springer sep 2016 (58 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware -Protein Design: Method and Applications, Second Editionexpands upon the previous edition with current, detailed ideas on how to approach a potential protein design project. With new chapters onmetals as structure-forming elements and functional sites, the design and characterization of fluorinated proteins, top-down symmetric deconstruction and the design of protein libraries and novel or repurposed enzymes.Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and intuitive,Protein Design: Method and Applications, Second Editionprovides a number of practical protocols and instructive reviews to aid in the creation of new experiments.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 292 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - This report presents the Round-Robin (RR) program and test results including a statistical evaluation of the RILEM TC195-DTD committee named 'Recommendation for test methods for autogenous deformation (AD) and thermal dilation (TD) of early age concrete'. The task of the committee was to investigate the linear test set-up for AD and TD measurements (Dilation Rigs) in the period from setting to the end of the hardening phase some weeks after. These are the stress-inducing deformations in a hardening concrete structure subjected to restraint conditions.The main task was to carry out an RR program on testing of AD of one concrete at 20 °C isothermal conditions in Dilation Rigs. The concrete part materials were distributed to 10 laboratories (Canada, Denmark, France, Germany, Japan, The Netherlands, Norway, Sweden and USA), and in total 30 tests on AD were carried out. Some supporting tests were also performed, as well as a smaller RR on cement paste. The committee has worked out a test procedure recommendation which is reported separately and submitted acceptance as a RILEM method.

Taschenbuch. Zustand: Neu. Neuware - Having indicators to assess the effect of zootechnical, sanitary, economic or political intervention or the impact of environmental risks makes it possible to draw up strategies for improving domestic animal populations. This handbook is a compilation of the main concepts relating to the definition and calculation of demographic rates for largely non-intensive tropical animal farms. It is intended to be educational, and should help students, technicians, engineers, researchers and development staff to understand the definitions and formulas encountered in the literature more clearly and make them more self-sufficient in terms of analyses.

Taschenbuch. Zustand: Neu. Neuware - This book provides the most recent findings and knowledge in advanced diagnostics technology, covering a wide spectrum including brain activity analysis, breast and lung cancer detection, echocardiography, computer aided skeletal assessment to mitochondrial biology imaging at the cellular level. The authors explored magneto acoustic approaches and tissue elasticity imaging for the purpose of breast cancer detection. Perspectives in fetal echocardiography from an image processing angle are included. Diagnostic imaging in the field of mitochondrial diseases as well as the use of Computer-Aided System (CAD) are also discussed in the book. This book will be useful for students, lecturers or professional researchers in the field of biomedical sciences and image processing.

Taschenbuch. Zustand: Neu. Neuware - Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis. This is an exciting new direction in the field and the purpose of this book will be to highlight the current research directed at potential roles for the START family in diabetes, cancer and atherogenesis.This book also provides a personal and historical perspective of the discovery-to-publication journey that the authors had for their particular START domain family member. The goal will be to provide perspectives to graduate students, post-doctoral fellows and endocrinology fellows on the research discovery process.

Taschenbuch. Zustand: Neu. Neuware - The aim of this book is to offer a river-basin management plan which is directly implementable and consistent with the European Union -Water Framework Directive (EU WFD).The contributors, who are leading world experts in their respective fields, develop an integrated water resources management plan for the Asopos river basin in Greece which is economically efficient, socially equitable and environmentally sustainable. The program offers explicit technical and investment solutions, socioeconomic and legal instruments and recommendations for institutional restructuring. The introductory chapter describes the water situation in Greece and assesses the potential of timely implementation of the EU WFD. Special emphasis is given to the cost-recovery principle. Chapter 2 introduces the case study area highlighting the particular pressures and impacts as well as the environmental functions and values of Asopos River and Oropos Lagoon. Chapters 3 and 4 focus on the economic characterisation of Asopos River Basin in order to identify the economic sectors and social groups that will bear the cost and benefits of the implementation of the EU WFD. In particular, Chapter 3 presents the main water uses and pricing for water supply in the industrial and the agricultural sectors. Chapter 4 completes the baseline appraisal, presenting the details of water use by the residential and touristic sectors. The following chapters assess valuation and decision-making tools from a range of perspectives, including agricultural needs, valuing the impacts of industrial activity, the costs and benefits of environmental preservation and management. The water resources management plan is presented in Chapter 9; the concluding chapter offers recommendations on institutional changes and presents the lessons learned as resources applicable to other river basins in Greece and elsewhere. The book applies state-of-the art market and non-market valuation methods to estimate water demands in the residential, industrial, agricultural, tourism, environmental and health sectors and to balance these, over time and space, with water supply. Given the well-known challenge of managing natural resources in a way that maximizes and sustains social welfare, this book will provide an invaluable point of reference for applied researchers and policy makers working in water resources management.

