'undergraduate topology' proves to be! In most institutions it is either a service course for analysts, on abstract spaces, or else an introduction to homological algebra in which the only geometric activity is the completion of commutative diagrams. Pictures are kept to a minimum, and at the end the student still does nr~ understand the simplest topological facts, such as the rcason why knots exist. In my opinion, a well-balanced introduction to topology should stress its intuitive geometric aspect, while admitting the legitimate interest that analysts and algebraists have in the subject. At any rate, this is the aim of the present book. In support of this view, I have followed the historical development where practicable, since it clearly shows the influence of geometric thought at all stages. This is not to claim that topology received its main impetus from geometric recreations like the seven bridges; rather, it resulted from the l'isualization of problems from other parts of mathematics-complex analysis (Riemann), mechanics (Poincare), and group theory (Dehn). It is these connec tions to other parts of mathematics which make topology an important as well as a beautiful subject.

Taschenbuch. Zustand: Neu. Neuware - Because of increasing worldwide interest in the subject, a decision was made to coordinate the papers presented at the First European Symposium on Hysteroscopy, held in Antwerp, Belgium, in September 1982, into a text on hysteroscopy, including its indications, techniques, and complications. The Organising Committee called on Dr. Louis G. Keith of Northwestern University, Chicago, illinois USA, to edit all of the papers and to prepare them for publication as a multi-author textbook rather than as a haphazard collection of the proceedings of a meeting. Dr. Keith also supervised the many details of preparing the manuscript for publication, including the task of copy editing. The speakers at the Symposium were all eminent European hysteroscopists; the most up-to-date information was presented, assuring the current nature of the scientific data. By way of introduction (Part I), a historical survey of the development of hysteroscopy is presented. The material is then divided into several parts. Part II concerns the technical aspects of hysteroscopy. Part m includes the different clinical applications of hysteroscopy. Part IV concerns special applications of hysteroscopy, and the Conclusion (Part V) contains the remarks of two distinguished American guests. Dr. Alvin M. Siegler presented a special lecture on Jan Palfijn (Chapter 29), and Dr. Louis G. Keith was asked to discuss the relationship between art and medicine at a banquet at the Rubens Mansion in Antwerp (Chapter 30).

Taschenbuch. Zustand: Neu. Neuware - of Part 2.- 1 Natural family planning.- 2 Barrier methods of contraception.- 3 Chemistry, contraceptive activity and toxicology of aryl guanidinobenzoates: inhibitors of sperm acrosin.- 4 Measurement of LH in saliva: a new approach to ovulation detection.- 5 Steroid-induced side-effects of oral contraceptives.- 6 Efficacy and physiology of a triphasic oral contraceptive.- 7 Advantages and disadvantages of low-dose hormonal contraceptive agents.- 8 Emerging routes of delivery for fertility-control agents.- 9 Current status of NORPLANT subdermal implants for contraception.- 10 New aspects in post-coital contraception.- 11 Biological evaluation of some medicinal plant extracts for contraceptive efficacy in females.- 12 Pharmacokinetic and antigenicity studies with LHRH analogues.- 13 LHRH nasal spray in contraception.- 14 Acute and intermittent LHRH agonist dosing as post-coital and anti-ovulatory contraceptive approaches.- 15 LHRH antagonists and contraception.- 16 Mechanism of action of gonadotrophin releasing hormone in the pituitary and gonads.- 17 Morphological changes on the surface of IUDs: are they of clinical significance .- 18 The use of non-culture tests for the detection of VD prior to IUD insertion: a view towards the future.- 19 Experience with GYNE-T Cu-380-A intrauterine contraceptive device (1981-1984).- 20 Ten years' experience with continuous use of the butterfly IUD.- 21 The antiprogesterone activity of RU 486, a contragestive agent in the human.- 22 Effects of the anti progesterone RU 486 in early pregnancy and during the menstrual cycle.- 23 Prostaglandins in contraception.- 24 Ovarian hormones and cybernins.- 25 Biochemical aspects of a contraception model based on immunological properties of proteohormones.- 26 Variability in antisperm andantiembryonic humoral immune responses.- 27 Research for the development of an hCG antifertility vaccine.- 28 Present and future aspects of immunological methods in contraception.- 29 Preclinical and clinical aspects of safety in contraception.- 30 The politics of contraception.- 31 Contraceptive futurology: or 1984 in 1984.

