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Taschenbuch. Zustand: Neu. Neuware - The theme of this volume--risk analysis in the private sector--reflects a changing emphasis in risk analysis. Until re cently, attention has been focused on risk analyses conducted in support of federal regulatory decision making. Such analyses have been used to help set safety standards, to illuminate issues of regulatory concern, and to evaluate regulatory alternatives. As this volume indicates, however, risk analysis encompasses a broader set of activities. Analyses performed by private sector institutions aimed at preventing or reducing potential adverse health or environmental effects also play an important part in societal risk management. In virtually all societies, there have been strong incentives for the private sector to conduct such analyses. These incentives range from moral or altruistic norms and values to simple self-interest based on fear of monetary loss, possible civil or criminal litigation, or punitive or restrictive government action. The papers in this volume address the overall theme from a variety of perspectives. Specifically, the papers represent con tributions from such diverse fields as toxicology, epidemiology, chemistry, biology, engineering, statistics, decision analysis, economics, psychology, philosophy, and the law.

Taschenbuch. Zustand: Neu. Neuware.

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Taschenbuch. Zustand: Neu. Neuware.

Taschenbuch. Zustand: Neu. Neuware.

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Taschenbuch. Zustand: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in foodstuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the individuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being displaced by newly deve10ped ones more acceptable to food technologists, pharma cologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are also of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals persisting into our food stuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technologieal, medical, pharmacological, and toxicological disciplines.

Taschenbuch. Zustand: Neu. Neuware - That residues of pestidde and other 'foreign' chemicals in foodstufts are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying en thusiasm, sincerity, and effons shown by all the individuals from whom manuscripts have been solidted. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that pers ist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being displaced by newly developed ones more acceptable to food technologists, pharma cologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are also of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals persisting into our food stuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemi cal, food technological, medical, pharmacological, and toxicological dis ciplines.

Taschenbuch. Zustand: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in foodstuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying en thusiasm, sincerity, and efforts shown by all the individuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being displaced by newly developed ones more acceptable to food technologists, pharma cologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are also of genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these chemicals persisting into our food stuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemi cal, food technological, medical, pharmacological, and toxicological dis ciplines.

Taschenbuch. Zustand: Neu. Neuware - That residues of pesticide and other 'foreign' chemicals in food stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, tOxicolOgists, and changing pest-control requirements in progressive food-prodUCing economies. These matters are of' genuine concern to increasing numbers of governmental agencies and legislative bodies around the world, for some of these chemicals have resulted in a few mishaps from improper use. Adequate safety-in-use evaluations of any of these -chemicals per sisting 'into our foodstuffs are not simple matters, and they incorporate the considered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and tOXicological disciplines.

Taschenbuch. Zustand: Neu. Neuware -In the strange world of quantum mechanics the application of visualization techniques is particularly rewarding, for it allows us to depict phenomena that cannot be seen by any other means. Visual Quantum Mechanics relies heavily on visualization as a tool for mediating knowledge. The book comes TM with a CD-ROM containing about 320 digital movies in QuickTime f- mat, which can be watched on every multimedia-capable computer. These computer-generated animations are used to introduce, motivate, and ill- trate the concepts of quantum mechanics that are explained in the book. If a picture is worth a thousand words, then my hope is that each short animation (consisting of about a hundred frames) will be worth a hundred thousand words. The collection of lms on the CD-ROM is presented in an interactive en- TM vironmentthathasbeendevelopedwiththehelpofMacromediaDirector . This multimedia presentation can be used like an adventure game without special computer skills. I hope that this presentation format will attract the interest of a wider audience to the beautiful theory of quantum mechanics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - Advances in Nutritional Research was conceived by the Public and Professional Information Committee of the American Institute of Nutrition as a service to the membership of the Institute and to others engaged in research and teaching in the nutritional sciences. This publication, which will consist of a series of annual volumes, is in tended to serve primarily as a source of authoritative information on the status of research on topics of active current investigation. In addition, it will contain reviews on subjects of research that have been characterized by progressive, if unspectacular, developments over a period of years. The coverage will extend to basic research in human, animal, and microbial nutrition, nutritional biochemis try, clinical nutrition, nutritional toxicology and pathology, and related specialties. The editors hope that this series will assist investigators to keep abreast of new developments in the broad field of nutritional research. It should be 'of particular value to graduate students and to investigators who wish to acquire a grasp of the current state of knowledge in fields other than their own. If the response of authors of the chapters in this first volume and the quality of their contributions are indicative, this hope will be realized. H. H. Draper Chairman, Board of Editors vii Contents Chapter 1 Role of Vitamin K in the Synthesis of Clotting Factors. . . 1 1. W. Suttie 1. Historical Background . .

Taschenbuch. Zustand: Neu. Neuware - The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.

