Springer sep 1984 (5 Ergebnisse)

Buch. Zustand: Neu. Neuware - Receptor specific antibodies are excellent probes for a wide range of biological investigations on receptor structure and function. The hybridoma technology (Kohler and Milstein, 1975) has inevitably had a major impact on this field with most of the better known receptors now identified with monoclonal antibodies. This volume of the Receptors and Recognition series provides reviews of recent developments in this field and emphasizes in particular the new opportunities afforded by the judicious application of monoclonal reagents. It is assumed that most readers will be familiar with the now fairly routine methods of cell fusion, hybridoma cloning and selection for producing monoclonal antibodies and so few details of the basic technical procedures are described. Several good reviews on this topic are however available (see Galfre and Milstein, 1981; Goding, 1980; Yelton and Scharf, 1981; McMichael and Fabre, 1982). By no means all vertebrate receptor species are discussed here; omissions include antibodies to low density lipoprotein receptors (Beisiegel et al. , 1981; Kita et al. , 1981), prolactin and growth hormone receptors (Friesen etal. , 1982; Simpson et al. , 1983) and the hepatocyte asialoglycoprotein receptor (Schwartz et al. , 1981; Harford et al. , 1982). Nevertheless the coverage is comprehensive and critical and the individual chapters provided illustrate vividly the rapid progress being made.…

Buch. Zustand: Neu. Neuware - Patients with a variety of tumors present to the physician because of clinical manifestations of hormones secreted in excess. This phenomenon attracted the investigative interest of such pioneers as Harvey Cushing who recognized that pituitary tumors may cause acromegaly and Charles Mayo who associated hyper tension with adrenal medullary neoplasms. Current int~rest in endocrine-related tumors has intensified because of the explosive development of newer methodol ogy for their study. Specific measurements of secretory products, hybridization assays to identify products of genomic translation and quantitative assessment of tissue hormone receptors have provided means of characterizing and precisely following patients with endocrine-related tumors. Treatments based upon these advances are rapidly proliferating. The current volume attempts to synthesize much of this recent information with the goal of providing a sound basis for making clinical judgements regarding diagnosis and management. Tumors of endocrine glandular tissues commonly confront practicing physi cians with difficult management problems. Several unique features of these tumors necessitate collaboration among various specialty disciplines in order to resolve these problems and to provide a high level of clinical care. For example, endocrine neoplasms secrete active hormones or hormone precursors which produce clinical manifestations most familiar to endocrinologists. Certain thera pies such as radioactive iodine for thyroid cancer take advantage of the hormone responsiveness of these tumors to facilitate treatment. These aspects require individuals trained in endocrinology to implement complex diagnostic and thera peutic maneuvers.…

Buch. Zustand: Neu. Neuware.

Buch. Zustand: Neu. Neuware - Lazar Mayants is a recent Russian emigre noted for his work in theoretical physics. He was previously a professor at several universities of the Soviet Union and a distinguished member of the Academy of Sciences of the U.S.S.R, where he worked for about 30 years. In this book he presents a unique, extremely detailed, and embracive version of a subject that has suffered for a long time from numerous internal imperfections. His approach is new and original, the material covered features not only the foundations of the science of probability but also most of its applications, including statistical and quantum mechanics. The key methodolOgical principle underlying the book is of extraordinary significance and deserves special attention. The treatment excels in thoroughness of presentation, in its fulness of mathe matical detail and the abundance of physical examples. The book is intended for a wide range of people interested in probability and its connection with modern science. It is written as a text for advanced students, and I predict that a reader who masters all its contents will become an expert in the subject of both prob ability and its physical implications, while enjoying its understanding and use. HENRY MARGENAU Veritas nihil veretur nisi abscondi (truth 'What tremendously easy riddles you ask!' Humpty Dumpty growled out. fears nothing except being hidden). Latin proverb Lewis Carroll, Through the Looking Glass, Chap. 6. Preface The history of producing this book is rather complicated and not quite usual.…

Buch. Zustand: Neu. Neuware.