Taschenbuch. Zustand: Neu. Neuware - This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

Taschenbuch. Zustand: Neu. Neuware - This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Taschenbuch. Zustand: Neu. Neuware - For many years, the authors have investigated the adaptive role of heat shock proteins (HSPs) in different animals, including the representatives of homothermic and poikilothermic organisms that inhabit regions with contrasting thermal conditions. This book will summarize the data accumulated in the course of these studies and describe the general molecular mechanisms underlying the adaptation of various organisms to aggressive environments. We also concentrate on different evolutionary trends characteristic for HSP systems in the course of adaptation to fluctuating environmental conditions. In addition, we describe the peculiarities in the regulatory regions of heat shock genes necessary for fine tuning of these systems providing the adaptation to adverse conditions. Special emphasis is given to the role of mobile elements in the evolution and functioning of various groups of HSP genes. The book combines the results of field studies and laboratory analysis of stress genes systems.

Taschenbuch. Zustand: Neu. Neuware - This book examines the textual, social, cultural, practical and institutional environments to which the expression 'teaching and learning contexts' refers. It reflects on the extent to which studying such environments helps us to better understand ancient or modern sources, and how notions of 'teaching' and 'learning' are to be understood.Tackling two problems: the first, is that of certain sources of scientific knowledge being studied without taking into account the various 'contexts' of transmission that gave this knowledge a long-lasting meaning. The second is that other sources are related to teaching and learning activities, but without being too precise and demonstrative about the existence and nature of this 'teaching context'. In other words, this book makes clear what is meant by 'context' and highlights the complexity of the practice hidden by the words 'teaching' and 'learning'. Divided into three parts, the book makes accessible teaching and learning situations, presents comparatist approaches, and emphasizes the notion of teaching as projects embedded in coherent treatises or productions.

Taschenbuch. Zustand: Neu. Neuware - Justice, conflict and wellbeing are large topics that occupy researchers from a variety of disciplines, as well as laypeople and policy makers. The three concepts are closely connected: conflict often (though not always) impairs wellbeing, whereas justice often (though not always) enhances it; perceived injustice is a common source of conflict, at multiple levels and calls for justice are a common response to conflict. In addition, each construct has subtypes, such as distributive and procedural justice, individual and group conflict and physical and psychological wellbeing. Although there are established traditions of research on the topics in multiple disciplines, there is little cross-fertilization across disciplines. This volume brings together researchers from social, clinical and educational psychology; law and political science. The unifying theme is how injustice and conflict pose threats to wellbeing, at the micro (individual) and macro (groups and societies) levels. Multi- and interdisciplinary research are at the vanguard of science in the twenty-first century and the present work applies multi and interdisciplinary perspectives to the important real-world topics of justice, conflict and wellbeing.

Taschenbuch. Zustand: Neu. Neuware - This book discusses recent developments and contemporary research in mathematics, statistics and their applications in computing. All contributing authors are eminent academicians, scientists, researchers and scholars in their respective fields, hailing from around the world. The conference has emerged as a powerful forum, offering researchers a venue to discuss, interact and collaborate and stimulating the advancement of mathematics and its applications in computer science. The book will allow aspiring researchers to update their knowledge of cryptography, algebra, frame theory, optimizations, stochastic processes, compressive sensing, functional analysis, complex variables, etc. Educating future consumers, users, producers, developers and researchers in mathematics and computing is a challenging task and essential to the development of modern society. Hence, mathematics and its applications in computer science are of vital importance to a broad range of communities, including mathematicians and computing professionals across different educational levels and disciplines.

Taschenbuch. Zustand: Neu. Neuware - This book is dedicated to applied computational intelligence and soft computing techniques with special reference to decision support in Cyber Physical Systems (CPS), where the physical as well as the communication segment of the networked entities interact with each other. The joint dynamics of such systems result in a complex combination of computers, software, networks and physical processes all combined to establish a process flow at system level.This volume provides the audience with an in-depth vision about how to ensure dependability, safety, security and efficiency in real time by making use of computational intelligence in various CPS applications ranging from the nano-world to large scale wide area systems of systems.Key application areas include healthcare, transportation, energy, process control and robotics where intelligent decision support has key significance in establishing dynamic, ever-changing and high confidence future technologies. A recommended text for graduate students and researchers working on the applications of computational intelligence methods in CPS.