Taschenbuch. Zustand: Neu. Neuware - In the strange world of quantum mechanics the application of visualization techniques is particularly rewarding, for it allows us to depict phenomena that cannot be seen by any other means. Visual Quantum Mechanics relies heavily on visualization as a tool for mediating knowledge. The book comes TM with a CD-ROM containing about 320 digital movies in QuickTime f- mat, which can be watched on every multimedia-capable computer. These computer-generated animations are used to introduce, motivate, and ill- trate the concepts of quantum mechanics that are explained in the book. If a picture is worth a thousand words, then my hope is that each short animation (consisting of about a hundred frames) will be worth a hundred thousand words. The collection of lms on the CD-ROM is presented in an interactive en- TM vironmentthathasbeendevelopedwiththehelpofMacromediaDirector . This multimedia presentation can be used like an adventure game without special computer skills. I hope that this presentation format will attract the interest of a wider audience to the beautiful theory of quantum mechanics.

Taschenbuch. Zustand: Neu. Neuware -The theme of this volume--risk analysis in the private sector--reflects a changing emphasis in risk analysis. Until re cently, attention has been focused on risk analyses conducted in support of federal regulatory decision making. Such analyses have been used to help set safety standards, to illuminate issues of regulatory concern, and to evaluate regulatory alternatives. As this volume indicates, however, risk analysis encompasses a broader set of activities. Analyses performed by private sector institutions aimed at preventing or reducing potential adverse health or environmental effects also play an important part in societal risk management. In virtually all societies, there have been strong incentives for the private sector to conduct such analyses. These incentives range from moral or altruistic norms and values to simple self-interest based on fear of monetary loss, possible civil or criminal litigation, or punitive or restrictive government action. The papers in this volume address the overall theme from a variety of perspectives. Specifically, the papers represent con tributions from such diverse fields as toxicology, epidemiology, chemistry, biology, engineering, statistics, decision analysis, economics, psychology, philosophy, and the law. 520 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - Worldwide concern in scientific, industrial, and governmental com munities over traces of toxic chemicals in foodstuffs and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to provide in international communication the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmentaI contamination and toxicology. Until now there has been no journal or other publication series reserved exclusively for the diversified literature on 'toxic' chemicals in our foods, our feeds, our geographical surroundings, our domestic animals, our wild life, and ourselves. Around the world immense efforts and many talents have been mobilized to technical and other evaluations of natures, locales, magnitudes, fates, and toxicology of the persisting residues of these chemicals loosed upon the world. Among the sequelae of this broad new emphasis has been an inescapable need for an articulated set of authorita tive publications where one could expect to find the latest important world literature produced by this emerging area of science together with documentation of pertinent ancillary legislation.

Taschenbuch. Zustand: Neu. Neuware - This volume is the fourth in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is devoted to a de scription of depressive illness from a variety of perspectives that include that of the patient, the clinician, and the psychiatric researcher. It de scribes the major subtypes of depressive illness and places them in the context of the life cycle. The second volume in this series is entitled Models of Depres sive Disorders: Psychological, Biological, and Genetic Perspectives. This volume describes several major models of depressive disorders, in cluding genetic, cognitive, interpersonal, intrapsychic, and neurobio logical models. The third and fourth volumes deal with the biology of affective disorders in detail. These volumes are distinguished by a triaxial ap proach. In Volume III the biology of affective disorders is described from the perspective of individual transmitter systems and neurophysio logic and biologic processes. In Volume IV the biology of depression is addressed from the vantage point of symptom components of de pression, and similarities and differences in the biology of depression are described compared to other psychiatric disorders with clini cally overlapping features such as anxiety disorders or eating disor ders. The effects on biology of comorbid conditions such as anxiety, personality disorders, alcoholism, and eating disorders are reviewed.

Taschenbuch. Zustand: Neu. Neuware - That residues of pesticide and other contaminants in the total environment are of concern to everyone everywhere is attested by the reception accorded previous volumes of 'Residue Reviews' and by the gratifying enthusiasm, sincerity, and efforts shown by all the in dividuals from whom manuscripts have been solicited. Despite much propaganda to the contrary, there can never be any serious question that pest-control chemicals and food-additive chemicals are essential to adequate food production, manufacture, marketing, and storage, yet without continuing surveillance and intelligent control some of those that persist in our foodstuffs could at times conceivably endanger the public health. Ensuring safety-in-use of these many chemicals is a dynamic challenge, for established ones are continually being dis placed by newly developed ones more acceptable to food tech nologists, pharmacologists, toxicologists, and changing pest-control requirements in progressive food-producing economies. These matters are of genuine concern to increasing numbers of governmental agencies and legislative bodies around the' wprld, for some of these chemicals have resulted in a few mishilps from improper use. Adequate safety-in-use evaluations of any of these chemicals per sisting into our foodstuHs are not simple matters, and they incorporate theconsidered judgments of many individuals highly trained in a variety of complex biological, chemical, food technological, medical, pharmacological, and toxicological disciplines.

Taschenbuch. Zustand: Neu. Neuware - Artificial Intelligence is entering the mainstream of com puter applications and as techniques are developed and integrated into a wide variety of areas they are beginning to tax the pro cessing power of conventional architectures. To meet this demand, specialized architectures providing support for the unique features of symbolic processing languages are emerging. The goal of the research presented here is to show that an archi tecture specialized for Prolog can achieve a ten-fold improve ment in performance over conventional, general-purpose architec tures. This book presents such an architecture for high perfor mance execution of Prolog programs. The architecture is based on the abstract machine descrip tion introduced by David H.D. Warren known as the Warren Abstract Machine (W AM). The execution model of the W AM is described and extended to provide a complete Instruction Set Architecture (lSA) for Prolog known as the PLM. This ISA is then realized in a microarchitecture and finally in a hardware design. The work described here represents one of the first efforts to implement the W AM model in hardware. The approach taken is that of direct implementation of the high level WAM instruction set in hardware resulting in a elSe style archi tecture.