Taschenbuch. Zustand: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in food stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any seriou~ question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, toxicologists, and changing pest-control requfrements in progressive food-producing economies. These matters are of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals per sisting into our foodstuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and tOXicological disciplines.

Taschenbuch. Zustand: Neu. Neuware - Worldwide concern in scientific, industrial, and governmental com munities over traces of toxic chemicals in foodstuHs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other eyaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.

Taschenbuch. Zustand: Neu. Neuware - Worldwide concern in scientific, indus hi aI, and governmental com munities over traces of toxic chemicals in foodstuffs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.

Taschenbuch. Zustand: Neu. Neuware - Worldwide concern in scientific, industrial, and governmental com munities over traces of toxic chemicals in foodstuffs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important by this emerging area of science together with world literature produced documentation of pertinent ancillary legislation.

Taschenbuch. Zustand: Neu. Neuware - A specialist in hand surgery will not be available at all hospitals for some years. In the meantime, the fate of the patient will continue to rest in the hands of the surgeon who first treats him. It is essential, therefore, that both the novice and the accomplished surgeon have a sound grasp of the diagnostic and therapeutic fundamentals of hand surgery. The material in this book is presented in a clear, practical manner by a general surgeon who has successfully practiced hand surgery; the result is an especially useful and rewarding book. Many acute situations in hand surgery are not as complicated as they appear to be, whereas other problems can be handled only after much study and experience. Based on his experience with over 7000 general and emergency opera- tions yearly at the Ludwigshafen Surgical Clinic and after years of inten- sive work in the field of hand surgery, my medical chief, Dr. H. R. Mittelbach, has taken the time and trouble to write this handbook for general and clinical practice. For the practicing surgeon and especially the resident, the most important aspects of the treatment of hand injuries have been presented in a clear, concise manner. The didactic excellence of the material, its novel format, and the simple yet forceful drawings that obviate lengthy text descriptions enable the reader to become quickly oriented. However, the book is more thanjust a 'cookbook' for quick reference.

Taschenbuch. Zustand: Neu. Neuware - A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means . can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that 'All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison', and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.

Taschenbuch. Zustand: Neu. Neuware - Approach your problem from the right It isn't that they can't see end and begin with the answers. the solution. Then one day, perhaps you will find It is that they can't see the the final question. problem. G.K. Chesterton. The Scandal The Hermit Clad in Crane Feathers in of Father Brown The Point of R. van Gulik's The Chinese Maze Murders. a Pin. Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the 'tree' of knowledge of mathematics and related fields does not grow only by putting forth new brancheq. It also happens, quite often in fact, that branches which were thought to be completely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics, algebraic geometry interacts with physics; the Minkowsky lemma, coding theory and the structure of water meet one another in packing and covering theory; quantum fields, crystal defects and mathematical programming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces. And in addition to this there are such new emerging subdisci fI plines as 'experimental mathematics', 'CFD , 'completely integrable systems', 'chaos, synergetics and large-scale order', which are almost impossible to fit into the existing classification schemes.

Taschenbuch. Zustand: Neu. Neuware - The Sources and Nature of the Statistics of the United Kingdom, produced under th~ auspices of the Royal Statistical Society and edited by Maurice Kendall, filled a notable gap on the library shelves when it made its appearance in the early post-war years. Through a series of critical reviews by many of the foremost national experts, it constituted a valuable contemporary guide to statisticians working in many fields as well as a bench-mark to which historians of the development of Statistics in this country are likely to return again and again. The Social Science Research Council\* and the Society were both delighted when Professor Maunder came forward with the proposal that a revised version should be produced, indicating as well his willingness to take on the onerous task of editor. The two bodies were more than happy to act as co-sponsors of the project and to help in its planning through a joint steering committee. The result, we are confident, will be judged a worthy successor to the previous volumes by the very much larger 'statistics public' that has come into being in the intervening years. Mrs SUZANNE REEVE Mrs E. J. SNELL Secretary Honorary Secretary Economic and Social Research Council Royal Statistical Society \*SSRC is now the Economic and Social Research Council (ESRC). vii MEMBERSHIP OF JOINT STEERING COMMITTEE (December 1986) Chairman: Miss S. V. Cunliffe Representing the Royal Statistical Society: Mr M. C. Fessey Dr S. Rosenbaum Mrs E. J.