Taschenbuch. Zustand: Neu. Neuware - The first OZCOTS conference in 1998 was inspired by papers contributed by Australians to the 5th International Conference on Teaching Statistics. In 2008, as part of the program of one of the first National Senior Teaching Fellowships, the 6 th OZCOTS was held in conjunction with the Australian Statistical Conference, with Fellowship keynotes and contributed papers, optional refereeing and proceedings. This venture was so successful that the 7 th and 8 th OZCOTS were similarly run, conjoined with Australian Statistical Conferences in 2010 and 2012. Authors of papers from these OZCOTS conferences were invited to develop chapters for refereeing and inclusion in this volume. There are sections on keynote topics, undergraduate curriculum and learning, professional development, postgraduate learning, and papers from OZCOTS 2012. Because OZCOTS aim to unite statisticians and statistics educators, the approaches this volume takes are immediately relevant to all who have a vested interest in good teaching practices. Globally, statistics as a discipline, statistical pedagogy and statistics in academia and industry are all critically important to the modern information society. This volume addresses these roles within the wider society as well as questions that are specific to the discipline itself. Other chapters share research on learning and teaching statistics in interdisciplinary work and student preparation for futures in academia, government and industry.

Taschenbuch. Zustand: Neu. Neuware - The book departs from the approach of related titles by focusing on describing and reflecting upon the notion of seamless learning with regard to salient characteristics of learner mobility and bridging of learning experiences across learning spaces. It is the first such work that is solely dedicated to research on and the practice of seamless learning, uniquely combining interpretations, visions, and past research on and practices in seamless learning from diversified perspectives. The book also strikes a good balance between theoretical and practical perspectivess, going beyond a collection of reports on specific research projects. Instead of thick descriptions of research processes and findings, readers will find significant insights and food for thought intended to inspire further advances in the research on and practice of seamless learning.

Taschenbuch. Zustand: Neu. Neuware - Optimization in Science and Engineering is dedicated in honor of the 60th birthday of Distinguished Professor Panos M. Pardalos. Pardalos's past and ongoing work has made a significant impact on several theoretical and applied areas in modern optimization. As tribute to the diversity of Dr. Pardalos's work in Optimization, this book comprises a collection of contributions from experts in various fields of this rich and diverse area of science.Topics highlight recent developments and include:Deterministic global optimizationVariational inequalities and equilibrium problemsApproximation and complexity in numerical optimizationNon-smooth optimization Statistical models and data miningApplications of optimization in medicine, energy systems, and complex network analysisThis volume will be of great interest to graduate students, researchers, and practitioners, in the fields of optimization and engineering.

Taschenbuch. Zustand: Neu. Neuware - Achieving operational excellence is a challenge for the pharmaceutical industry, with many companies setting successful examples time and again. This book presents such leading practices for managing operational excellence throughout the pharmaceutical industry. Based on the St.Gallen OPEX Model the authors describe the current status of OPEX and the future challenges that have to be dealt with. The ample theoretical background is complemented hand-in-hand by case studies contributed by authors from leading pharmaceutical companies.

Taschenbuch. Zustand: Neu. Neuware - Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. In the past several years, there have been significant developments in understanding of HNC. It is now recognized that although alcohol and tobacco use has represented the likely predominant cause of SCCHN, the incidence of a second class of SCCHN related to oncogenic human papillomavirus (HPV) infection is increasing, with a four-fold increase in the past 2 decades, and now thought to represent up to 30% of cases. The first effective target for SCCHN, the EGFR-targeting antibody cetuximab, was approved as recently as in 2006; since then, a growing body of research has identified additional signaling pathways as important in disease pathogenesis, and in resistance to treatment. Proteins such as c-Met, Src, and HER2 are emerging as new therapeutic targets, with a considerable ferment in the clinical trial community. As a capstone of research progress, 2011 marked the first reports of high throughput sequencing of SCCHN tumors, with these efforts identifying unexpected players such as Notch as frequent subject of mutation, spawning new hypotheses for future research. This book will be of interest to researchers who are interested in better understanding the biology of head and neck cancers, with the goals of better designing therapies, identifying risk factors, or investigating the molecular basis of the disease.

Taschenbuch. Zustand: Neu. Neuware - miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-beta and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

Taschenbuch. Zustand: Neu. Neuware - There is a tremendous interest among researchers for the development of virtual, augmented reality and games technologies due to their widespread applications in medicine and healthcare. To date the major applications of these technologies include medical simulation, telemedicine, medical and healthcare training, pain control, visualisation aid for surgery, rehabilitation in cases such as stroke, phobia and trauma therapies. Many recent studies have identified the benefits of using Virtual Reality, Augmented Reality or serious games in a variety of medical applications.This research volume on Virtual, Augmented Reality and Serious Games for Healthcare 1 offers an insightful introduction to the theories, development and applications of virtual, augmented reality and digital games technologies in medical and clinical settings and healthcare in general. It is divided into six sections: section one presents a selection of applications in medical education and healthcare management; Section two relates to the nursing training, health literacy and healthy behaviour; Section three presents the applications of Virtual Reality in neuropsychology; Section four includes a number of applications in motor rehabilitation; Section five aimed at therapeutic games for various diseases; and the final section presents the applications of Virtual Reality in healing and restoration.This book is directed to the healthcare professionals, scientists, researchers, professors and the students who wish to explore the applications of virtual, augmented reality and serious games in healthcare further.