Taschenbuch. Zustand: Neu. Neuware -Instructors, students and researchers interested in better understanding quantum mechanical principles and concepts through 'Visual Quantum Mechanics.' It is the first book withonline materials on SpringerExtrasto take a comprehensive scientific visualization techniques approach to the subject. 316 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - The emergence of a new scientific book series requires some explanation regarding how it hopes to compensate the reader for the discomforts it undoubtedly produces both in the realms of informational input-overload and in the financial strain on personal and institutional budgets. This series recognizes that investigators who have entered neurochemistry from the biochemical tradition have a rather specialized view of the brain. Too often, interdisciplinary offerings are initially attractive but turn out to recite basic biochemical considerations. We have come to believe that there are now sufficiently large numbers of neurochemists to support a specialized venture such as the present one. We have begun with consideration of traditional areas of neurochemistry which show considerable scientific activity. We hope they will serve the neurochemist both for general reading and for specialized information. The reader will also have the opportunity to reftect on the unbridled speculation that results from the disinhibiting effects on the author who has been invited to write a chapter. We plan occasionally also to offer reviews of areas not completely in the domain of neurochemistry which we nevertheless feel to be sufficiently timely to be called to the attention of all who use chemical principles and tools in an effort to better understand the brain. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 POSSIBLE ROLES OF PROSTAGLANDINS IN THE NERVOUS SYSTEM LEONHARD S. WOLFE 1. Introduction 1 1. 1. Background 1 Names and Structures 1. 2. 4 1. 3. Biosynthesis 4 1. 4.

Taschenbuch. Zustand: Neu. Neuware - All around us, in this age of consumerism, are expressions of public expectations regarding the quality of medical care. Among the responses of the medical profession to this growing public demand has been a cre scendo of interest in continuing education. Continuing education is not a new concern for the physician. Most major professional organizations were founded to increase the exchange of information among members. But something new is in the wind. Both inside and outside the profes sion, the question is becoming more and more insistent: What does at tendance at meetings or exposure to other types of prepared materials have to do with the quality of care that is provided Recertification, reexamination, and peer review of outcomes of practice-subjects only recently unmentionable-have become common issues before specialty boards, legislatures, hospital boards, insurance carriers, and even medical societies. As of October of 1979, all 22 of the member boards of the American Board of Medical Specialties had made commitments to the principle of periodic recertification of their members. Most boards have explicitly acknowledged that the cognitive skills measured in the objective examination do not assure clinical competence. An assumption behind information-assessing recertification efforts is that, though mastery of the current knowledge upon which clinical decisions should be made does not guarantee competent practice, the lack of it probably impairs competent practice.

Taschenbuch. Zustand: Neu. Neuware - The chapters of this book were prepared as task force reports under the aegis of the Biofeedback Society of America (BSA). The impetus for the present generation of task force reports can be dated back to 1982, when John D. Rugh, as President-Elect of the Society, announced that the updating of the task force reports would be given high priority during his term as President. An ad hoc Task Force Committee was appointed in 1983, and the committee set the following objectives: (1) solicit a widely based stream of input from all segments of the Biofeedback Society of America, (2) establish a peer review system to assure the highest degree of scholarship and an unbiased approach, (3) select for area authors only individuals who have profound knowledge of the area and who have demonstrated the ability to extend understanding by reviewing and criticizing the literature, (4) prepare all reports according to a standard ized format, and (5) publish all the reports simultaneously. Input came from several sources. Many people responded with ideas and suggestions to an announcement in the BSA Newsletter that the task force reports were being revised. In 1984, a symposium was conducted at the BSA annual meeting, which included round table dis cussions and dialogues between task force report authors and the BSA membership.

Taschenbuch. Zustand: Neu. Neuware - As in any field of clinical or scientific endeavor, a cataloguing of the techniques and findings of behavioral pediatrics must follow shortly after the first few years of systematic work. This book has been designed to serve this initial summary function for the field. It represents a first attempt to bring together in one place the definition and scope of be havioral pediatrics and to outline current research and treatment ap proaches to various organic disorders, clinical settings, and problem areas in which a sufficient body of knowledge has accrued for author itative statement. As the first text in a rapidly expanding area, our decisions regarding the topics to be covered and the contributors to this volume were guided by our desire to represent what we would consider to exemplify the field in its early development: pragmatic and thorough study of signif icant problems from a base of sound scientific inquiry. Each of the topics addressed in the present volume develops, in a preliminary fashion, an epistemology for current practice and future study. All of the contrib uting authors have been involved in the development of their specialty areas through their research and, importantly, through their clinical work in the hospitals affiliated with the medical schools in which they hold appointments.