Taschenbuch. Zustand: Neu. Neuware - The publication of this volume, which is based upon presentations made to the Third European Symposium on Radiopharmacology at Noordwijkerhout, April 22 - 24, 1982, is indicative of the continued interest in this sub-branch of Nuclear Medicine. The transactions of the first two meetings were published as Progress in Radiopharmacology, Volumes 1 and 2 by Elsevier/North-Holland Bio medical Press. We are particularly pleased to have reached an agreement with Martinus Nijhoff Publishers to include Progress in Radiopharmacology 3 in the series Developments in Nuclear Medicine. This not only ensures the continuity of the series but by including it in a series of Nuclear Medical Monographs the availability of the text to more general readers, for background information, is greatly enhanced. As with the previous two volumes each of the three topics has been so treated as to relate the biodistribution of the radiopharmaceuticals to normal and pathophysiological conditions to provide background information for the practising nuclear medical specialist. Special attention has been given to European activities but these have been clearly placed in context in relation to developments from outside Europe. The Third European Symposium on Radiopharmacology was held under the auspices of the European Joint Commitee on Radiopharmaceuticals of the European Nuclear Medicine Society and the Society of Nuclear Medicine Europe. Solco Nuclear, Basle, provided both financial and material support and I would like to thank Dr M. de Schrijver, Mr. I. Waser and Mrs. E. Rufenacht for their continued help and encouragement.

Taschenbuch. Zustand: Neu. Neuware - Approach your problems from It isn't that they can't see the right end and begin with the solution. the answers. Then one day, It is that they can't see the perhaps you will find the problem. final question. G.K. Chesterton. The Scandal 'The Hermit Clad 1n Crane of Father Brown 'The Point of Feathers' in R. van Gulik's a Pin'. The Chinese Maze Murders. Growing specialisation and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the 'tree' of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches wich were thought to be completely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, coding theory and the structure of water meet one another in packing and covering theory; quantum fields, crystal defects and mathematical programming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces. And in addition to this there are such new emerging subdisciplines as 'experimental mathematics', 'CFD' , 'completely integrable systems', 'chaos, synergetics and large-scale order', which are almost impossible to fit into the existing classification schemes. They draw upon widely different sections of mathematics.

Taschenbuch. Zustand: Neu. Neuware - Evolutionary Biology, of which this is the twenty-second volume, continues to offer its readers a wide range of original articles, reviews, and commentaries on evolution, in the broadest sense of that term. The topics of the reviews range from anthropology, molecular evolution, and paleobiology to principles of systematics. In recent volumes, a broad spectrum of articles have appeared on such subjects as asymmetric sexual isolation, biochemical systematics in plants, species selection, DNA hybridization and phylogenetics, modes of evolution in Pleistocene rodents, and development and evolution of the vertebrate limb. We have also attempted to provide a forum for con flicting ideas. Articles such as these, often too long for standard journals, are the material for Evolutionary Biology. The editors continue to solicit manuscripts on an international scale in an effort to see that everyone ofthe many facets of biological evolution is covered. Manuscripts should be sent to anyone of the following: Max K. Hecht, Department of Biology, Queens College of the City University of New York, Flushing, New York 11367; Bruce Wallace, Department of Biology, Virginia Polytechnic Institute and State University, Blacks burg, Virginia 24061; GhilleanT. Prance, New York Botanical Garden, Bronx, New York 10458. The Editors vii Contents 1. Phylogeny of Early Vertebrate Skeletal Induction and Ossification Patterns . 1 John G. Maisey Introduction: The Fossil Record. . . . . . . . . . . . . . . . 1 .

Taschenbuch. Zustand: Neu. Neuware - Worldwide concern in scientific, industrial, al,ld governmental com munities over traces of toxic chemicals in foodstuHs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.