Taschenbuch. Zustand: Neu. Neuware 552 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and 'reverse' Warburg effect--these topics and more are discussed in this volume.

Taschenbuch. Zustand: Neu. Neuware - Abiotic stress drastically limits agricultural crop productivity worldwide. Climate change threatens the sustainable agriculture with its rapid and unpredictable effects, making it difficult for agriculturists and farmers to respond to the challenges cropping up from environmental stresses. In light of population growth and climate changes, investment in agriculture is the only way to avert wide scale food shortages. This challenge comes at a time when plant sciences are witnessing remarkable progress in understanding the fundamental processes of plant growth and development. Plant researchers have identified genes controlling different aspects of plant growth and development, but many challenges still exist in creating an apt infrastructure, access to bioinformatics and good crop results. Improvement of Crops in the Era of Climatic Changes, Volume 2 focuses on many existing opportunities that can be applied methodically through conventional breeding, without touching upon the latest discoveries such as the power of genomics to applied breeding in plant biology.Written by a diverse faction of internationally famed scholars, this volume adds new horizons in the field of crop improvement, genetic engineering and abiotic stress tolerance. Comprehensive and lavishly illustrated, Improvement of Crops in the Era of Climatic Changes, Volume 2 is a state-of-the-art guide to recent developments vis-à-vis various aspects of plant responses in molecular and biochemical ways to create strong yields and overall crop improvement.

Taschenbuch. Zustand: Neu. Neuware - This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

Taschenbuch. Zustand: Neu. Neuware - The rapidly developing field of nanomaterials has expanded in many commercial areas. More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, including research into stem cells. Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues. While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function. In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer and an increasing number of new applications. This book investigates these areas and also includes new methods for assessment in cell biology and medicine.

Taschenbuch. Zustand: Neu. Neuware - Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This bookwill providea comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective.

Taschenbuch. Zustand: Neu. Neuware - This book of proceedings collects fifty-one papers presented at the inaugural Colloquium of Administrative Science and Technology (CoAST 2013) event, held at Kuching, Sarawak, Malaysia. It has been reviewed by 750 experts world-wide and covers three main areas - Administrative Science and Technology, Management, and Arts and Humanities. The papers in this volume reflect:- the importance of the social sciences in academia and in the nations' social-economic growth;- the multi-disciplinary and trans-disciplinary nature of academia that transcends the broad areas of the social sciences;- the increasing trend towards fundamental studies in the social sciences, management, and the arts and the humanities, which have been characterized under the overarching theme of administrative science and technology;- the growing demand for research outcomes affecting the public and private sectors' service processes. The other overlapping niche areas affecting the civil service scope will ensure more interest in and readability of the findings showcased in this proceedings book;- the popular and contemporary measurement techniques and methodologies employed within the scopes of the social sciences and humanities;- the noticeably changing trends in administrative science and technology, which will greatly impact the governments of the world, allowing the development of a better understanding of governmental processes and their impact on key performance and e-service deliveries. The reporting on technology-based services will improve the public sector's agility;- a knowledge-sharing agenda for other developing and less developed nations to emulate;- some of the major generic developments that have taken place in these thematic areas of CoAST 2013.

Taschenbuch. Zustand: Neu. Neuware - A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

Taschenbuch. Zustand: Neu. Neuware - DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids.The areas covered in this volume include: Background and general biology of circulating nucleic acids Methodology Applications of circulating nucleic acids Quality Assurance Ethics.

Taschenbuch. Zustand: Neu. Neuware - Business Process Management (BPM) has become one of the most widely used approaches for the design of modern organizational and information systems. The conscious treatment of business processes as significant corporate assets has facilitated substantial improvements in organizational performance but is also used to ensure the conformance of corporate activities. This Handbook presents in two volumes the contemporary body of knowledge as articulated by the world's leading BPM thought leaders. This second volume focuses on the managerial and organizational challenges of BPM such as strategic and cultural alignment, governance and the education of BPM stakeholders. As such, this book provides concepts and methodologies for the integration of BPM. Each chapter has been contributed by leading international experts. Selected case studies complement their views and lead to a summary of BPM expertise that is unique in its coverage of the most critical success factors of BPM.The second edition of this handbook has been significantly revised and extended. Each chapter has been updated to reflect the most current developments. This includes in particular new technologies such as in-memory data and process management, social media and networks. A further focus of this revised and extended edition is on the actual deployment of the proposed theoretical concepts. This volume includes a number of entire new chapters from some of the world's leading experts in the domain of BPM.